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Mechanisms of sweat glands adaptation to exercise training and an application for heat related desease prevention

Research Project

Project/Area Number 18H03146
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionNiigata University

Principal Investigator

Amano Tatsuro  新潟大学, 人文社会科学系, 准教授 (60734522)

Co-Investigator(Kenkyū-buntansha) 藤井 直人  筑波大学, 体育系, 助教 (00796451)
井上 芳光  大阪国際大学, 人間科学部, 教授 (70144566)
近藤 徳彦  神戸大学, 人間発達環境学研究科, 教授 (70215458)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywordsエクリン汗腺 / 熱中症 / 体温調節 / イオントフォレーシス / 経皮薬剤送達 / 運動トレーニング / 発汗 / 皮膚血管 / カリウムチャネル / マイクロニードルパッチ / 経皮ドラッグデリバリー / アドレナリン受容体 / カルシウムチャンネル / アドレナリン / アポクリン汗腺 / 暑熱順化 / ノルアドレナリン / 汗腺 / マイクロダイアリシス / カルシトニン遺伝子関連ペプチド / 神経伝達物質
Outline of Final Research Achievements

We have been investigated the underlying mechanisms of adaptative sweat production to habitual exercise training. Our results briefly indicate that noradrenergic sympathetic nerve, alpha adrenergic stimulation, and L-type voltage gated Ca2+ channels could contribute to a high sweat production in habitually trained individuals. We also demonstrated that beta-adrenergic sweating is potentiated by an exposure to heat stress in which the response mediated by the co-activation of muscarinic acetylcholine receptors. Sex difference modulates adrenergic sweating. Collectively, these results developed some of the mechanisms of a high sweat production observed in habitually trained men.

Academic Significance and Societal Importance of the Research Achievements

我が国の夏の熱中症問題を解決することは国民の健康や多くの命を守るために不可欠である.ヒトが生来有する体温調節能力のうち,発汗は体内の熱を体外に放散する強力な機構である.本研究では,運動トレーニングによって改善される発汗機能のメカニズムの解明を試みた.本研究で得られた結果は,熱中症を予防する身体機能を支える基盤の解明につながっており,将来的には得られた結果を実際の熱中症予防へ応用する試みにつながる.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (27 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (14 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 12 results,  Open Access: 4 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Remarks (1 results)

  • [Int'l Joint Research] University of Ottawa(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] オタワ大学(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Comparisons of cardiorespiratory and thermoregulatory responses to table tennis and cycling at similar perceived levels of effort2021

    • Author(s)
      Ishiguro A and Amano T
    • Journal Title

      Science and Sports

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relative contribution of α- and β-adrenergic sweating during heat exposure and the influence of sex and training status2020

    • Author(s)
      Amano T, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, and Kondo N
    • Journal Title

      Experimental Dermatology

      Volume: 29 Issue: 12 Pages: 1216-1224

    • DOI

      10.1111/exd.14208

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of L-type voltage-gated Ca2+ channel blockade on cholinergic and thermal sweating in habitually trained and untrained men2020

    • Author(s)
      Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, and Kondo N
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 319 Issue: 5 Pages: R584-R591

    • DOI

      10.1152/ajpregu.00167.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Does the iontophoretic application of bretylium tosylate modulate sweating during exercise in the heat in habitually trained and untrained men?2020

    • Author(s)
      Amano T, Sekihara S, Fujii N, Kenny GP, Inoue Y, and Kondo N
    • Journal Title

      Exp Physiol

      Volume: 105 Issue: 10 Pages: 1692-1699

    • DOI

      10.1113/ep088797

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of casein hydrolysate ingestion on thermoregulatory responses in healthy adults during exercise in heated conditions: a randomized crossover trial2020

    • Author(s)
      Sakata Y, Yoshida C, Fujiki Y, Matsunaga Y, Nakamura H, Shimizu T, Takeda Y, and Amano T
    • Journal Title

      Nutrients

      Volume: 12 Issue: 3 Pages: 867-867

    • DOI

      10.3390/nu12030867

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does α1-adrenergic receptor blockade modulate sweating during incremental exercise in young endurance-trained men?2020

    • Author(s)
      Amano T, Fujii N, Kenny GP, Inoue Y, and Kondo N
    • Journal Title

      European Journal of Applied Physiology

      Volume: 120 Issue: 5 Pages: 1123-1129

    • DOI

      10.1007/s00421-020-04351-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of isomaltulose ingestion on postexercise hydration state and heat loss responses in young men2019

    • Author(s)
      Amano T, Sugiyama Y, Okumura J, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, Kondo N, Sasagawa K, Enoki Y, and Maejima D
    • Journal Title

      Experimental Physiology

      Volume: 104 Issue: 10 Pages: 1494-1504

    • DOI

      10.1113/ep087843

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The influence of local skin temperature on the sweat glands maximum ion reabsorption rate2019

    • Author(s)
      Gerrett N, Amano T, Havenith G, Inoue Y, Kondo N
    • Journal Title

      Eur J Appl Physiol

      Volume: 119 Issue: 3 Pages: 685-695

    • DOI

      10.1007/s00421-018-04059-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of ice slushy ingestion and cold water immersion on thermoregulatory behavior2019

    • Author(s)
      Choo HC, Peiffer JJ, Lopes-Silva JP, Mesquita RN, Amano T, Kondo N, and Abbiss CR
    • Journal Title

      PloS one

      Volume: 14 Issue: 2 Pages: e0212966-e0212966

    • DOI

      10.1371/journal.pone.0212966

    • NAID

      120006599087

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of dietary nitrate supplementation on local sweating and cutaneous vascular responses during exercise in a hot environment2018

    • Author(s)
      Amano Tatsuro、Okushima Dai、Breese Brynmor C.、Bailey Stephen J.、Koga Shunsaku、Kondo Narihiko
    • Journal Title

      European Journal of Applied Physiology

      Volume: 118 Issue: 8 Pages: 1579-1588

    • DOI

      10.1007/s00421-018-3889-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cutaneous adrenergic nerve blockade attenuates sweating during incremental exercise in habitually trained men2018

    • Author(s)
      Amano T, Fujii N, Inoue Y, and Kondo N.
    • Journal Title

      Journal of Applied Physiology

      Volume: 125 Issue: 4 Pages: 1041-1050

    • DOI

      10.1152/japplphysiol.00370.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-adrenergic receptor blockade does not modify non-thermal sweating during static exercise and following muscle ischemia in habitually trained individuals2018

    • Author(s)
      Amano T, Igarashi A, Fujii N, Hiramatsu D, Inoue Y, Kondo N
    • Journal Title

      Eur J Appl Physiol

      Volume: 118 Issue: 12 Pages: 2669-2677

    • DOI

      10.1007/s00421-018-3993-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 運動時の体温調節2018

    • Author(s)
      天野達郎,Nicola Gerrett,近藤徳彦
    • Journal Title

      臨床スポーツ医学

      Volume: 35 Pages: 660-663

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 暑熱環境における身体能力のリミットコントロール2018

    • Author(s)
      天野達郎,Zachary Schlader,Toby Mundel,Nicola Gerrett,近藤徳彦
    • Journal Title

      体育の科学

      Volume: 68 Pages: 561-565

    • Related Report
      2018 Annual Research Report
  • [Presentation] 経皮ドラッグデリバリー技術を用いた運動時の発汗研究2020

    • Author(s)
      天野達郎
    • Organizer
      第34回運動と体温の研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 局所的なαアドレナリン受容体阻害は漸増負荷運動時の発汗に影響するか?2019

    • Author(s)
      天野 達郎,藤井 直人,井上 芳光,近藤 徳彦
    • Organizer
      第74回日本体力医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アドレナリン性発汗の特性:環境温度,運動トレーニング,性差の影響2019

    • Author(s)
      天野 達郎,藤井 直人,西保 岳 ,井上 芳光,近藤 徳彦
    • Organizer
      第33回運動と体温の研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 運動後のイソマルチュロース飲料摂取が体液および体温調節反応に及ぼす影響2019

    • Author(s)
      前島大輔,杉山裕紀,奥村準哉,榎康明,天野達郎
    • Organizer
      第74回日本体力医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Regulation and Adaptation of Human Sweating2019

    • Author(s)
      Tatsuro Amano
    • Organizer
      快適性とスマートテキスタイル国際シンポジウム2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Does alpha adrenergic receptor blockade modulate sweating during incremental exercise in habitually trained men?2019

    • Author(s)
      Amano T, Fujii N, Inoue Y, and Kondo N
    • Organizer
      International Conference on Environmental Ergonomics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 体温調節からみた暑熱環境下のランニングパフォーマンスと暑熱順化2019

    • Author(s)
      天野達郎
    • Organizer
      第18回陸上競技学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Cutaneous adrenergic nerve blockade attenuates sweating response during incremental exercise in habitually trained and untrained men2018

    • Author(s)
      Tatsuro Amano, Naoto Fujii, Yoshimitsu Inoue, Narihiko Kondo
    • Organizer
      Experimental Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動選手の発汗メカニズムに関する研究2018

    • Author(s)
      天野達郎
    • Organizer
      第26回日本発汗学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 運動トレーニング者の優れた発汗機能の新メカニズム:ノルアドレナリン性交感神経に着目して2018

    • Author(s)
      天野達郎,藤井直人,井上芳光,近藤徳彦
    • Organizer
      第72回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 新潟大学教育学部運動と環境生理学研究室

    • URL

      https://www.leep-niigata.com/

    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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