Increased expression of PGC-1alpha in skeletal muscle suppresses the development of atherosclerosis
| Project/Area Number |
18H03181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | University of Shizuoka |
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Principal Investigator |
MIURA Shinji 静岡県立大学, 食品栄養科学部, 教授 (10342932)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 動脈硬化 / PGC-1α / FOXO-1 / 運動トレーニング / エネルギー制限 / マイオカイン / FOXO1 / VCAM1 / 骨格筋 / BAIBA / VCAM-1 / MCP-1 / 血管内皮細胞 / 単球 |
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| Outline of Final Research Achievements |
Endurance exercise training and calorie restriction suppress the development of atherosclerosis. Considering that characteristic changes of skeletal muscle are involved in this mechanism, we focused on the transcription factors PGC-1α and FOXO-1 that cause the changes of muscles due to exercise and energy restriction. In this study, we focused on skeletal muscle-specific PGC-1α or FOXO-1 overexpression on the progression of atherosclerosis was investigated. As a result, overexpression of skeletal muscle-specific PGC-1α or FOXO-1 suppresses the progression of atherosclerosis. The physiology of bioactive substances secreted from skeletal muscle, such as β-aminoisobutyric acid and Irisin, might be involved in the suppression.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、持久運動トレーニングとエネルギー制限による動脈硬化進展抑制機序の一端を、PGC-1αやFOXO-1といった骨格筋機能に着目して明らかにした。本研究で得られた成果により、骨格筋から分泌される生理活性物質（マイオカイン）に着目した動脈硬化を予防するためのバイオマーカー開発や、マイオカインを豊富に含む食品を摂取することによる動脈硬化性疾患の予防法開発に発展する可能性がある。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Skeletal muscle-specific PGC-1α overexpression suppresses atherosclerosis in apolipoprotein E-knockout mice.2019
Author(s)
Shimba, Y., Togawa, H., Senoo, N., Ikeda, M., Miyoshi, N., Morita, A., and Miura, S.
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Journal Title
Sci Rep
Volume: 9
Pages: 4077-4077
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Skeletal Muscle-specific PGC-1α Overexpression Prevents Atherosclerosis in Apolipoprotein E-Knockout Mice.2018
Author(s)
Shimba, Y., Togawa, H., Senoo, N., Ikeda, M., Miyoshi, N., Morita, A., and Miura, S.
Organizer
18th International Symposium on Atherosclerosis
Related Report
Int'l Joint Research
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