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Development of approach to improve functional outcome after robot-assisted radical prostatectomy

Research Project

Project/Area Number 18H03123
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionTohoku University

Principal Investigator

ARAI Yoichi  東北大学, 医学系研究科, 名誉教授 (50193058)

Co-Investigator(Kenkyū-buntansha) 川守田 直樹  東北大学, 大学病院, 講師 (00617524)
山下 慎一  東北大学, 大学病院, 講師 (10622425)
伊藤 明宏  東北大学, 医学系研究科, 教授 (70344661)
三塚 浩二  東北大学, 医学系研究科, 准教授 (80568171)
川崎 芳英  東北大学, 大学病院, 助教 (80722256)
泉 秀明  東北大学, 医学系研究科, 非常勤講師 (80722545)
嶋田 修一  東北大学, 大学病院, 助教 (80749218)
佐藤 琢磨  東北大学, 大学病院, 助教 (80804856)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords前立腺全摘術 / 尿失禁 / 性機能 / リハビリテーション / ロボット支援
Outline of Final Research Achievements

Pelvic hemodynamics in rat was evaluated by stimulating pelvic nerve, which branched out from sacral nerve. Neuromodulation increased blood flow to bladder, prostate, and penis via stimulation of pelvic nerves.
This study enrolled patients with localized prostate cancer who underwent MRI before radical prostatectomy. Continence was evaluated using the Expanded Prostate Index Composite (EPIC) instrument before surgery and at 1, 3, 6, and 12 months after surgery. Minimal residual membranous urethral length (mRUL) was measured the distance between the lower margins of the puboperinealis and bulbospongiosus muscles in a direction parallel with the urethra on preoperative MRI. Preoperative mRUL was associated with continence after radical prostatectomy.

Academic Significance and Societal Importance of the Research Achievements

本研究にてニューロモジュレーションで骨盤内血流を増加させることができ勃起機能を改善させる可能性が示唆された。さらに、電極を改良することで海綿体神経損傷に対する新たなEDリハビリテーションの可能性を見出すことができた。
また、術前MRI画像による最小残存尿道括約筋長は術後の尿禁制回復の予測因子になり得ると考えられ、ロボット支援下前立腺全摘術の機能的アウトカムを改善させるために前立腺癌患者が治療を選択する際に最小残存尿道括約筋長が臨床決断に活用できる可能性を見出した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(37 results)

All 2021 2020 2019 2018

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 3 results,  Invited: 12 results) Book (12 results)

  • [Journal Article] Aberrant hypermethylation-mediated suppression of PYCARD is extremely frequent in prostate cancer with Gleason score >=72021

    • Author(s)
      Toshiya Miyauchi, Masahiro Takahashi, Koji Mitsuzuka, Yuriko Saiki, Teppei Okubo, Paula M. Vertino, Akiteru Goto, Yoichi Arai, Akira Horii, and Shinichi Fukushige
    • Journal Title

      Disease Markers

      Volume: 2021 Pages: 1-13

    • DOI

      10.1155/2021/8858905

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Effect of Treatment Sequence on Overall Survival for Men With Metastatic Castration-resistant Prostate Cancer: A Multicenter Retrospective Study2020

    • Author(s)
      Okita Kazutaka、Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Ishida Masanori、Kawaguchi Toshiaki、Ishidoya Shigeto、Shimoda Jiro、Sato Hiromi、Mitsuzuka Koji、Ito Akihiro、Tsuchiya Norihiko、Arai Yoichi、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      Clin Genitourin Cancer.

      Volume: 18

    • DOI

      10.1016/j.clgc.2019.09.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of tumor burden with the eligibility of upfront intensification therapy in metastatic castration‐sensitive prostate cancer: A multicenter retrospective study2020

    • Author(s)
      Hatakeyama Shingo、Narita Shintaro、Takahashi Masahiro、Sakurai Toshihiko、Kawamura Sadafumi、Hoshi Senji、Ishida Masanori、Kawaguchi Toshiaki、Ishidoya Shigeto、Shimoda Jiro、Sato Hiromi、Hamano Itsuto、Okamoto Teppei、Mitsuzuka Koji、Ito Akihiro、Tsuchiya Norihiko、Arai Yoichi、Habuchi Tomonori、Ohyama Chikara
    • Journal Title

      International Journal of Urology

      Volume: 27 Pages: 610-617

    • DOI

      10.1111/iju.14258

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 特集 排尿・排便障害-初期診療から専門的診療まで2020

    • Author(s)
      味村俊樹、荒井陽一、佐田尚宏(企画・監修)
    • Journal Title

      日本医師会雑誌

      Volume: 149 Pages: 809-875

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 巻頭言 排尿・排便障害の現状と課題2020

    • Author(s)
      荒井陽一
    • Journal Title

      日本医師会雑誌

      Volume: 149 Pages: 809-809

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 座談会 排尿障害と排便障害の診療-その類似点と相違点2020

    • Author(s)
      荒井陽一、前田耕太郎、味村俊樹、後藤百万、山西友典
    • Journal Title

      日本医師会雑誌

      Volume: 149 Pages: 813-826

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Validation and development of the CHAARTED criteria in patients with hormone-naive metastatic prostate cancer: A multi-institutional retrospective study in Japan.r2020

    • Author(s)
      Okamoto T, Hatakeyama S, Narita S, Arai Y, Habuchi T, Ohyama C
    • Journal Title

      Int J Urol

      Volume: 27(1) Pages: 90-91

    • DOI

      10.1111/iju.14136

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients2019

    • Author(s)
      Terada Naoki、Kamoto Toshiyuki、Tsukino Hiromasa、Mukai Shoichiro、Akamatsu Shusuke、Inoue Takahiro、Ogawa Osamu、Narita Shintaro、Habuchi Tomonori、et al.
    • Journal Title

      BMC Cancer

      Volume: 19 Pages: 156-156

    • DOI

      10.1186/s12885-019-5342-9

    • NAID

      120006709422

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The expression of sex steroid receptors and sex steroid-synthesizing/metabolizing enzymes in metastasized lymph nodes of prostate cancer.2019

    • Author(s)
      3.Nakamura Y, Ise K, McNamara KM, Azmahani A, Sato S, Fujishima F, Joh K, Suzuki H, Mitsuzuka K, Arai Y, Takahashi H, Sasano H.
    • Journal Title

      Hum Pathol.

      Volume: 84 Pages: 124-132

    • DOI

      10.1016/j.humpath.2018.09.011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] ロボット手術の現状と未来2020

    • Author(s)
      荒井陽一
    • Organizer
      令和元年度宮城県医師会がん対策に係わる医療従事者養成事業講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 泌尿器骨盤外科の醍醐味:考える外科医になるために2020

    • Author(s)
      荒井陽一
    • Organizer
      第72回西日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Minimal residual membranous urethral length and me urethral length can be predictive factors for poor recovery from in after radical prostatectomy.2019

    • Author(s)
      Ohara E, Kawamorita N, Saito H, Ishidoya S, Arai Y
    • Organizer
      American urological association Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ロボット支援腹腔鏡下前立腺全摘術の神経温存に役立つ組織接着用シート2019

    • Author(s)
      山下慎一、荒井陽一、伊藤明宏
    • Organizer
      第32回日本内視鏡外科学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 泌尿器骨盤外科はおもしろい:考える外科医になるために.2019

    • Author(s)
      荒井陽一
    • Organizer
      泌尿器科日常診療向上のためのウロセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Surgeon-scientistを目指して.2019

    • Author(s)
      荒井陽一
    • Organizer
      第28回日本形成外科学会基礎学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Radical prostatectomy: My favorite and a treasury of research2018

    • Author(s)
      Yoichi Arai
    • Organizer
      2018 Asan-Michinoku Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of tissue sealing sheets on erectile function following robotic-assisted laparoscopic prostatectomy: Interim results of a randomized controlled trial2018

    • Author(s)
      Shinichi Yamashita
    • Organizer
      AUA Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 前立腺癌内分泌療法の今までとこれから2018

    • Author(s)
      荒井陽一
    • Organizer
      第19回ホルモンと癌研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ロボット手術の現状と未来2018

    • Author(s)
      荒井陽一
    • Organizer
      宮城県立がんセンターセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 外科解剖は生きている:手術上達のために2018

    • Author(s)
      荒井陽一
    • Organizer
      第6回青柳手術手技研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 前立腺癌内分泌療法の今までとこれから:今さら聞けない目からウロコのエビデンス2018

    • Author(s)
      荒井陽一
    • Organizer
      第7回Prostate Cancer Innovation Symposium
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 泌尿器骨盤外科は面白い:小さなsurgeon scientistを目指そう2018

    • Author(s)
      荒井陽一
    • Organizer
      山形県泌尿器科研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 前立腺癌内分泌療法を再考する2018

    • Author(s)
      荒井陽一
    • Organizer
      前立腺シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ロボット支援腹腔鏡下前立腺全摘術後の勃起障害に対する組織接着用シートの有効性に関する無作為化比較対照試験:中間解析報告2018

    • Author(s)
      山下慎一
    • Organizer
      第106回 日本泌尿器科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ロボット支援腹腔鏡下前立腺全摘術後の勃起障害に対する組織接着用シートの有効性に関する無作為化比較対照試験:中間解析報告2018

    • Author(s)
      山下慎一
    • Organizer
      第15回 泌尿器科再建再生研究会
    • Related Report
      2018 Annual Research Report
  • [Book] Urologic Surgery Next シリーズ: No.6尿失禁・女性泌尿器科手術2020

    • Author(s)
      高橋 悟 (担当編集),荒井陽一, 土谷順彦,山本新吾 (編)
    • Total Pages
      213
    • Publisher
      メデイカルビュー社
    • Related Report
      2020 Annual Research Report
  • [Book] Prostate Cancer Frontline vol. 9 No.12020

    • Author(s)
      内藤誠二、荒井陽一、鈴木和浩、原 勲編
    • Total Pages
      16
    • Publisher
      アステラス製薬
    • Related Report
      2020 Annual Research Report
  • [Book] Hormone Therapy and Castration Resistance of Prostate Cancer2018

    • Author(s)
      Arai Y, Ogawa O (eds)
    • Total Pages
      433
    • Publisher
      Springer Japan
    • Related Report
      2018 Annual Research Report
  • [Book] Introduction. In Hormone Therapy and Castration Resistance of Prostate Cancer, ed. Y Arai and O Ogawa2018

    • Author(s)
      Arai Y, Ogawa O
    • Total Pages
      433
    • Publisher
      Springer Japan
    • Related Report
      2018 Annual Research Report
  • [Book] Therapy for Clinically Localized Prostate Cancer (Chapter 14). In Hormone Therapy and Castration Resistance of Prostate Cancer, ed. Y Arai and O Ogawa2018

    • Author(s)
      Arai Y, Mitsuzuka K
    • Total Pages
      433
    • Publisher
      Springer Japan
    • Related Report
      2018 Annual Research Report
  • [Book] Complications of Androgen Deprivation Therapy for Prostate Cancer: Metabolic Change (Chapter 17). In Hormone Therapy and Castration Resistance of Prostate Cancer, ed. Y Arai and O Ogawa2018

    • Author(s)
      Mitsuzuka K, Arai Y
    • Total Pages
      433
    • Publisher
      Springer Japan
    • Related Report
      2018 Annual Research Report
  • [Book] Androgen Receptor Splice Variant in Prostate Cancer (Chapter 29). In Hormone Therapy and Castration Resistance of Prostate Cancer, ed. Y Arai and O Ogawa2018

    • Author(s)
      Yamashita S, Arai Y
    • Total Pages
      433
    • Publisher
      Springer Japan
    • Related Report
      2018 Annual Research Report
  • [Book] 日本人の前立腺がんはホルモン療法が効きやすいのか?2018

    • Author(s)
      荒井陽一
    • Total Pages
      208
    • Publisher
      日医雑誌
    • Related Report
      2018 Annual Research Report
  • [Book] Urologic Surgery Next シリーズ: No.1 腹腔鏡手術.2018

    • Author(s)
      荒井陽一(担当編集),土谷順彦,山本新吾,高橋 悟(編)
    • Total Pages
      201
    • Publisher
      メデイカルビュー社
    • Related Report
      2018 Annual Research Report
  • [Book] Urologic Surgery Next シリーズ: No.2 ロボット支援手術.2018

    • Author(s)
      土谷順彦(担当編集)、山本新吾、高橋 悟、荒井陽一 (編)
    • Total Pages
      185
    • Publisher
      メデイカルビュー社
    • Related Report
      2018 Annual Research Report
  • [Book] Urologic Surgery Next シリーズ: No.3 エンドウロロジー.2018

    • Author(s)
      山本新吾 (担当編集)、土谷順彦、高橋 悟、荒井陽一 (編)
    • Total Pages
      168
    • Publisher
      メデイカルビュー社
    • Related Report
      2018 Annual Research Report
  • [Book] Urologic Surgery Next シリーズ: No.4 オープンサージャリー.2018

    • Author(s)
      土谷順彦(担当編集)、山本新吾、高橋 悟、荒井陽一 (編)
    • Total Pages
      207
    • Publisher
      メデイカルビュー社
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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