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Study for the standardization of the fatigue treatment in end-of-life stage cancer patients

Research Project

Project/Area Number 18H03023
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionKyoto University

Principal Investigator

Miyazaki Kikuko  京都大学, 医学研究科, 非常勤講師 (70464229)

Co-Investigator(Kenkyū-buntansha) 堀松 高博  京都大学, 医学研究科, 特定講師 (40511829)
鈴鴨 よしみ  東北大学, 医学系研究科, 准教授 (60362472)
中山 健夫  京都大学, 医学研究科, 教授 (70217933)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywordsがん終末期 / 倦怠感治療 / 標準治療 / RCT / ステロイド / システマティックレビュー / QOL / エビデンス総体 / 倦怠感 / 診療ガイドライン / QOL評価 / 緩和ケア
Outline of Final Research Achievements

Along with pain and dyspnea, fatigue is an unpleasant symptom that affects the quality of life of terminally ill cancer patients. However, no standardized treatment for fatigue exists. Therefore, we conducted a study to standardize the treatment of fatigue in terminally ill cancer patients through the following three steps.
First, a multicenter, placebo-controlled, double-blind, randomized clinical trial assessing the effects of corticosteroid administration on fatigue and quality of life in patients with advanced cancer evaluated the efficacy of oral betamethasone, at a dose of 4 mg daily. Next, a systematic review was conducted. As the final step, along with two patients, a panel of experts is working to develop recommendations for standardizing the treatment of fatigue in terminally ill cancer patients.

Academic Significance and Societal Importance of the Research Achievements

倦怠感は、痛みや呼吸困難と並んで、がん終末期患者のQOLに影響を与える不快な症状である。緩和ケア臨床医師の経験則に基づいて倦怠感治療がされてきたが、標準化はされていない。そこで倦怠感治療の標準化へ向けた研究を実施した。
研究方法として2つの意義をあげる。まず、臨床研究で倦怠感治療の根拠を検証する(つくる)だけでなく、先行研究を整理してまとめ(つたえ)、臨床でつかってもらえる提言までをも研究計画に組み込んだ研究であった。つぎに、いわゆる社会的弱者と言われている参加者に協力を得るために、今までにない倫理的に配慮した登録システムを構築したことである。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (11 results)

All 2021 2020 2019 2018 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] A qualitative research study in Japan investigating patients’ experience with metastatic castration-resistant prostate cancer: from diagnosis to decision for Ra-223 treatment.2021

    • Author(s)
      Akakura K, Uemura H , Miyazaki K, Stroupe A , Seo C, Uzumcu A & Ledesma DA
    • Journal Title

      Future Oncology.

      Volume: 17 Issue: 36 Pages: 5103-5118

    • DOI

      10.2217/fon-2021-0773

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mindset modification of community pharmacists in a collaborative relationship between a major hospital and neighboring community pharmacies: a qualitative study.2019

    • Author(s)
      Hinata M, Miyazaki K, Okada H, Nakayama T.
    • Journal Title

      BMC Health Serv Res.

      Volume: 19(1) Issue: 1 Pages: 487-487

    • DOI

      10.1186/s12913-019-4253-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trends in descriptions of palliative care in the cancer clinical practice guidelines before and after enactment of the Cancer Control Act (2007): content analysis.2019

    • Author(s)
      Hinata M, Miyazaki K, Kanazawa N, Kito K, Kiyoto S, Konda M, Kuriyama A, Mori H, Nakaoka S, Okumura A, Tokumasu H, Nakayama
    • Journal Title

      BMC Palliat Care

      Volume: 12;18(1): Issue: 1

    • DOI

      10.1186/s12904-019-0391-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Issues in the practice of quality-of-life assessment research: A qualitative study for use in considering education methods.2021

    • Author(s)
      Kikuko Miyazaki
    • Organizer
      The 27th Annual Conference of the International Society for Quality of Life Research.
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] QOL評価の活用方法:Minimally Important Difference (MID) の観点から2020

    • Author(s)
      宮崎貴久子
    • Organizer
      日本疫学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A Study about Palliative Care’s Practical Use in Clinical Practice in EORTC QLQ-C15-PAL : An Investigation into Minimally Important Difference (MID).2019

    • Author(s)
      Kikuko Miyazaki, Yoshimi Suzukamo, Masayuki Ikenaga, Shozo Ohsumi, Mari Saito, Kojiro Shimozuma, Takeo Nakayama.
    • Organizer
      The 25th Annual Conference of the International Society for Quality of Life Research.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん終末期における倦怠感治療の標準化:臨床試験からエビデンス総体へ向けた研究経過報告2019

    • Author(s)
      宮崎貴久子、鈴鴨よしみ、堀松高博、中山健夫
    • Organizer
      日本臨床知識学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Issues in implementing QOL assessment research2018

    • Author(s)
      Kikuko Miyazaki, Tatsuto Nishigori, Nobuichiro Tamura, Rika Hayashida, Shinichi Noto, Yoshimi Suzukamo.
    • Organizer
      International Society for Quality of Life
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quality of Life (QOL)調査 臨床における最小重要差(MID)2018

    • Author(s)
      宮崎貴久子
    • Organizer
      日本薬剤疫学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Remarks] PASQol臨床試験:終末期倦怠感治療のRCT

    • URL

      http://hi.med.kyoto-u.ac.jp/pasqol.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] PASQol Protocol

    • URL

      http://hi.med.kyoto-u.ac.jp/HP_PASQol_Protcol_0715.pdf

    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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