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A community-based cohort study on the indicators of monitoring intraindividual blood glucose variability and the risk of incident diabetes mellitus

Research Project

Project/Area Number 18H03050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionKindai University (2021-2022)
Osaka University (2018-2020)

Principal Investigator

Imano Hironori  近畿大学, 医学部, 教授 (90450923)

Co-Investigator(Kenkyū-buntansha) 羽山 実奈  公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病予防健診部・健康開発, その他部局等, 医員 (10731549)
山岸 良匡  筑波大学, 医学医療系, 教授 (20375504)
丸山 広達  愛媛大学, 農学研究科, 准教授 (20627096)
服部 聡  大阪大学, 大学院医学系研究科, 教授 (50425154)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords血糖変動 / モニタリング / 糖尿病 / 地域住民 / コホート
Outline of Final Research Achievements

To investigate the relationship between intraindividual blood glucose variability and physical factors, lifestyle, and the risk of incident diabetes, we conducted blood glucose monitoring in daily life using an FGM device in three areas (Osaka Y city, Akita I town, Ibaraki C city) in the CIRCS (Circulatory Risk in Communities study) and Ibaraki K city. Non-diabetic 1,176 residents (347 men and 829 women) aged 40-69 years were epidemiologically analyzed for relations between postprandial hyperglycemia suspicion or blood glucose spikes and physical factors, lifestyle, and the risk of incident diabetes. The results revealed that blood glucose variability was associated with many physical factors and lifestyle habits, that the type, strength, and direction of those factors varied with time of day, and that they may be related to the risk of incident diabetes independently of mean blood glucose level.

Academic Significance and Societal Importance of the Research Achievements

これまで、平均血糖レベルと独立して、個人内血糖変動が糖尿病発症と関連するか否かは、検査機器の機能面・費用面・簡便性等の制約の問題があり、一般住民を対象とした疫学研究への導入が困難であったことから、明らかにされていなかった。本研究では近年開発されたFGM検査装置を用いて、4地域在住の非糖尿病者1,000人以上を対象として日常生活における血糖変動とその関連要因を明らかにし、その後の糖尿病発症との関連まで検討した世界初の研究という点で学術的意義が大きく、世界的に増加している糖尿病の予防に資する研究として社会的意義も大きい。今後さらに追跡調査を重ね、エビデンスをより強固なものにして行く必要がある。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (3 results)

All 2023 2022 2020

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Relationships of habitual daily alcohol consumption with all-day and time-specific average glucose levels among non-diabetic population samples2023

    • Author(s)
      Ishihara Maho、Imano Hironori、Muraki Isao、Yamagishi Kazumasa、Maruyama Koutatsu、Hayama-Terada Mina、Tanaka Mari、Yasuoka Mikako、Kihara Tomomi、Kiyama Masahiko、Okada Takeo、Takada Midori、Shimizu Yuji、Sobue Tomotaka、Iso Hiroyasu
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 28 Issue: 0 Pages: 20-20

    • DOI

      10.1265/ehpm.22-00215

    • ISSN
      1342-078X, 1347-4715
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 非糖尿病一般地域住民の日常生活における血糖モニタリングデータと飲酒習慣との関連2022

    • Author(s)
      石原 真穂, 今野 弘規, 村木 功, 山岸 良匡, 羽山 実奈, 丸山 広達, 田中 麻理, 木山 昌彦, 岡田 武夫, 高田 碧, 清水 悠路, 岸田 里恵, 木原 朋未, 安岡 実佳子, 磯 博康
    • Organizer
      日本公衆衛生学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 3地域住民の非糖尿病者における、男女別・時間帯別にみた血糖変動に関する検討 The Circulatory Risk in Communities Study(CIRCS)2020

    • Author(s)
      石原 真穂, 今野 弘規, 村木 功, 山岸 良匡, 丸山 広達, 羽山 実奈, 久保田 康彦, 岡田 武夫, 木山 昌彦, 磯 博康
    • Organizer
      日本循環器病予防学会
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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