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Perfluorinated alkyl substances exposure and onset of puberty - birth cohort and in vitro studies

Research Project

Project/Area Number 18H03035
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionHokkaido University

Principal Investigator

Ikeda Atsuko  北海道大学, 環境健康科学研究教育センター, 特任教授 (00619885)

Co-Investigator(Kenkyū-buntansha) 小島 弘幸  北海道医療大学, 薬学部, 教授 (10414286)
小林 澄貴  北海道大学, 環境健康科学研究教育センター, 特任講師 (10733371)
守屋 仁彦  北海道大学, 医学研究院, 客員准教授 (20374233)
宮下 ちひろ  北海道大学, 環境健康科学研究教育センター, 特任准教授 (70632389)
岸 玲子  北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449)
アイツバマイ ゆふ  北海道大学, 環境健康科学研究教育センター, 特任講師 (90752907)
池中 良徳  北海道大学, 獣医学研究院, 准教授 (40543509)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords内分泌かく乱作用 / 有機フッ素化合物 / 出生コーホート / 遺伝子多型 / 核内受容体 / 細胞アッセイ系 / 生殖ホルモン / 遺伝子発現解析 / 内分泌かく乱物質 / 第二次性徴 / 内分泌かく乱
Outline of Final Research Achievements

Per and polyfluorinated substances (PFAS) is a class of chemicals known for "endocrine disrupting” effects. A birth cohort study examined the effects of prenatal PFAS exposure on gonadal function and onset of puberty. Prenatal PFAS exposure lowered testosterone levels and increased progesterone and INSL3 levels at birth. PFTrDA delayed the age of menarche in girls. ESR1 polymorphisms may modulate the effects of PFAS on sexual differentiation. In vitro study, PFOA and PFNA showed agonist activity of ERalpha and PPARalpha. PFOA and PFNA were agonists of ERalpha and PPARalpha, whereas no agonist of antagonist activation of ERbeta, AR, GR, TR. Up or down regulation of about 800-intracellular gene expression were observed upon PFOA exposure, including PPARalpha receptors signaling genes and cytokines and IgE related genes.

Academic Significance and Societal Importance of the Research Achievements

有機フッ素化合物(PFAS)は、いわゆる「内分泌かく乱作用」が懸念される物質である。本研究では、比較的低濃度曝露であっても、胎児期のPFAS曝露が児の出生時の性ホルモン値を上げ、または下げ、女児の初潮開始年齢を遅らせる内分泌かく乱作用をヒトで示した。また、胎児期のPFAS曝露による性分化への影響には遺伝子多型による修飾がある、したがって影響を受けやすい脆弱な集団の可能性を示唆した。メカニズムとしてはPFASは核内受容体の細胞内シグナル伝達を引き起こし、遺伝子発現量を変化させた。既に世界的な規制対象であるPFOSやPFOA以外の化合物も、ヒトへの健康影響の可能性があることを示唆した。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (56 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (26 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 26 results,  Open Access: 20 results) Presentation (28 results) (of which Int'l Joint Research: 19 results,  Invited: 6 results) Remarks (1 results)

  • [Int'l Joint Research] University of Antwerp(ベルギー)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Secular trends of urinary phthalate metabolites in 7-year old children and association with building characteristics: Hokkaido study on environment and children's health2021

    • Author(s)
      Ketema Rahel Mesfin、Ait Bamai Yu、Ikeda-Araki Atsuko、Saito Takeshi、Kishi Reiko
    • Journal Title

      International Journal of Hygiene and Environmental Health

      Volume: 234 Pages: 113724-113724

    • DOI

      10.1016/j.ijheh.2021.113724

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children2020

    • Author(s)
      Araki Atsuko、Ait Bamai Yu、Bastiaensen Michiel、Van den Eede Nele、Kawai Toshio、Tsuboi Tazuru、Miyashita Chihiro、Itoh Sachiko、Goudarzi Houman、Konno Satoshi、Covaci Adrian、Kishi Reiko
    • Journal Title

      Environmental Research

      Volume: 183 Pages: 109212-109212

    • DOI

      10.1016/j.envres.2020.109212

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of exposure to prenatal phthalate esters and bisphenol A and polymorphisms in the ESR1 gene with the second to fourth digit ratio in school-aged children: Data from the Hokkaido study2020

    • Author(s)
      Nishimura Yoko、Moriya Kimihiko、Kobayashi Sumitaka、Araki Atsuko、Sata Fumihiro、Mitsui Takahiko、Itoh Sachiko、Miyashita Chihiro、Cho Kazutoshi、Kon Masafumi、Nakamura Michiko、Kitta Takeya、Murai Sachiyo、Kishi Reiko、Shinohara Nobuo
    • Journal Title

      Steroids

      Volume: 159 Pages: 108637-108637

    • DOI

      10.1016/j.steroids.2020.108637

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endocrine-Distributing Chemicals and Reproductive Function2020

    • Author(s)
      Araki Atsuko、Jensen Tina Kold
    • Journal Title

      Health Impacts of Developmental Exposure to Environmental Chemicals

      Volume: 5 Pages: 101-129

    • DOI

      10.1007/978-981-15-0520-1_5

    • ISBN
      9789811505195, 9789811505201
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: The Hokkaido study on environment and children's health.2020

    • Author(s)
      Ait Bamai Yu、Goudarzi Houman、Araki Atsuko、Okada Emiko、Kashino Ikuko、Miyashita Chihiro、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 143 Pages: 105979-105979

    • DOI

      10.1016/j.envint.2020.105979

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of CLIC4 on Fucoxanthinol-Induced Apoptosis in Human Colorectal Cancer Cells2020

    • Author(s)
      Yokoyama Reo、Kojima Hiroyuki、Takai Rie、Ohta Tohru、Maeda Hayato、Miyashita Kazuo、Mutoh Michihiro、Terasaki Masaru
    • Journal Title

      Nutrition and Cancer

      Volume: 73 Issue: 5 Pages: 889-898

    • DOI

      10.1080/01635581.2020.1779760

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice2020

    • Author(s)
      Terasaki Masaru、Uehara Osamu、Ogasa Shinya、Sano Taishi、Kubota Atsuhito、Kojima Hiroyuki、Tanaka Takuji、Maeda Hayato、Miyashita Kazuo、Mutoh Michihiro
    • Journal Title

      Carcinogenesis

      Volume: 42 Issue: 2 Pages: 210-219

    • DOI

      10.1093/carcin/bgaa100

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study2020

    • Author(s)
      Kenda Masa、Karas Kuzelicki Natasa、Iida Mitsuru、Kojima Hiroyuki、Sollner Dolenc Marija
    • Journal Title

      Environmental Health Perspectives

      Volume: 128 Issue: 10 Pages: 107005-107005

    • DOI

      10.1289/ehp6596

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes2020

    • Author(s)
      Tsugoshi Yukie、Watanabe Yoko、Tanikawa Yuka、Inoue Chika、Sugihara Kazumi、Kojima Hiroyuki、Kitamura Shigeyuki
    • Journal Title

      Chemico-Biological Interactions

      Volume: 327 Pages: 109148-109148

    • DOI

      10.1016/j.cbi.2020.109148

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuity of Tumor Microenvironmental Suppression in AOM/DSS Mice by Fucoxanthin May Be Able to Track With Salivary Glycine2020

    • Author(s)
      TERASAKI MASARU、KIMURA RYOTA、KUBOTA ATSUHITO、KOJIMA HIROYUKI、TANAKA TAKUJI、MAEDA HAYATO、MIYASHITA KAZUO、MUTOH MICHIHIRO
    • Journal Title

      In Vivo

      Volume: 34 Issue: 6 Pages: 3205-3215

    • DOI

      10.21873/invivo.12156

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study2020

    • Author(s)
      Kashino Ikuko、Sasaki Seiko、Okada Emiko、Matsuura Hideyuki、Goudarzi Houman、Miyashita Chihiro、Okada Eisaku、Ito Yoichi M.、Araki Atsuko、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 136 Pages: 105355-105355

    • DOI

      10.1016/j.envint.2019.105355

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary fucoxanthin induces anoikis in colorectal adenocarcinoma through suppressing integrin signaling in a murine colorectal cancer model.2020

    • Author(s)
      3.Terasaki M, Ikuta M, Kojima H, Tanaka T, Maeda H, Miyashita K, Mutoh M.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 1 Pages: 90-90

    • DOI

      10.3390/jcm9010090

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor.2020

    • Author(s)
      Park C, Song H, Choi J, Sim S, Kojima H, Park M, Iida M, Lee YJ.
    • Journal Title

      Environmental Pollution

      Volume: 260 Pages: 114036-114036

    • DOI

      10.1016/j.envpol.2020.114036

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of benzotriazole ultraviolet stabilizers on rat PXR, CAR and PPARα transcriptional activities2019

    • Author(s)
      Watanabe Yoko、Hattori Shoko、Fujino Chieri、Tachibana Ken、Kojima Hiroyuki、Yoshinari Kouichi、Kitamura Shigeyuki
    • Journal Title

      Fundamental Toxicological Sciences

      Volume: 6 Issue: 2 Pages: 57-63

    • DOI

      10.2131/fts.6.57

    • NAID

      130007616171

    • ISSN
      2189-115X
    • Year and Date
      2019-03-19
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study2019

    • Author(s)
      Itoh Sachiko、Araki Atsuko、Miyashita Chihiro、Yamazaki Keiko、Goudarzi Houman、Minatoya Machiko、Ait Bamai Yu、Kobayashi Sumitaka、Okada Emiko、Kashino Ikuko、Yuasa Motoyuki、Baba Toshiaki、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 133 Pages: 105139-105139

    • DOI

      10.1016/j.envint.2019.105139

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of prenatal sex hormones on behavioral sexual dimorphism.2019

    • Author(s)
      Mitsui T, Araki A, Miyashita C, Ito S, Ikeno T, Sasaki S, Kitta T, Moriya K, Cho K, Morioka K, Kishi R, Shinohara N, Takeda M, Nonomura K.
    • Journal Title

      Pediatr Int.

      Volume: 61 Issue: 2 Pages: 140-146

    • DOI

      10.1111/ped.13756

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study2019

    • Author(s)
      Ait Bamai Yu、Bastiaensen Michiel、Araki Atsuko、Goudarzi Houman、Konno Satoshi、Ito Sachiko、Miyashita Chihiro、Yao Yiming、Covaci Adrian、Kishi Reiko
    • Journal Title

      Environment International

      Volume: 131 Pages: 105003-105003

    • DOI

      10.1016/j.envint.2019.105003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARalpha-mediated transcriptional activation.2019

    • Author(s)
      1.Fujino C, Watanabe Y, Sanoh S, Hattori S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.
    • Journal Title

      Food and Chemical Toxicology

      Volume: 133 Pages: 110792-110792

    • DOI

      10.1016/j.fct.2019.110792

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of PXR, CAR and PPARalpha by pyrethroid pesticides and effect of the metabolism by rat liver microsomes.2019

    • Author(s)
      2.Fujino C, Watanabe Y, Sanoh S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.
    • Journal Title

      Heliyon

      Volume: 5 Issue: 9 Pages: e02466-e02466

    • DOI

      10.1016/j.heliyon.2019.e02466

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution of 58 semi-volatile organic chemicals in the gas phase and three particle sizes in indoor air and house dust in residential buildings during the hot season in Japan2019

    • Author(s)
      3.Takeuchi S, Tanaka-Kagawa T, Saito I, Kojima H, Jinno H
    • Journal Title

      BPB reports

      Volume: 2(6) Pages: 91-98

    • NAID

      130007940489

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study.2019

    • Author(s)
      Nishimura Y, Moriya K, Kobayashi S, Araki A, Sata F, Mitsui T, Itoh S, Miyashita C, Cho K, Kon M, Nakamura M, Kitta T, Murai S, Kishi R, Shinohara N.
    • Journal Title

      Steroids

      Volume: 141 Pages: 55-62

    • DOI

      10.1016/j.steroids.2018.11.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors2019

    • Author(s)
      Hiroyuki Kojima, Shinji Takeuchi, Seigo Sanoh, Katsuhiro Okuda, Shigeyuki Kitamura, Naoto Uramaru, Kazumi Sugihara, Kouichi Yoshinari
    • Journal Title

      Toxicology, 413(2),48-55,

      Volume: 413 Pages: 48-55

    • DOI

      10.1016/j.tox.2018.12.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children’s Health.2018

    • Author(s)
      Tsai Meng-Shan、Miyashita Chihiro、Araki Atsuko、Itoh Sachiko、Bamai Yu、Goudarzi Houman、Okada Emiko、Kashino Ikuko、Matsuura Hideyuki、Kishi Reiko
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 15 Issue: 5 Pages: 989-989

    • DOI

      10.3390/ijerph15050989

    • NAID

      120006533153

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health2018

    • Author(s)
      Mitsui Takahiko、Araki Atsuko、Goudarzi Houman、Miyashita Chihiro、Ito Sachiko、Sasaki Seiko、Kitta Takeya、Moriya Kimihiko、Cho Kazutoshi、Morioka Keita、Kishi Reiko、Shinohara Nobuo、Takeda Masayuki、Nonomura Katsuya
    • Journal Title

      American Journal of Human Biology

      Volume: - Issue: 4

    • DOI

      10.1002/ajhb.23127

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 危険ドラッグ検査の化学分析を補完する薬物受容体アッセイ及び植物片DNA解析の有用性評価2018

    • Author(s)
      武内伸治、高橋正幸、藤本啓、佐藤正幸、小島弘幸
    • Journal Title

      北海道公衆衛生学雑誌

      Volume: 32 Pages: 85-91

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 環境化学物質による次世代の性ホルモンへの影響2018

    • Author(s)
      荒木敦子、伊藤佐智子、 宮下ちひろ、 湊屋街子、 岸玲子
    • Journal Title

      日本衛生学雑誌

      Volume: 73 Pages: 313-321

    • NAID

      130007492090

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Cell-based assay法を用いたUV吸収剤のホルモン受容体を介したエストロゲン・抗アンドロゲン作用の検出2020

    • Author(s)
      1.桜木優太、寺崎将、小島弘幸
    • Organizer
      日本薬学会北海道支部第147回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ベンゾトリアゾール系UV吸収剤のAhRアゴニスト活性と免疫系に及ぼす影響2020

    • Author(s)
      2.窪田篤人、桜木優太、寺崎将、室本竜太、高田秀重、小島弘幸
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Urinary cotinine levels of Japanese school children and associated demographic characteristics: the Hokkaido Study2020

    • Author(s)
      Minatoya M., Miyashita C., Araki A., Ait Bamai Y., Kobayashi S., Kishi R
    • Organizer
      10th VIRTUAL International Conference Children’s Health and Environment
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phthalates in house dust and their metabolites in children’s urine summary of the finding in Japan.2020

    • Author(s)
      Ait Bamai Y., Araki A., Kishi R
    • Organizer
      30th Annual Meeting International Society of Exposure Science (ISES)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environmental Chemical Exposure and Children’s Health The Hokkaido Study2020

    • Author(s)
      Araki A
    • Organizer
      8th Sapporo Summer Symposium for One Health (SaSSOH)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biomonitoring of Phthalate Metabolites in Children: The Hokkaido Study2020

    • Author(s)
      Ketema R.M., Ait Bamai Y., Araki A, Saito T, Kishi R
    • Organizer
      8th Sapporo Summer Symposium for One Health
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mercury levels in pregnant women in Japanese general population and children’s birth size.2020

    • Author(s)
      Araki A., Miyashita C., Kobayashi S., Kishi R
    • Organizer
      Annual Conference of the International Society for Environmental Epidemiology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PFAS and BPA exposures in utero and their alteration of DNA methylation at birth: the Hokkaido Study in collaboration with Taiwan cohorts.2020

    • Author(s)
      Araki A., Miyashita C., Miura R., Wang SL., ChenML., Kishi R
    • Organizer
      32nd Annual Conference of the International Society for Environmental Epidemiology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changing trends in urinary phthalate metabolites in elementary school children; 2012-20172020

    • Author(s)
      Ketema R.M., Ait Bamai Y., Araki A, Saito T, Kishi R
    • Organizer
      32nd Annual Conference of the International Society for Environmental Epidemiology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 妊娠中有機フッ素化合物曝露と臍帯血中の性ホルモン濃度との関連:遺伝環境相互作用の影響-北海道スタディ2020

    • Author(s)
      小林澄貴, 佐田文宏, 荒木敦子, 宮下ちひろ, 伊藤佐智子, グウダルジホウマヌ, 岩崎雄介, 三井貴彦, 守屋仁彦, 篠原信雄, 長和俊, 岸玲子
    • Organizer
      第30回日本疫学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マイクロプラスチック由来化学物質におけるヒトエストロゲン受容体alpha/beta;アゴニスト活性の比較2020

    • Author(s)
      桜木優太、寺崎将、武内伸治、小島弘幸
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Prenatal environmental chemical exposure on children’s health: The Hokkaido Study.2019

    • Author(s)
      Atsuko Araki
    • Organizer
      CHEMICAL HAZARD Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of prenatal exposure to persistent organic pollutants on children’s health in the Hokkaido Study on Environment and Children’s Health2019

    • Author(s)
      Chihiro Miyashita, and Reiko Kishi
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Prenatal Exposure to Perfluoroalkyl Substances (PFAS) on Childhood Allergies and Infectious Diseases; Hokkaido Study2019

    • Author(s)
      Yu Ait Bamai, Houman Goudarzi, Emiko Okada, Atsuko Araki, Chihiro Miyashita, Hideyuki Matsuura, and Reiko Kishi
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of perfluorocarboxylic acids on transcriptional activity via human nuclear receptors and gene expression in human macrophage-like THP-1 cells.2019

    • Author(s)
      Kojima H, Takeuchi S, Okuda K, Muromoto R, Kishi R, Araki A.
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants (Dioxin2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distribution of 58 semi-volatile organic chemicals in the gas phase and three particle sizes in indoor air and house dust in residential buildings during the hot season in Japan.2019

    • Author(s)
      Takeuchi S, Tanaka-Kagawa T, Saito I, Kojima H, Jinno H.
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants (Dioxin2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of dioxin-related compounds in trace biological samples using highly sensitive cells, DR-EcoScreenHS bioassay.2019

    • Author(s)
      Matsuda R, Nakamura M, Kojima H, Iida M.
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants (Dioxin2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 環境化学物質による核内受容体活性の探索と免疫毒性作用2019

    • Author(s)
      小島弘幸
    • Organizer
      第162回日本獣医学会学術集会(日本比較薬理学・毒性学会シンポジウム)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The Hokkaido Study on Environment and Children’s Health: Overview of the study and collaborations with cohorts in Asia2019

    • Author(s)
      Atsuko Araki, Chihiro Miyashita, Machiko Minatoya, and Reiko Kishi.
    • Organizer
      ISESISEE-AC2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mixture Chemical Exposure in Utero and Boys Reproductive Hormone Levels at Birth: the Hokkaido Study2019

    • Author(s)
      Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Takahiko Mitsui, Houman Goudarzi, Kazutoshi Cho, Kimihiko Moriya, Tamie Nakajima, Yusuke Iwasaki, Tsuguhide Hori, Junboku Kajiwara, Nobuo Shinohara, Reiko Kishi.
    • Organizer
      ISESISEE-AC2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胎児期の環境化学物質への混合曝露による児の性ホルモンへの影響.2019

    • Author(s)
      荒木敦子、 宮下ちひろ、 伊藤佐智子、 三井貴彦、 ホウマヌゴウダルジ、 長和俊、 守屋仁彦、 那須民江、岩崎雄介、堀就英、梶原淳睦、篠原信雄、 岸玲子
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小型携帯サンプラーを用いた学童の化学物質曝露と自宅環境中濃度との関連2018

    • Author(s)
      荒木敦子、河合俊夫、坪井樹、アイツバマイゆふ、岸玲子
    • Organizer
      第91回日本産業衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 核内受容体活性を指標とした化学物質の毒性影響評価2018

    • Author(s)
      小島弘幸
    • Organizer
      生物化学的測定研究会 第23回学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] In vitro and in silico studies on PPARα/γand PXR activation by di-(2-ethylhexyl) phthalate and its metabolites2018

    • Author(s)
      Kojima H, Okuda K, Uramaru N, Kitamura S, Takeuchi S, Muromoto R, Sugihara K, Kishi R, Araki A.
    • Organizer
      Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of essential oil constituents on in vitro transcriptional activity via estrogen and androgen receptors, and in an in silico molecular docking study2018

    • Author(s)
      Takeuchi S, Okuda K, Sugihara K, Kojima H.
    • Organizer
      Conference of International Society for Environmental Epidemiology and International Society of Exposure Science-Asia Chapter 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mixed phthalate Ester and Phosphate Flame Retardant Exposure and Asthma and Allergines in School Children2018

    • Author(s)
      Araki A., Ait Bamai Y., Bastiaensen M., Van den Eede N., Kawai T., Tsuboi T., Itoh S., Miyashita C., Covaci A., kishi R.
    • Organizer
      The Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Prenatal Exposure to Perfluoroalkyl Substances (PFASs) on Childhood Infectious Diseases Up to 7 years of age: The Hokkaido Study2018

    • Author(s)
      Ait Bamai Y., Araki A., Okada E., Kashino I., Miyashita C., Goudarzi H., Matsuura H., Kishi R.
    • Organizer
      The Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒトマクロファージ様THP-1細胞の遺伝子発現に及ぼす核内受容体アゴニストの曝露影響2018

    • Author(s)
      小島弘幸、武内伸治、室本竜太、岸玲子、荒木敦子
    • Organizer
      第25回日本免疫毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 環境と子どもの健康に関する北海道研究・北海道スタディ「これまでにわかったこと」

    • URL

      https://www.cehs.hokudai.ac.jp/hokkaidostudy/report/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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