| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
|
|---|
| Outline of Final Research Achievements |
Teeth are formed by the interrelationship between epithelial and mesenchymal cells. However, if epithelial-mesenchymal transition (EMT) which induces mesenchymal cells from epithelial cells is used, organ will generate from single epithelial cell. In our previous study, we found that Sox21 KO mice induce EMT. Therefore, in this study, we analyze the mechanism of EMT in hard tissue formation.
At first, Sox21 was expressed in T and B cells.
Therefore, when macrophages and lymphocytes with suppressed expression of Sox21 were co-cultured, osteoclast differentiation was enhanced. This indicates that while Sox21 deficiency causes EMT, it also promotes osteoclast differentiation and causes osteogenesis imperfecta-like symptoms.
|
