Central circuitries underlying sympathetic adjustments to exercise

• Project/Area Number: 18H03151
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Tottori University
• Principal Investigator: Koba Satoshi 鳥取大学, 医学部, 准教授 (40565743)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: セントラルコマンド / 光遺伝学 / 交感神経系 / 運動神経系 / 中脳 / 延髄 / 歩行 / 血圧 / 運動 / 交感神経 / 交感神経活動

Outline of Final Research Achievements

The results showed that midbrain neurons projecting the medulla, that are excited by exercise, are capable of eliciting locomotor and cardiovascular responses via sympatho-motor activation. Further, these neurons were required for fine regulation of motor coordination and autonomic cardiovascular adjustments during locomotor exercise. The study demonstrated a part of central circuitries for central command.

Academic Significance and Societal Importance of the Research Achievements

19世紀末には議論されていた運動時交感神経活性の脳メカニズムは，現在も未解明である．運動発現のために生じる脳活性(セントラルコマンド，CC)は自律神経系も制御すると考えられる．本研究では遺伝子工学を用いた先端技術を融合させたin vivo生理実験から，CCの脳内回路の一端を解明した．本成果は，古典課題「運動時交感神経活性の脳メカニズムの解明」を解決へと導くだけでなく，Exercise is medicineの根幹メカニズムの解明にも資する．

Research Products

• [Journal Article] Hypothalamic-brain stem circuits generating central command function (2021)
  • Author(s): 木場 智史、奈良井 絵美
  • Journal Title: The Autonomic Nervous System Volume: 58 Issue: 1 Pages: 101-104
  • DOI: 10.32272/ans.58.1_101
  • NAID: 130008025105
  • ISSN: 0288-9250, 2434-7035
  • Peer Reviewed
• [Journal Article] Sympathoexcitatory input from hypothalamic paraventricular nucleus neurons projecting to rostral ventrolateral medulla is enhanced after myocardial infarction (2020)
  • Author(s): Koba Satoshi、Hanai Eri、Kumada Nao、Watanabe Tatsuo
  • Journal Title: American Journal of Physiology-Heart and Circulatory Physiology Volume: 319 Issue: 6 Pages: H1197-H1207
  • DOI: 10.1152/ajpheart.00273.2020
  • Peer Reviewed
• [Journal Article] 痛みの働き (2020)
  • Author(s): 木場智史
  • Journal Title: 体育の科学 Volume: 70 Pages: 704-708
• [Journal Article] Augmented fear bradycardia in rats with heart failure. (2019)
  • Author(s): Koba S, Hisatome I, Watanabe T
  • Journal Title: The Journal of Physiological Sciences Volume: 69 Issue: 6 Pages: 875-883
  • DOI: 10.1007/s12576-019-00698-1
  • NAID: 40022093938
  • Peer Reviewed / Open Access
• [Journal Article] Angiotensin II, Oxidative Stress, and Sympathetic Nervous System Hyperactivity in Heart Failure. (2018)
  • Author(s): Koba Satoshi
  • Journal Title: Yonago Acta Med Volume: 61 Pages: 103-109
  • NAID: 130007613079
  • Peer Reviewed
• [Journal Article] Sympathoexcitation by hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla (2018)
  • Author(s): Koba Satoshi、Hanai Eri、Kumada Nao、Kataoka Naoya、Nakamura Kazuhiro、Watanabe Tatsuo
  • Journal Title: The Journal of Physiology Volume: 596 Issue: 19 Pages: 4581-4595
  • DOI: 10.1113/jp276223
  • Peer Reviewed / Open Access
• [Presentation] Sympathoexcitation and locomotion by dorsal hypothalamic neurons (2021)
  • Author(s): Emi Narai, Tatsuo Watanabe, Satoshi Koba
  • Organizer: 第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会の合同大会，ウェブ開催
• [Presentation] Sympathomotor activation by midbrain locomotor neurons is mediated through glutamate release in the rostral ventrolateral medulla (2020)
  • Author(s): Satoshi Koba, Nao Kumada, Tatsuo Watanabe
  • Organizer: Experimental Biology 2020, 米国サンディエゴ（covid-19により開催中止、抄録集に抄録掲載）
  • Int'l Joint Research
• [Presentation] ラット視床下部背側領域による歩行・循環反応の生成 (2020)
  • Author(s): 奈良井絵美，渡邊達生，木場智史
  • Organizer: 第72 回日本生理学会中国四国地方会，ウェブ開催
• [Presentation] Effect of ionotropic glutamate receptor blockade in rat RVLM on sympathomotor activation by mesencephalic locomotor neurons projecting to the RVLM (2020)
  • Author(s): Satoshi Koba, Nao Kumada, Tatsuo Watanabe
  • Organizer: 第97回日本生理学会大会
• [Presentation] Fos expression in rat MLR neurons projecting to the RVLM following the voluntary treadmill exercise (2020)
  • Author(s): Yui Yamane, Tatsuo Watanabe, Satoshi Koba
  • Organizer: 第97回日本生理学会大会
• [Presentation] Sympathetic and motor activation by midbrain neurons projecting to the ventral medulla (2019)
  • Author(s): Satoshi Koba, Nao Kumada
  • Organizer: 11th congress of the international society for autonomic neuroscience
  • Int'l Joint Research
• [Presentation] 交感神経の制御基盤：光遺伝学を用いた中枢回路の解明 (2019)
  • Author(s): 木場智史
  • Organizer: Summer Conference of Autonomic Cardiology
  • Invited
• [Presentation] セントラルコマンド機能を生成する脳幹神経と神経伝達物質 (2019)
  • Author(s): 木場智史
  • Organizer: 第74回日本体力医学会大会
  • Invited
• [Presentation] セントラルコマンド機能を生成する脳幹神経の存在 (2019)
  • Author(s): 木場智史
  • Organizer: 第72回自律神経学会総会
  • Invited
• [Presentation] 中脳から延髄への投射神経による運動性生体反応の生成 (2019)
  • Author(s): 木場智史、熊田奈桜、渡邊達生
  • Organizer: 第14回環境生理学プレコングレス、兵庫県神戸市
• [Presentation] Involvement of PVN neurons projecting to the RVLM in sympathetic dysfunction in heart failure (2019)
  • Author(s): Satoshi Koba, Eri Hanai, Nao Kumada, Tatsuo Watanabe
  • Organizer: FAOPS2019、兵庫県神戸市
  • Int'l Joint Research
• [Presentation] Is sympathoexcitation by PVN-RVLM neurons augmented in heart failure? (2019)
  • Author(s): Eri Hanai, Nao Kumada, Tatsuo Watanabe, Satoshi Koba
  • Organizer: FAOPS2019、兵庫県神戸市
  • Int'l Joint Research
• [Presentation] Sympathetic nerve response to optogeneticinhibition of PVN-RVLM neurons in anesthetized rats with heart failure (2018)
  • Author(s): Eri Hanai, Nao Kumada, Tatsuo Watanabe, Satoshi Koba
  • Organizer: Experimental Biology 2018、米国サンディエゴ市
  • Int'l Joint Research
• [Presentation] Sympathoexcitatory role for neurons projecting from the MLR to the RVLM in rats (2018)
  • Author(s): Satoshi Koba, Nao Kumada, Eri Hanai, Naoya Kataoka, Kazuhiro Nakamura, Tatsuo Watanabe
  • Organizer: Experimental Biology 2018、米国サンディエゴ市
  • Int'l Joint Research
• [Presentation] ラット中脳歩行誘発野から延髄吻側腹外側野への投射神経の光遺伝学刺激による交感神経活性 (2018)
  • Author(s): 木場智史、熊田奈桜、花井映里、渡邊達生
  • Organizer: 第73回日体力医学会大会、福井県福井市
• [Presentation] ラット中脳歩行誘発野から延髄吻側腹外側野への投射神経による交感神経調節 (2018)
  • Author(s): 熊田奈桜、木場智史、花井映里、渡邊達生
  • Organizer: 第70回日本生理学会中国四国地方会、愛媛県松山市
• [Presentation] セントラルコマンドの中枢回路：中脳から延髄への投射神経 (2018)
  • Author(s): 熊田奈桜、木場智史
  • Organizer: 第46回自律神経生理研究会、東京都新宿区
• [Remarks] リサーチマップ
  • URL: https://researchmap.jp/satoshi_koba
• [Remarks] 鳥取大学医学部 この人に注目！
  • URL: https://www.med.tottori-u.ac.jp/researchers/pickup/18016.html