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Molecular targeted therapy for MRONJ

Research Project

Project/Area Number 18H02994
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionNagasaki University

Principal Investigator

KUROSHIMA Shinichiro  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (40443915)

Co-Investigator(Kenkyū-buntansha) 中野 貴由  大阪大学, 工学研究科, 教授 (30243182)
住田 吉慶  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (50456654)
柴田 恭明  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (80253673)
大塚 正人  東海大学, 医学部, 教授 (90372945)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords薬剤関連顎骨壊死 / ビスホスホネート製剤 / 抗RANKL抗体製剤 / 血管新生抑制薬 / マクロファージ / 薬剤関連顎骨壊死(MRONJ) / デノスマブ / BRONJ / DRONJ / 細胞療法 / 病因関連分子 / 治癒関連分子 / リンパ管 / 病因 / 分子標的治療 / ビスフォスフォネート製剤 / ロモソズマブ / 細胞治療 / 分子標的治療法 / 創傷治癒 / 動物モデル / 免疫病理 / 幹細胞 / 細胞移植
Outline of Final Research Achievements

Medication-related osteonecrosis of the jaw (MRONJ), which is scarce and potentially severe adverse effects of anti-resorptive drugs and/or angiogenesis inhibitor, significantly worsens quality of life. The aim was to investigated the effects of antiresorptive drug and angiogenesis inhibitors on soft and hard tissue healing with creating several rodent models of MRONJ-like lesions in order to clarify exact mechanisms and develop new treatment/prevention strategies for MRONJ. We found that similar and different histopathology and immunopathology between different medications by creating several types of rodent MRONJ-like lesions. Moreover, we identified that macrophage distribution and opalization shifting were corelated with the pathophysiology. Our findings may contribute to understanding of the pathophysiology of MRONJ and development of treatment and prevention strategies for MRONJ.

Academic Significance and Societal Importance of the Research Achievements

この研究では,現在でも原因が不明で確定的な治療法や予防法がない薬剤関連顎骨壊死に関する基礎的研究を行った.その結果,複数の薬剤関連顎骨壊死モデルマウスを作製・開発し,最終的にはマクロファージが薬剤関連顎骨壊死に深く関与していることを見出したが,この新しい知見が薬剤関連顎骨壊死の原因を解く鍵である可能性が高く,学術的意義があるといえる.また,科学的に薬剤関連顎骨壊死に対する詳細な解析を行ったことで,治療法や予防法開発の基盤を構築できたことに社会的意義があるといえる.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (76 results)

All 2022 2021 2020 2019 2018

All Journal Article (19 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 19 results,  Open Access: 11 results) Presentation (57 results) (of which Int'l Joint Research: 17 results,  Invited: 9 results)

  • [Journal Article] Zoledronic acid deteriorates soft and hard healing of murine tooth extraction sockets in a dose-dependent manner2022

    • Author(s)
      Kozutsumi R, Kuroshima S, Kaneko H, Sasaki M, Ishisaki A, Sawase T
    • Journal Title

      Calcif. Tissue Int.

      Volume: 110 Issue: 1 Pages: 104-116

    • DOI

      10.1007/s00223-021-00890-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alendronate/dexamethasone combination therapy worsens soft and hard tissue wound healing around implants in rat maxillae2021

    • Author(s)
      Inoue M, Matsumoto C, Nakajima K, Kuroshima S, Sawase T
    • Journal Title

      Bone

      Volume: 148 Pages: 115942-115942

    • DOI

      10.1016/j.bone.2021.115942

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis of fresh extraction wounds prior to onset of bisphosphonate-related osteonecrosis of the jaw-like lesions in mice: A preliminary animal study2021

    • Author(s)
      Kuroshima S, Nakajima K, Sasaki M, Hayano H, Inoue M, Kozutsumi R, Sawase T
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 65 Issue: 4 Pages: 546-553

    • DOI

      10.2186/jpr.JPR_D_20_00027

    • NAID

      130008104554

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical considerations for medication-related osteonecrosis of the jaw: A comprehensive literature review2021

    • Author(s)
      Kawahara M, Kuroshima S, Sawase T
    • Journal Title

      Int J Implant Dent.

      Volume: - Issue: 1 Pages: 47-47

    • DOI

      10.1186/s40729-021-00323-0

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct immunopathology in the early stages between different antiresorptive-related osteonecrosis of the jaw-like lesions in mice.2020

    • Author(s)
      Hayano H, Kuroshima S, Sasaki M, Tamki S, Inoue M, Ishisaki A, Sawase T
    • Journal Title

      Bone

      Volume: - Pages: 115308-115308

    • DOI

      10.1016/j.bone.2020.115308

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase 1 clinical study of cell therapy with effective-mononuclear cells (E-MNC) for radiogenic xerostomia (first-in-human study) (FIH study on E-MNC therapy for radiogenic xerostomia)2020

    • Author(s)
      Sumita Y, Iwamoto N, Seki M, Yoshida T, Honma R, Iwatake M, Ohba S, Takashi I, Hotokezaka Y, Harada H, Kuroshima S, Nagai K, Asahara T, Atsushi Kawakam I, Asahina I
    • Journal Title

      Medicine (Baltimore)

      Volume: 99 Issue: 26 Pages: e20788-e20788

    • DOI

      10.1097/md.0000000000020788

    • NAID

      120006988135

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice2020

    • Author(s)
      Tamaki Saki、Kuroshima Shinichiro、Hayano Hiroki、Nakajima Kazunori、Kakehashi Hiroe、Ishisaki Akira、Sawase Takashi
    • Journal Title

      Bone

      Volume: 141 Pages: 115560-115560

    • DOI

      10.1016/j.bone.2020.115560

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A stable protocol for the fabrication of transplantable human oral mucosal epithelial cell sheets for clinical application.2020

    • Author(s)
      Kasai Y, Takagi R, Kobayashi S, Owaki T, Yamaguchi N, Fukuda H, Sakai Y, Sumita Y, Kanai N, Isomoto H, Kanetaka K, Ohki T, Asahina I, Nagai K, Nakao K, Takeda N, Okano T, Eguchi S, Yamato M.
    • Journal Title

      Regen Ther.

      Volume: 14 Pages: 87-94

    • DOI

      10.1016/j.reth.2019.11.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs2019

    • Author(s)
      KHADIZA Naznin、HASEGAWA Tomoka、NAGAI Tomoya、YAMAMOTO Tomomaya、MIYAMOTO- TAKASAKI Yukina、HONGO Hiromi、ABE Miki、HARAGUCHI Mai、YAMAMOTO Tsuneyuki、YIMIN、QIU Zixuan、SASAKI Muneteru、KUROSHIMA Shinichiro、OHSHIMA Hayato、FREITAS Paulo Henrique Luiz de、LI Minqi、YAWAKA Yasutaka、AMIZUKA Norio
    • Journal Title

      Biomedical Research

      Volume: 40 Issue: 4 Pages: 133-143

    • DOI

      10.2220/biomedres.40.133

    • NAID

      130007689882

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2019-08-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Medication-related Osteonecrosis of the Jaw: A Literature Review.2019

    • Author(s)
      Kuroshima S, Sasaki M, Sawase T
    • Journal Title

      J Oral Biosci.

      Volume: 62 Issue: 2 Pages: 99-104

    • DOI

      10.1016/j.job.2019.03.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic administration of quality- and quantity-controlled PBMNCs reduces bisphosphonate-related osteonecrosis of the jaw-like lesions in mice2019

    • Author(s)
      Kuroshima S, Nakajima K, Sasaki M, Takashi I, Y Sumita, Asahara T, Asahina I, Sawase T
    • Journal Title

      Stem Cell Res Ther.

      Volume: 10 Issue: 1 Pages: 209-209

    • DOI

      10.1186/s13287-019-1308-8

    • NAID

      120006988442

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Medication-related Osteonecrosis of the Jaw-like Lesions in Rodents: A Comprehensive Systematic Review and Meta-Analysis2019

    • Author(s)
      Kuroshima S, Sasaki M, Murata H, Sawase T.
    • Journal Title

      Gerodontology

      Volume: 36 Issue: 4 Pages: 313-324

    • DOI

      10.1111/ger.12416

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histochemical examination on principal collagen fibers in periodontal ligaments of ascorbic acid-deficient ODS-od/od rats.2019

    • Author(s)
      Hasegawa T., Miyamoto Y., Abe M., Qiu Z., Yamamoto T., Yimin, Yoshida T., Yoshino H., Hongo H., Yokoyama A., Sasaki M., Kuroshima S., Hara K., Kobayashi M., Akiyama Y., Maeda T., Freitas PHL., Li M., Amizuka N.
    • Journal Title

      Microscopy.

      Volume: 68 Issue: 5 Pages: 349-358

    • DOI

      10.1093/jmicro/dfz021

    • NAID

      120006891507

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.2019

    • Author(s)
      I T, Sumita Y, Yoshida T, Honma R, Iwatake M, Raudales JLM, Shizuno T, Kuroshima S, Masuda H, Seki M, Tran SD, Asahara T, Asahina I.
    • Journal Title

      Stem Cell Res Ther.

      Volume: 10 Issue: 1 Pages: 304-304

    • DOI

      10.1186/s13287-019-1414-7

    • NAID

      120006988389

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound2019

    • Author(s)
      Ishimoto Takuya、Suetoshi Ryoichi、Cretin Dorian、Hagihara Koji、Hashimoto Jun、Kobayashi Akio、Nakano Takayoshi
    • Journal Title

      Bone

      Volume: 127 Pages: 82-90

    • DOI

      10.1016/j.bone.2019.05.034

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteoporosis changes collagen/apatite orientation and Young’s modulus in vertebral cortical bone of rat2019

    • Author(s)
      Ryosuke Ozasa, Takuya Ishimoto, Sayaka Miyabe, Jun Hashimoto, Makoto Hirao, Hideki Yoshikawa, Takayoshi Nakano
    • Journal Title

      Calcified Tissue International

      Volume: 104 Issue: 4 Pages: 449-460

    • DOI

      10.1007/s00223-018-0508-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alveolar bone preservation by a hydroxyapatite/collagen composite material after tooth extraction.2019

    • Author(s)
      Ohba S, Sumita Y, Nakatani Y, Noda S, Asahina I.
    • Journal Title

      Clin Oral Investig

      Volume: 23 Issue: 5 Pages: 2413-2419

    • DOI

      10.1007/s00784-018-2705-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of bisphosphonate-related osteonecrosis of the jaw-like lesions is increased in a chemotherapeutic dose-dependent manner in mice2018

    • Author(s)
      Kuroshima S, Sasaki M, Nakajima K, Tamaki S, Hayano H, Sawase T
    • Journal Title

      Bone

      Volume: 112 Pages: 177-186

    • DOI

      10.1016/j.bone.2018.05.001

    • NAID

      120006988373

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow concentrate promotes bone regeneration with a suboptimal-dose of rhBMP-22018

    • Author(s)
      Egashira Kazuhiro、Sumita Yoshinori、Zhong Weijian、I Takashi、Ohba Seigo、Nagai Kazuhiro、Asahina Izumi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: e0191099-e0191099

    • DOI

      10.1371/journal.pone.0191099

    • NAID

      120006988082

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ビスホスホネート製剤の投与濃度が抜歯窩治癒に与える影響2021

    • Author(s)
      黒嶋伸一郎
    • Organizer
      一般社団法人日本顎顔面補綴学会第38回総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 間葉系幹細胞の研究から考える生物科学としての補綴歯科治療.2021

    • Author(s)
      黒嶋伸一郎,熱田 生,秋山謙太郎,加来 賢
    • Organizer
      公益社団法人日本補綴歯科学会 第130回記念学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ビスホスホネート製剤とステロイド製剤がインプラント周囲硬軟組織に与える影響2021

    • Author(s)
      黒嶋伸一郎,佐々木宗輝
    • Organizer
      一般社団法人日本老年歯科医学会第32回学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高濃度BP製剤が抜歯窩硬軟組織治癒に与える影響2021

    • Author(s)
      小堤涼平, 黒嶋伸一郎, 佐々木宗輝
    • Organizer
      一般社団法人日本老年歯科医学会第32回学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ビスホスホネート製剤の投与は濃度依存性に抜歯部の硬組織治癒遅延を惹起する2021

    • Author(s)
      小堤涼平, 黒嶋伸一郎, 佐々木宗輝, 金子 遥, 澤瀬 隆
    • Organizer
      公益社団法人日本補綴歯科学会 第130回記念学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 「病理組織学的・免疫病理学的観点からとらえた薬剤関連顎骨壊死の病因・病態解明と治療法開発研究」.2021

    • Author(s)
      黒嶋伸一郎
    • Organizer
      第41回日本骨形態計測学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] アレンドロネートとデキサメサゾンがインプラント周囲硬軟組織治癒に与える影響2021

    • Author(s)
      黒嶋 伸一郎,井上真愛弥,松本知生,中島和慶,澤瀬 隆
    • Organizer
      第41回日本骨形態計測学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ゾレドロネートの投与は濃度依存性に抜歯窩治癒遅延を惹起する.2021

    • Author(s)
      小堤涼平, 黒嶋伸一郎, 佐々木宗輝, 金子 遥, 澤瀬 隆
    • Organizer
      第41回日本骨形態計測学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effects of alendronate/dexamethasone combination therapy on wound healing around implants in rat maxillae2021

    • Author(s)
      Inoue M, Kuroshima S, Matsumoto C, Nakajima K, Sawase T
    • Organizer
      99th General Session and Exhibition of the IADR
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of high-dose zoledronic acid on tooth extraction socket healing in mice2021

    • Author(s)
      Kozutsumi R, Kuroshima S, Kaneko H, Sasaki M, Sawase T
    • Organizer
      99th General Session and Exhibition of the IADR
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medication-related Osteonecrosis of the Jaw: Clinical Consideration AND pathophysiology, pathology and treatment strategy2021

    • Author(s)
      Kuroshima S
    • Organizer
      The 12th Biennial congress of Asian Academy of Prosthodontics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 歯科系骨代謝研究に見られる最近の進展.薬剤関連顎骨壊死の現状とその課題を基礎と臨床的観点から紐解く2021

    • Author(s)
      黒嶋伸一郎
    • Organizer
      第39回日本骨代謝学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ビスホスホネート製剤関連顎骨壊死ステージ0様病変悪化モデルの作製とTRAP陽性細胞の組織内動態解析2021

    • Author(s)
      小堤 涼平,黒嶋伸一郎,佐々木宗輝,金子 遥,澤瀬 隆
    • Organizer
      第39回日本骨代謝学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 臨床を鑑みたビスフォスフォネート製剤関連顎骨壊死ステージ0モデルマウスの作製と病因・病態解明研究2021

    • Author(s)
      小堤 涼平,黒嶋伸一郎,佐々木宗輝,金子 遥,澤瀬 隆
    • Organizer
      第51回公益社団法人日本口腔インプラント学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 血管新生阻害薬とビスフォスフォネート製剤が抜歯窩治癒に与える影響の検索2021

    • Author(s)
      金子 遥,黒嶋伸一郎,小堤涼平,澤瀬 隆
    • Organizer
      第39回日本口腔インプラント学会九州支部学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Administration of zoledronic acid worsens osseous wound healing of tooth extraction sockets in a bisphosphonate dose dependent manner in mice2021

    • Author(s)
      Kozutsumi R, Kuroshima S, Kaneko H, Sawase T.
    • Organizer
      The 7th Biennial Joint Congress of JPS-CPS-KAP
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高頻度発現型BRONJ様病変の組織・免疫病理学所見と早期遺伝子プロファイル分析2020

    • Author(s)
      黒嶋伸一郎,佐々木宗輝,中島和慶,早野博紀,井上真愛弥,澤瀬 隆
    • Organizer
      公益社団法人日本補綴歯科学会 第129回学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] インプラント周囲に惹起される高頻度発現型BRONJ様病変モデルの作成と病態解析2020

    • Author(s)
      井上真愛弥,松本知生,黒嶋伸一郎,右藤友督,内田悠介,澤瀬 隆
    • Organizer
      公益社団法人日本補綴歯科学会 第129回学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] インプラント周囲に惹起されるビスホスホネート製剤関連顎骨壊死モデルの作成と病態解明研究2020

    • Author(s)
      井上真愛弥,松本知生,黒嶋伸一郎,中島和慶,澤瀬 隆
    • Organizer
      第50回公益社団法人口腔インプラント学会記念学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 骨吸収齲抑制薬関連顎骨壊死の病理学と組織学2020

    • Author(s)
      黒嶋伸一郎,佐々木宗輝,中島和慶,澤瀬 隆
    • Organizer
      第62回歯科基礎歯学会学術大会.日本骨形態計測学会合同シンポジウム【石灰化組織評価の実践とネットワーキング】
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] アレンドロネートとデキサメタゾンがデンタルインプラント周囲硬軟組織に与える影響2020

    • Author(s)
      井上真愛弥,松本知生,黒嶋伸一郎,右藤友督,内田悠介,稲葉菜緒,澤瀬 隆
    • Organizer
      第38回日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高頻度発現型BRONJマウスモデルを用いた早期における遺伝子パターン解析2020

    • Author(s)
      黒嶋伸一郎,早野博紀,佐々木宗輝,中島和慶,澤瀬 隆
    • Organizer
      第38回日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Relationship between gene profiles and histopathology/immunopathology in high-prevalence BRONJ-like lesions in mice2020

    • Author(s)
      Kuroshima S, Sasaki M, Hayano H, Kozutsumi R, Inoue M, Sawase T
    • Organizer
      30th Annual Congress of the European College of Gerodontology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Histopathology/immunopathology in high-prevalence bisphosphonate-related osteonecrosis of the jaw around implants in rat maxillae2020

    • Author(s)
      Inoue M, Matsumoto C, Nakajima K, Hayano H, Kozutsumi R, Kuroshima S, Sawase T
    • Organizer
      30th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting Virtual
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene expression profiling and histopathology/immunopathology in high-prevalence bisphosphonate-related osteonecrosis of the jaw in mice2020

    • Author(s)
      Kuroshima S, Sasaki M, Nakajima K, Hayano H, Inoue M, Kozutsumi R, Sawase T
    • Organizer
      30th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting Virtual
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗RANKL抗体とビスホスホネート製剤誘発性顎骨壊死様病変は免疫病理所見が異なる2020

    • Author(s)
      黒嶋伸一郎,佐々木宗輝
    • Organizer
      一般社団法人日本老年歯科医学会第31回学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] BRONJを緩解するSVF細胞とQQMNC細胞移植は抜歯窩治癒に異なった影響を与える2019

    • Author(s)
      黒嶋伸一郎,佐々木宗輝,玉城沙貴,早野博紀,澤瀬 隆
    • Organizer
      公益社団法人日本補綴歯科学会 第128回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗RANKL抗体製剤誘発性顎骨壊死は薬剤の休薬によりその病態を治癒させる2019

    • Author(s)
      玉城沙貴,黒嶋伸一郎,早野博紀,井上真愛弥,澤瀬 隆
    • Organizer
      公益社団法人日本補綴歯科学会 第128回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of phosphorus on osteocyte function and aging2019

    • Author(s)
      Sasaki M, Kuroshima S, Sawase T
    • Organizer
      Secretariat of the 7th Seoul Symposium on Bone Health (SSBH 2019) & the 31th Annual Meeting of the Korean Society for Bone and Mineral Research(KSBMR)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of antiresorptives/chemotherapeutic combination therapy on tooth extraction socket healing2019

    • Author(s)
      Hayano H, Kuroshima S, Tamaki S, Inoue M, Sawase T
    • Organizer
      97th General session & Exhibition of the IADR
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transplantation of SVF cells and QQ-MNCs reduces BRONJ-like lesions through distinct healing processes in mice2019

    • Author(s)
      Kuroshima S, Sasaki M, Hayano H, Tamaki S, Inoue M, Sawase T
    • Organizer
      97th General session & Exhibition of the IADR
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗RANKL抗体製剤誘発性高頻度発現型マウス顎骨壊死様病変モデルの開発2019

    • Author(s)
      黒嶋伸一郎,早野博紀,右藤友督,玉城沙貴,小堤涼平,澤瀬 隆
    • Organizer
      第5回日本骨免疫学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高機能化末梢血由来単核細胞移植が高頻度発現型マウスBRONJ様病変モデルに与える影響2019

    • Author(s)
      黒嶋伸一郎,佐々木宗輝,早野博紀,玉城沙貴,澤瀬 隆
    • Organizer
      第39回日本骨形態計測学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨吸収抑制薬と抗癌剤の併用投与がマウス抜歯窩治癒に与える影響2019

    • Author(s)
      早野博紀,黒嶋伸一郎,玉城沙貴,澤瀬 隆
    • Organizer
      第39回日本骨形態計測学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] デノスマブ関連顎骨壊死の寛解には脈管新生よりも組織修復性マクロファージの集積が重要な役割を果たす2019

    • Author(s)
      玉城沙貴,黒嶋伸一郎,早野博紀,井上真愛弥,佐々木宗輝,澤瀬 隆
    • Organizer
      第49回公益社団法人日本口腔インプラント学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗RANKL抗体製剤の休止が高頻度発現型マウス顎骨壊死様病変に与える影響2019

    • Author(s)
      黒嶋伸一郎,玉城沙貴,早野博紀,井上真愛弥,澤瀬 隆
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 免疫病理組織所見が異なるビスフォスフォネート製剤と抗RANKL抗体誘発性顎骨壊死様病変2019

    • Author(s)
      早野博紀,黒嶋伸一郎,玉城沙貴,井上真愛弥,澤瀬 隆
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of cell transplantation on BRONJ-like lesions are quite different between SVF and QQ-MNCs2019

    • Author(s)
      Kuroshima S, Sasaki M, Nakajima K, Sawase T
    • Organizer
      29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Upregulated macrophage distribution in reduced osteonecrosis of the jaw-like lesions by the discontinuation of anti-RANKL antibody in mice2019

    • Author(s)
      Tamaki S, Kuroshima S, Hayano H, Inoue M, Nakajima K, Sasaki M, Sawase T
    • Organizer
      29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation between phosphorus concentration and autophagy2019

    • Author(s)
      Sasaki M, Kuroshima S, Sawase T
    • Organizer
      29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンポジウム1.適切な介入を支える基礎研究・臨床研究 ―薬剤関連顎骨壊死に関する基礎・トランスレーショナル・臨床研究の最前線―2019

    • Author(s)
      黒嶋伸一郎
    • Organizer
      特定非営利活動法人 日本がん口腔支持療法学会第5回学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 破骨細胞分化因子に対する中和抗体の休薬が抜歯窩治癒と長管骨微小環境に与える影響2019

    • Author(s)
      玉城沙貴,黒嶋伸一郎,早野博紀,佐々木宗輝,井上真愛弥,澤瀬 隆
    • Organizer
      公益社団法人口腔インプラント学会第36回九州支部学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Medication-related Osteonecrosis of the Jaw -Pathology, Pathogenesis and Treatment Strategies-2019

    • Author(s)
      Kuroshima S
    • Organizer
      60th Anniversary of the KAP & 6th Biennial Joint Congress of KAP-CPS-JPS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 薬剤関連顎骨壊死の病因解明と治療法開発に向けて2018

    • Author(s)
      黒嶋伸一郎
    • Organizer
      第17回松本ボーンフォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 補綴治療に求められる骨質を科学する.「骨質を基盤とした補綴歯科治療戦略は必要か」2018

    • Author(s)
      黒嶋伸一郎
    • Organizer
      公益社団法人日本補綴歯科学会 第127回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨吸収抑制薬がマウスの抜歯窩治癒に与える影響2018

    • Author(s)
      早野博紀,黒嶋伸一郎,佐々木宗輝,玉城沙貴,澤瀬 隆
    • Organizer
      公益社団法人日本補綴歯科学会 第127回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗癌剤の濃度依存性に増大するビスフォスフォネート製剤関連顎骨壊死の有病率2018

    • Author(s)
      黒嶋伸一郎,佐々木宗輝,早野博紀,玉城沙貴,澤瀬 隆
    • Organizer
      第38回日本骨形態計測学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] BP製剤と抗RANKL抗体製剤がマウス抜歯窩治癒に与える影響2018

    • Author(s)
      早野博紀,黒嶋伸一郎,玉城沙貴,澤瀬 隆.
    • Organizer
      第38回日本骨形態計測学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] QQ-MNC移植は高頻度発現型マウスBRONJ様病態を緩解させる2018

    • Author(s)
      黒嶋伸一郎,佐々木宗輝,住田吉慶,朝比奈 泉,澤瀬 隆
    • Organizer
      第4回日本骨免疫学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ビスフォスフォネート製剤関連顎骨壊死の有病率は抗癌剤の濃度依存性に増大する2018

    • Author(s)
      黒嶋伸一郎,佐々木宗輝,早野博紀,玉城沙貴,澤瀬 隆
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨吸収抑制薬と抗癌剤の併用投与がマウス抜歯窩治癒に与える影響2018

    • Author(s)
      早野博紀,黒嶋伸一郎,玉城沙貴,稲葉菜緒,澤瀬 隆
    • Organizer
      第36回日本骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 口腔インプラント治療と研究をつなぐ.「骨質を基軸とした新規インプラントの開発とインプラント-薬剤関連顎骨壊死の病態解明に向けた取り組み」2018

    • Author(s)
      黒嶋伸一郎
    • Organizer
      平成30年度公益社団法人日本補綴歯科学会九州支部学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bisphosphonate-related osteonecrosis of the jaw-like lesions in prevalently induced in a chemotherapeutic dose-dependent manner in mice2018

    • Author(s)
      Kuroshima S, Sasaki M, Hayano H, Tamaki S, Sawase T
    • Organizer
      28th Annual scientific meeting of the Australian and New Zealand Bone and Mineral Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of local PTH administration on maxillary bone around implants in osteoporotic rats2018

    • Author(s)
      Inaba N, Kuroshima S, Uto Y, Uchida Y, Sawase T
    • Organizer
      28th Annual scientific meeting of the Australian and New Zealand Bone and Mineral Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of phosphorus concentration on osteocyte senescence2018

    • Author(s)
      Sasaki M, Kuroshima S, Sawase T
    • Organizer
      28th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢患者に対するプレシジョンインプラント補綴治療の提案2018

    • Author(s)
      黒嶋伸一郎
    • Organizer
      第48回公益社団法人日本口腔インプラント学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ビスフォスフォネート製剤とデノスマブ誘発性顎骨壊死の病因・病態は脈管形成依存性に異なる2018

    • Author(s)
      早野博紀,黒嶋伸一郎,佐々木宗輝,玉城沙貴,澤瀬 隆
    • Organizer
      第48回公益社団法人日本口腔インプラント学会学術大会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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