| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
In this study, we found that spontaneous movement of mice promotes the transfer of leptin from the periphery to the center with the activation of orexin neurons, thereby increasing the sensitivity of leptin in the hypothalamus. On the other hand, we found that continuous spontaneous movement increased the number of neural stem cells in the hypothalamus of mice. We also found that changes in skeletal muscle gene expression due to exercise habits may change blood metabolite levels, which may have a direct effect on the brain. These suggest that exercise may have a significant effect on the plasticity of hypothalamic neurons involved in basal metabolism.
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