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Association between equol, a metabolite of soy protein, and atherosclerosis in a community-based general population

Research Project

Project/Area Number 18H03048
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionShiga University of Medical Science

Principal Investigator

藤吉 朗  滋賀医科大学, 医学部, 客員教授 (10567077)

Co-Investigator(Kenkyū-buntansha) 近藤 慶子  滋賀医科大学, 医学部, 助教 (20566567)
門田 文  滋賀医科大学, 医学部, 准教授 (60546068)
有馬 久富  福岡大学, 医学部, 教授 (20437784)
上島 弘嗣  滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483)
三浦 克之  滋賀医科大学, 医学部, 教授 (90257452)
伊藤 隆洋  滋賀医科大学, 医学部, 客員助教 (40778213)
国村 彩子  滋賀医科大学, 医学部, 客員助教 (30803952)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywordsエクオール / 大豆イソフラボン / 動脈硬化 / 大豆たんぱく
Outline of Annual Research Achievements

本研究の目的は、潜在性動脈硬化・冠動脈疾患に関する既存研究の保存検体とデータを駆使し、日本人一般地域住民のエクオールとイソフラボン血中濃度を測定することで、動脈硬化進展・冠動脈疾患との関連、エクオール産生者と腸内細菌との関連、エクオールが動脈硬化や認知機能に及ぼす機序を検証し、ヒトにおけるエクオールと動脈硬化との関連を多角的に評価・検討することである。
男性については1000名あまりの測定(尿、血液)をもとに2021年度、第53回日本動脈硬化学会総会・学術集会(2021年10月23・24日)にてエクオール産生状況やエクオール濃度と冠動脈石灰化の関連について発表した。
またピッツバーグ大学の共同研究者とエクオールのデータを用いた日本人地域住民男性の疫学研究論文を英文雑誌に発表した(International Journal of Cardiology 2022;352:158-164)。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

男性については上述の通りほぼ予定通りに進行している。女性についてはコロナ蔓延の影響で、対象者への検査を延期していた時期があり、そのため検体(尿・血液)の収集が遅れている。なお計画の一部である腸内細菌の評価も保存検体を用いて行うことができた。

Strategy for Future Research Activity

男性については予備解析が完了し上述の通り学会発表も終えた。今後、さらなる解析を行い論文化を進めて行く。女性については、2022年度6月ころを目安に600名ほどの尿・血液検体が送付できる目途をたて、解析できるデータの整備を目指す。

Report

(4 results)
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(33 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (19 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 16 results,  Open Access: 9 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] Department of Epidemiology/Graduate School of Public Health/University of Pittsburgh(米国)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification2022

    • Author(s)
      Ganbaatar Namuun、Kadota Aya、Hisamatsu Takashi、Araki Shinichi、Kume Shinji、Fujiyoshi Akira、Kadowaki Sayaka、Torii Sayuki、Kondo Keiko、Segawa Hiroyoshi、Salman Ebtehal、Miyazawa Itsuko、Yamamoto Takashi、Nakagawa Yoshihisa、Maegawa Hiroshi、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research Group
    • Journal Title

      J Atheroscler Thromb

      Volume: - Issue: 9 Pages: 1359-1371

    • DOI

      10.5551/jat.63030

    • NAID

      130008106841

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-09-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of equol producing status with aortic calcification in middle-aged Japanese men: The ERA JUMP study2022

    • Author(s)
      Zhang Xiao、Fujiyoshi Akira、Ahuja Vasudha、Vishnu Abhishek、Barinas-Mitchell Emma、Kadota Aya、Miura Katsuyuki、Edmundowicz Daniel、Ueshima Hirotsugu、Sekikawa Akira
    • Journal Title

      International Journal of Cardiology

      Volume: 352 Pages: 158-164

    • DOI

      10.1016/j.ijcard.2022.01.065

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Is Measuring Risk Marker Progression Useful for Cardiovascular Disease Prediction?2021

    • Author(s)
      Fujiyoshi Akira、Zaid Maryam、Barinas-Mitchell Emma
    • Journal Title

      Cerebrovascular Diseases

      Volume: 50 Pages: 752-755

    • DOI

      10.1159/000517869

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] How Is Socioeconomic Status Associated With the Incidence of Heart Failure?2021

    • Author(s)
      Higashiyama Aya、Fujiyoshi Akira
    • Journal Title

      Circ J

      Volume: 85 Issue: 9 Pages: 1553-1554

    • DOI

      10.1253/circj.cj-21-0534

      10.1253/circj.CJ-21-0534

    • NAID

      130008077961

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis2021

    • Author(s)
      Hisamatsu Takashi、Ohkubo Takayoshi、Hozawa Atsushi、Fujiyoshi Akira、Torii Sayuki、Segawa Hiroyoshi、Kondo Keiko、Kadota Aya、Takashima Naoyuki、Shitara Satoshi、Arima Hisatomi、Nakagawa Yoshihisa、Watanabe Yoshiyuki、Shiino Akihiko、Nozaki Kazuhiko、Ueshima Hirotsugu、Miura Katsuyuki
    • Journal Title

      Journal of Hypertension

      Volume: 39 Pages: 2030-2039

    • DOI

      10.1097/hjh.0000000000002900

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors Associated with Lower Cognitive Performance Scores Among Older Japanese Men in Hawaii and Japan2021

    • Author(s)
      Naoko Miyagawa, Takayoshi Ohkubo, Akira Fujiyoshi, Akihiko Shiino, Randi Chen, George Webster Ross, Bradley Willcox, Katsuyuki Miura, Hirotsugu Ueshima, Kamal Masaki
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 81 Pages: 403-412

    • DOI

      10.3233/jad-201084

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study2021

    • Author(s)
      Suzuki Harumitsu、Davis-Plourde Kendra、Beiser Alexa、Kunimura Ayako、Miura Katsuyuki、DeCarli Charles、Maillard Pauline、Mitchell Gary F.、Vasan Ramachandran S.、Seshadri Sudha、Fujiyoshi Akira
    • Journal Title

      Circulation: Cardiovascular Imaging

      Volume: 14

    • DOI

      10.1161/circimaging.120.011753

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men2021

    • Author(s)
      Vu Thien、Fujiyoshi Akira、Hisamatsu Takashi、Kadota Aya、Zaid Maryam、Segawa Hiroyoshi、Kondo Keiko、Torii Sayuki、Nakagawa Yoshihisa、Suzuki Tomoaki、Asai Tohru、Miura Katsuyuki、Ueshima Hirotsugu、for the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group
    • Journal Title

      Circ J

      Volume: 85 Issue: 7 Pages: 1076-1082

    • DOI

      10.1253/circj.cj-20-1090

      10.1253/circj.CJ-20-1090

    • NAID

      130008056918

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men2021

    • Author(s)
      Syaifullah AH, Shiino A, Fujiyoshi A, Kadota A, Kondo K, Ito T, Segawa H, Moniruzzaman M, Waki T, Miyagawa N, Tooyama I, Ueshima H, Miura K; SESSA Research Group.
    • Journal Title

      Alcohol

      Volume: 90 Pages: 57-65

    • DOI

      10.1016/j.alcohol.2020.11.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship Between Step Counts and Cerebral Small Vessel Disease in Japanese Men2020

    • Author(s)
      Moniruzzaman Mohammad、Kadota Aya、Segawa Hiroyoshi、Kondo Keiko、Torii Sayuki、Miyagawa Naoko、Fujiyoshi Akira、Hisamatsu Takashi、Watanabe Yoshiyuki、Shiino Akihiko、Nozaki Kazuhiko、Ueshima Hirotsugu、Miura Katsuyuki、on behalf of the SESSA Research Group
    • Journal Title

      Stroke

      Volume: 51 Pages: 3584-3591

    • DOI

      10.1161/strokeaha.120.030141

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperglycemia, duration of diabetes, and intracranial atherosclerotic stenosis by magnetic resonance angiography: The ARIC-NCS study2020

    • Author(s)
      Fujiyoshi Akira、Suri M. Fareed K.、Alonso Alvaro、Selvin Elizabeth、Chu Haitao、Guallar Eliseo、Qiao Ye、Zhang Yiyi、Wasserman Bruce A.、Folsom Aaron R.
    • Journal Title

      Journal of Diabetes and its Complications

      Volume: 34 Pages: 107605-107605

    • DOI

      10.1016/j.jdiacomp.2020.107605

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] "Progression" of a risk factor on cardiovascular outcome: A valuable point, a questionable interpretation2020

    • Author(s)
      Fujiyoshi A.
    • Journal Title

      Eur J Prev Cardiol

      Volume: 27 Pages: 231-233

    • DOI

      10.1177/2047487319880988

    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study2020

    • Author(s)
      Khan Md Maruf Haque、Fujiyoshi Akira、Shiino Akihiko、Hisamatsu Takashi、Torii Sayuki、Suzuki Sentaro、Kunimura Ayako、Segawa Hiroyoshi、Kadota Aya、Ohkubo Takayoshi、Nozaki Kazuhiko、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research Group
    • Journal Title

      J Atheroscler Thromb

      Volume: - Issue: 9 Pages: 00-00

    • DOI

      10.5551/jat.51284

    • NAID

      130007894637

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study2020

    • Author(s)
      Fujiyoshi Akira、Miura Katsuyuki、Ohkubo Takayoshi、Miyagawa Naoko、Saito Yoshino、Miyazawa Itsuko、Shiino Akihiko、Kadota Aya、Kadowaki Sayaka、Hisamatsu Takashi、Torii Sayuki、Takashima Naoyuki、Tooyama Ikuo、Ueshima Hirotsugu
    • Journal Title

      Journal of Epidemiology

      Volume: - Issue: 6 Pages: 00-00

    • DOI

      10.2188/jea.je20180258

      10.2188/jea.JE20180258

    • NAID

      130007852129

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Eczema and Risk of Cardiovascular Disease: Heightened Awareness Needed2019

    • Author(s)
      Fujiyoshi A.
    • Journal Title

      J Atheroscler Thromb

      Volume: 26 Issue: 9 Pages: 760-761

    • DOI

      10.5551/jat.ed109

      10.5551/jat.ED109

    • NAID

      130007699925

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] The effects of renin-angiotensin system inhibitors on mortality, cardiovascular events, and renal events in hypertensive patients with diabetes: a systematic review and meta-analysis of randomized controlled trials.2019

    • Author(s)
      Kunimura A, Himuro N, Fujiyoshi A, Segawa H, Ohnishi H, Saitoh S.
    • Journal Title

      Hypertens Res.

      Volume: 42(5) Pages: 669-680

    • DOI

      10.1038/s41440-019-0234-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men2019

    • Author(s)
      Shitara Satoshi、Fujiyoshi Akira、Hisamatsu Takashi、Torii Sayuki、Suzuki Sentarou、Ito Takahiro、Arima Hisatomi、Shiino Akihiko、Nozaki Kazuhiko、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research group
    • Journal Title

      Stroke

      Volume: 50 Pages: 2967-2969

    • DOI

      10.1161/strokeaha.119.025964

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)2019

    • Author(s)
      Sumi Masaki、Hisamatsu Takashi、Fujiyoshi Akira、Kadota Aya、Miyagawa Naoko、Kondo Keiko、Kadowaki Sayaka、Suzuki Sentaro、Torii Sayuki、Zaid Maryam、Sato Atsushi、Arima Hisatomi、Terada Tomohiro、Miura Katsuyuki、Ueshima Hirotsugu
    • Journal Title

      Journal of Epidemiology

      Volume: [Epub ahead of print] Issue: 6 Pages: 205-212

    • DOI

      10.2188/jea.je20170191

      10.2188/jea.JE20170191

    • NAID

      130007659756

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)2018

    • Author(s)
      Tai P, Fujiyoshi A, Arima H, Tanaka-Mizuno S, Hisamatsu T, Kadowaki S, Kadota A, Zaid M, Sekikawa A, Yamamoto T, Horie M, Miura K, Ueshima H
    • Journal Title

      J Atheroscler Thromb

      Volume: 未定 Issue: 6 Pages: 477-489

    • DOI

      10.5551/jat.42416

    • NAID

      130007382558

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 地域住民男性における大豆イソフラボン代謝産物エクオールと冠動脈石灰化との横断的関連:SESSA研究2021

    • Author(s)
      藤吉 朗、三浦克之、門田 文、有馬久富、関川 暁、近藤慶子、門脇紗也佳、岡見雪子、鈴木春満、久松隆史、中川義久、東山綾、岡村智教、上島弘嗣
    • Organizer
      第53回日本動脈硬化学会総会・学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Recent lipid management for the prevention of atherosclerotic cardiovascular diseases in Asia2021

    • Author(s)
      Akira Fujiyoshi
    • Organizer
      International Symposium on Atherosclerosis (ISA)2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 連続変数危険因子のprogression評価モデルに関する考察2020

    • Author(s)
      藤吉 朗
    • Organizer
      第56回日本循環器病予防学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 国の統計から見た危険因子、動脈硬化性疾患の推移(シンポジウム1)2020

    • Author(s)
      藤吉 朗
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White-matter Injury In Asymptomatic Middle-aged Men2020

    • Author(s)
      Suzuki H, Fujiyoshi A, et al.
    • Organizer
      AHA Epi/Lifestyle2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lipoprotein Particle Profiles compared with Standard Lipids in the Association with Subclinical Aortic Valve Calcification in Apparently Healthy Japanese men2019

    • Author(s)
      Thien Vu, Fujiyoshi A. et al.
    • Organizer
      European Society of Cardiology Congress-2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Socioeconomic Status and Prevalence, Awareness, Treatment, Control Rates of Hypertension in Japan2019

    • Author(s)
      Fujiyoshi Akira
    • Organizer
      51th Scientific Meeting of the Korean Society of Hypertension
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動脈硬化疫学研究の国際比較:日米比較を中心に2019

    • Author(s)
      藤吉 朗
    • Organizer
      第51回日本動脈硬化学会総会・学術集会(シンポジウム)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 魚油摂取マーカーとしての血中オメガ3脂肪酸濃度2019

    • Author(s)
      藤吉 朗
    • Organizer
      第55回日本循環器病予防学会学術集会 (パネルディスカッション)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Association between intracranial subclinical vessel diseases and cognition in a community-based sample of Japanese men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)2019

    • Author(s)
      Takahiro Ito, Akira Fujiyoshi, Takayoshi Ohkubo et al.
    • Organizer
      AHA Epi/Lifestlye2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 一般住民男性における無症候性頭蓋内血管性病変と認知機能との関連 滋賀動脈硬化疫学研究SESSA2018

    • Author(s)
      伊藤 隆洋, 藤吉 朗, 大久保 孝義ほか
    • Organizer
      第54回日本循環器疾患予防学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 一般住民男性における客観的身体活動量と認知機能との関連 滋賀動脈硬化疫学研究(SESSA)2018

    • Author(s)
      澁川 武志, 藤吉 朗, 三浦 克之ほか
    • Organizer
      第54回日本循環器疾患予防学会
    • Related Report
      2018 Annual Research Report
  • [Remarks] Akira Sekikawa, MD, (University of Pittsburgh)

    • URL

      https://publichealth.pitt.edu/home/directory/akira-sekikawa

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-12-28  

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