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Elucidation of the relationship between brain function and occlusion- mastication-nutrition, and development of prosthodontic health management model

Research Project

Project/Area Number 18H02993
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionThe University of Tokushima

Principal Investigator

ICHIKAWA Tetsuo  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (90193432)

Co-Investigator(Kenkyū-buntansha) 後藤 崇晴  徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (00581381)
誉田 栄一  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (30192321)
白山 靖彦  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (40434542)
水頭 英樹  徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (70732915)
伊藤 照明  徳島大学, 大学院社会産業理工学研究部(理工学域), 准教授 (90284306)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords脳機能 / 口腔機能 / 前頭前野 / 近赤外分光分析法 / 栄養 / 口腔感覚 / 咀嚼 / 補綴健康管理モデル / 地域包括ケア / 高次機能 / 感覚 / 感覚刺激 / 咬合 / 高次脳機能
Outline of Final Research Achievements

Regarding the relationship between maintenance of tooth contact/occlusion and cognitive decline showed that; 1) little evidence of nutritional improvement pathway, the importance of social environment improvement. 2) The simple task of oral movements did not increase cerebral blood flows in the prefrontal cortex (BFs-PC), whereas the complex sensory task did. 3) Taste and smell stimulation increased the BFs-PC, suggesting the influence of taste and smell stimulation during eating. 4) The field survey showed that the relationship between poor oral function and psychosomatic frailty, the importance of addressing psychosomatic issues to cognitive decline, the influence of dietary independence on food intake diversity and higher life functions, and higher MMSE values in non-solitary eaters than in solitary eaters. Based on the above, we proposed a prosthodontic health management model that provides an environment with appropriate dentition, nutrition, and sensory stimulation.

Academic Significance and Societal Importance of the Research Achievements

歯や咬合の保存が認知機能に影響を与えていることは多くの臨床研究から示されているが、その因果関係を生命科学的に証明しようとする試みは少なく、本研究はそのことを脳科学的かつフィールド研究から解明しようとするものであり、学術的意義は高い。その結果は、感覚系を介する脳への刺激,あるいは食事を介する社会的環境による影響が示され、それに基づく補綴歯科健康管理モデルの構築は、今後のポピュレーションアプローチとして社会的意義も高い。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (8 results)

All 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Relationship between declines of physical performances and consciousness in elderly: Occlusal force, grip strength, and walking speed2019

    • Author(s)
      後藤 崇晴, 市川 哲雄
    • Journal Title

      The Journal of the Japanese Academy of Occulusion and Health

      Volume: 25 Issue: 2 Pages: 39-43

    • DOI

      10.34420/jjaoh.25.2_39

    • NAID

      130007805900

    • ISSN
      1344-2007, 2435-2853
    • Year and Date
      2019-10-20
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The application and usefulness of virtual reality aimed at encouraging an understanding of and reducing and eliminating prejudice towards dementia patients among local residents2019

    • Author(s)
      白山 靖彦, 湯浅 雅志, 樫森 節子, 北村 美渚, 後藤 崇晴, 寺西 彩, 柳沢 志津子, 竹内 祐子, 市川 哲雄, 臼谷 佐和子
    • Journal Title

      Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

      Volume: 56 Issue: 2 Pages: 156-163

    • DOI

      10.3143/geriatrics.56.156

    • NAID

      130007650187

    • ISSN
      0300-9173
    • Year and Date
      2019-04-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prefrontal cortex activity induced by periodontal afferent inputs downregulates occlusal force2019

    • Author(s)
      Kishimoto T, Goto T, Ichikawa T.
    • Journal Title

      Exp Brain Res

      Volume: 237 Issue: 11 Pages: 2767-2774

    • DOI

      10.1007/s00221-019-05630-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] タッピング運動が前頭前野の脳血流量に与える影響2019

    • Author(s)
      岸本 卓大, 後藤 崇晴, 市川 哲雄
    • Organizer
      日本咀嚼学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 地域の看取りと口腔健康管理 限界集落で口腔健康管理はされているか2019

    • Author(s)
      市川 哲雄, 後藤 崇晴, 松田 岳, 藤本 けい子, 永尾 寛, 白山 靖彦
    • Organizer
      日本老年学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 咬合力の維持タスクと前頭前野の脳血流量:開口量と前歯,臼歯の違いによる影響2018

    • Author(s)
      岸本卓大,後藤崇晴,市川哲雄
    • Organizer
      第28回日本全身咬合学会学術大会 2018年11月25日 鶴見
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neuroscientific evaluation of periodontal tactile with/without sensory integration task: comparison between incisor and molar teeth2018

    • Author(s)
      Takahiro Kishimoto, Takaharu Goto, Tetsuo Ichikawa
    • Organizer
      11th Biennial Congress of Asian Academy of Prosthodontics, Kuala Lumpur, Malaysia, September 21-23, 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] マグニチュード推定法を用いた口腔内の感受性評価と脳血流量との関連 平成30年度2018

    • Author(s)
      岸本卓大,後藤崇晴,市川哲雄
    • Organizer
      公益社団法人日本補綴歯科学会 第127回学術大会 2018.6.16,岡山
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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