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Research on causality and neurobehavioral mechanisms in the association between internal desynchronization caused by rotating shift work and mental and physical health problems

Research Project

Project/Area Number 18H03175
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionThe University of Tokyo

Principal Investigator

Fumiharu Togo  東京大学, 大学院教育学研究科(教育学部), 教授 (90455486)

Co-Investigator(Kenkyū-buntansha) 石渡 貴之  立教大学, コミュニティ福祉学部, 教授 (40435235)
吉崎 貴大  東洋大学, 食環境科学部, 准教授 (50732830)
小松 泰喜  日本大学, スポーツ科学部, 教授 (80436451)
緒形 ひとみ  広島大学, 人間社会科学研究科(総), 准教授 (80455930)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords交代制勤務 / 心身の健康 / 睡眠 / 栄養 / 概日リズム / 内的脱同調 / 食行動 / 時間行動科学
Outline of Final Research Achievements

We found that morningness/eveningness or circadian rhythms were associated with habitual breakfast skipping in rotating-shift workers, and that this leads to unfavorable diet quality and may explain in part the differences in diet quality between rotating-shift workers and day-shift workers. In addition, shifts in sleep timing due to social factors were associated with the unfavorable diet quality which was identified in rotating-shift workers. Furthermore, it was suggested that these associations may involve executive and inhibitory functions, as well as neurotransmitters in the hippocampus and suprachiasmatic nucleus.

Academic Significance and Societal Importance of the Research Achievements

交代制勤務者では、夜型指向性は食の嗜好性、食事内容、睡眠の変容、抑うつレベルの増大と関連することから、夜勤への適応不全というよりも、夜勤時から日勤時への勤務(覚醒)時間帯の急激な変化にともなう内的脱同調が食事と睡眠の変容、心身の健康問題を生じうる要因である可能性がある。本研究は、その神経行動学的メカニズムの一端を明らかにした点で学術的意義がある。また、本研究の成果は、交代制勤務者の心身の健康問題の対応策の構築に対して貢献しうる点で社会的疑義がある。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (24 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (4 results)

  • [Journal Article] Interactive effects of job stressor and chronotype on depressive symptoms in day shift and rotating shift workers2022

    • Author(s)
      Togo Fumiharu、Yoshizaki Takahiro、Komatsu Taiki
    • Journal Title

      Journal of Affective Disorders Reports

      Volume: 9 Pages: 100352-100352

    • DOI

      10.1016/j.jadr.2022.100352

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Objectively measured chronotype and social jetlag are associated with habitual dietary intake in undergraduate students2021

    • Author(s)
      Yoshizaki T, Togo F.
    • Journal Title

      Nutrition Research

      Volume: 90 Pages: 36-45

    • DOI

      10.1016/j.nutres.2021.04.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 運動習慣の精神的健康への影響2021

    • Author(s)
      金鎭赫、東郷史治
    • Journal Title

      精神科

      Volume: 39 Pages: 630-636

    • Related Report
      2020 Annual Research Report
  • [Journal Article] ライフステージと時間栄養学2020

    • Author(s)
      吉﨑貴大、東郷史治
    • Journal Title

      アグリバイオ

      Volume: 4 Pages: 28-42

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 運動療法研究の気になる進歩2020

    • Author(s)
      三井悠輔、東郷史治
    • Journal Title

      精神科

      Volume: 36 Pages: 86-91

    • Related Report
      2019 Annual Research Report
  • [Journal Article] シフトワーカーの食事・栄養2020

    • Author(s)
      吉崎貴大、東郷史治
    • Journal Title

      臨床栄養

      Volume: 136 Pages: 327-333

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A practical guide to analyzing time-varying association between physical activity and affect using multilevel modeling2018

    • Author(s)
      Kim, J., D. Marcusson-Clavertz, F. Togo, H. Park
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: 2018 Pages: 8652034-8652034

    • DOI

      10.1155/2018/8652034

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Computational tools and techniques for early diagnosis and screening of geriatric diseases2018

    • Author(s)
      Park, H., F. Togo, M. Miyashita
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: 2018 Pages: 7830584-7830584

    • DOI

      10.1155/2018/7830584

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 青少年の社会的時差ぼけと不安・抑うつに関するシステマティックレビュー2023

    • Author(s)
      鈴木太朗、東郷史治
    • Organizer
      第15回日本不安症学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Association between robustness of 24-hour pattern of sleep/wake, energy intake, and interstitial glucose level over seven days among young adults2022

    • Author(s)
      Yoshizaki, T., K. Konishi, F. Togo
    • Organizer
      22nd IUNS-ICN International Congress of Nutrition
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 思春期の子どもにおける睡眠時間とSNS使用時間が抑うつに与える影響の検討~Isotemporal Substitution Modelによる置き換え効果~2022

    • Author(s)
      本多正理佳、松隈誠矢、東郷史治
    • Organizer
      日本睡眠学会第47回定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 不眠を持つ高齢者での身体活動量とうつの関係2020

    • Author(s)
      三井悠輔、武市理、小松泰喜、東郷史治
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Irregular behavioral patterns and mental/physical health problems in aged society2019

    • Author(s)
      Togo, F.
    • Organizer
      The 1st Joint Scientific Meeting on Physical Activity and Exercise Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 眠る2019

    • Author(s)
      東郷史治
    • Organizer
      発達と保育の本質の探究~人の育ちとそれを支える営みを見つめて~
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Association of emotional and behavioral difficulties with insomnia symptoms, sleep duration, and sleep timing among children2019

    • Author(s)
      Sabouri, S., Y. Ojio, A. Kishi, F. Togo
    • Organizer
      日本睡眠学会第44回定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of short span of sleep deprivation on brain monoaminergic neurotransmitters, physical indices and behavior in rats2019

    • Author(s)
      Matsunaga, D., M. Sato, F. Togo, T. Ishiwata
    • Organizer
      Federation of European Neuroscience Societies Regional Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢社会が抱える生活リズムの変調と心身の健康問題2019

    • Author(s)
      東郷史治
    • Organizer
      第1回身体活動・運動科学に関する日中韓共同研究交流会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 交代勤務モデルラットの生理指標、情動行動、脳内神経伝達物質の比較2019

    • Author(s)
      佐藤美穂、松長大祐、東郷史治、石渡貴之
    • Organizer
      第172回体力医学会関東地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Circadian clock and physical activity rhythms and frailty in the elderly: the abnormalities in the circadian/diurnal rhythm2018

    • Author(s)
      Togo, F.
    • Organizer
      International Symposium on Online-to-Offline based Exercise and Physical Activity Intervention for Fighting Frailty
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大学生における夜間勤務のアルバイト、朝型夜型指向性と食行動との関連2018

    • Author(s)
      吉崎貴大、東郷史治
    • Organizer
      第65回日本栄養改善学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Book] "働き盛りの健康維持増進に対する時間栄養学の可能性" In: 柴田重信編, 時間栄養学. 時計遺伝子、体内時計、食生活をつなぐ2020

    • Author(s)
      吉﨑貴大、東郷史治
    • Total Pages
      7
    • Publisher
      化学同人
    • ISBN
      9784759820362
    • Related Report
      2020 Annual Research Report
  • [Book] "睡眠のメカニズムと認知機能" In: 金森雅夫編, 認知症plus予防教室2020

    • Author(s)
      東郷史治
    • Total Pages
      7
    • Publisher
      日本看護協会出版会
    • ISBN
      9784818022485
    • Related Report
      2019 Annual Research Report
  • [Book] "子どもと関わる人の睡眠" In: 秋田喜代美監修, 乳幼児の発達と保育 食べる・眠る・遊ぶ・繋がる2019

    • Author(s)
      東郷史治
    • Total Pages
      11
    • Publisher
      朝倉書店
    • ISBN
      9784254650082
    • Related Report
      2019 Annual Research Report
  • [Book] "Chronic Fatigue Syndrome and Fibromyalgia". In: Savard J and Ouellet M-C, (Eds). Handbook of Sleep Disorders in Medical Conditions2019

    • Author(s)
      Togo, F., A. Kishi, B. H. Natelson
    • Total Pages
      19
    • Publisher
      Elsevier
    • ISBN
      9780128130148
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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