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Prevention of diabetes mellitus and Alzheimer dementia via improvement of low interstitial pH by food constituent

Research Project

Project/Area Number 18H03182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionRitsumeikan University

Principal Investigator

Marunaka Yoshinori  立命館大学, 総合科学技術研究機構, 教授 (00127036)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords糖尿病 / アルツハイマー型認知症 / 間質液pH / アミロイドベータ / インスリン抵抗性 / 間質液 / pH / 食品
Outline of Final Research Achievements

The Alzheimer's dementia onset risk is higher in diabetic persons (DM) than non-diabetic persons, but the cause is unclear. Hypothesis: 1) A decrease in the interstitial fluid liquid pH in DM elevates the activity and expression of Aβ-producing enzymes, β and γ secretases, and diminishes Aβ-degrading enzyme, neprilysin, leading to Aβ accumulations in the brain of DM. 2) A weak acid, carboxylic acid, -containing food intake prevents elevation of blood sugar level and insulin resistance by improving the interstitial fluid pH. Purpose: To clarify the hypothesis mentioned above and choose the food improving the interstitial fluid pH. Result: A weak acid, carboxylic acid, -containing food intake elevated the interstitial fluid pH (improvement) and decreased (improved) accummulation of theAβ in the brain of DM.

Academic Significance and Societal Importance of the Research Achievements

「酸カルボン酸含有食品成分摂取により、間質液pH上昇(改善)がみられ、かつアミロイドベータ蓄積量の低下(改善)がみられ」という本研究の成果は、糖尿病患者におけるインスリン抵抗性発症予防および糖尿病患者で高発するアルツハイマー型認知症発症予防を行うことができる可能性を示している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (70 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (11 results) Journal Article (34 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 33 results,  Open Access: 20 results) Presentation (23 results) (of which Int'l Joint Research: 14 results,  Invited: 11 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] National Institute of Health(イタリア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Jiangsu University/University of Macau/Zhejiang University(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National Institute of Health/Universita Politecnica delle Marche/University of Naples Federico II(イタリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] H. Lee Moffitt Cancer Center Res Inst/Medical College of Wisconsin/University of Massachusetts(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of New South Wales(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Bulgarian Academy of Sciences(ブルガリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Jiangsu University/University of Macau(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] National Institute of Health/Regina Elena Cancer Institute(イタリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] H. Lee Moffitt Cancer Center & Res Inst(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Academy of Sciences of Uzbekistan(ウズベキスタン)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance.2021

    • Author(s)
      MARUNAKA Y
    • Journal Title

      Biochem Soc Trans

      Volume: - Issue: 2 Pages: 715-726

    • DOI

      10.1042/bst20200667

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers2021

    • Author(s)
      Shiozaki Atsushi、Marunaka Yoshinori、Otsuji Eigo
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 616933-616933

    • DOI

      10.3389/fcell.2021.616933

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma membrane anchored nanosensor for quantifying endogenous production of H2O2 in living cells2021

    • Author(s)
      Hosogi Shigekuni、Marunaka Yoshinori、Ashihara Eishi、Yamada Tadaaki、Sumino Ayumi、Tanaka Hideo、Puppulin Leonardo
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 179 Pages: 113077-113077

    • DOI

      10.1016/j.bios.2021.113077

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of Xenin25 on spontaneous circular muscle contractions of rat distal colon in vitro2021

    • Author(s)
      Kuwahara Yuko、Kato Ikuo、Inui Toshio、Marunaka Yoshinori、Kuwahara Atsukazu
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 4 Pages: 1-14

    • DOI

      10.14814/phy2.14752

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system2020

    • Author(s)
      KUWAHARA Atsukazu、MATSUDA Kyoko、KUWAHARA Yuko、ASANO Shinji、INUI Toshio、MARUNAKA Yoshinori
    • Journal Title

      Biomedical Research

      Volume: 41 Issue: 5 Pages: 199-216

    • DOI

      10.2220/biomedres.41.199

    • NAID

      130007927037

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2020-10-16
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Acidic Microenvironment: Is It a Phenotype of All Cancers? A Focus on Multiple Myeloma and Some Analogies with Diabetes Mellitus2020

    • Author(s)
      Fais S, MARUNAKA Y
    • Journal Title

      Cancers

      Volume: 12 Issue: 11 Pages: 3226-3226

    • DOI

      10.3390/cancers12113226

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular Cl- Regulation of Ciliary Beating in Ciliated Human Nasal Epithelial Cells: Frequency and Distance of Ciliary Beating Observed by High-Speed Video Microscopy2020

    • Author(s)
      Yasuda M, Inui TA, Hirano S, Asano S, Okazaki T, Inui T, MARUNAKA Y, Nakahari T
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 11 Pages: 4052-4052

    • DOI

      10.3390/ijms21114052

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interactive Actions of Aldosterone and Insulin on Epithelial Na+ Channel Trafficking2020

    • Author(s)
      Marunaka R, MARUNAKA Y.
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 10 Pages: 3407-3407

    • DOI

      10.3390/ijms21103407

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Standard medical nutrition therapy of 25kcal/kg ideal bodyweight/day often does not reach even resting energy expenditure for patients with type 2 diabetes2020

    • Author(s)
      Fukuda T, Tanaka M, Yamazaki M, MARUNAKA Y, Fukui M
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 11 Issue: 3 Pages: 626-632

    • DOI

      10.1111/jdi.13167

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma.2020

    • Author(s)
      Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
    • Journal Title

      Ann Surg Oncol.

      Volume: ー Issue: 9 Pages: 3218-3230

    • DOI

      10.1245/s10434-020-08368-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Refining transfer set in calibration transfer of near infrared spectra by backward refinement of samples2020

    • Author(s)
      Zheng K, Feng T, Zhang W, Huang X, Li Z, Zhang D, Shi J, MARUNAKA Y, Zou X
    • Journal Title

      Analytical Methods

      Volume: 12 Issue: 11 Pages: 1495-1503

    • DOI

      10.1039/d0ay00085j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Body fluid pH balance in metabolic health and possible benefits of dietary alkaline foods2020

    • Author(s)
      Aoi W, Zou X, Xiao J, MARUNAKA Y
    • Journal Title

      eFood

      Volume: 1 Issue: 1 Pages: 12-23

    • DOI

      10.2991/efood.k.190924.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The algal polysaccharide ulvan suppresses growth of hepatoma cells2020

    • Author(s)
      Zhao C, Lin G, Wu D, Liu D, You L, Hogger P, Simal-Gandara J, Wang M, da Costa JGM, MARUNAKA Y, Daglia M, Khan H, Filosa R, Wang S, Xiao J
    • Journal Title

      Food Frontiers

      Volume: 1 Issue: 1 Pages: 83-101

    • DOI

      10.1002/fft2.13

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Food intake targeting and improving acidity in diabetes and cancer2020

    • Author(s)
      MARUNAKA Y, Niisato N, Zou X, Xiao J, Nakahari T
    • Journal Title

      Food Frontiers

      Volume: 1 Issue: 1 Pages: 9-12

    • DOI

      10.1002/fft2.5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Airway ciliary beating affected by the Pcp4 dose-dependent [Ca2+]i in Down syndrome mice, Ts1Rhr2020

    • Author(s)
      Kogiso H, Raveau M, Yamakawa K, Saito D, Ikeuchi Y, Okazaki T, Asano S, Inui T, MARUNAKA Y, Nakahari T
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 6 Pages: 1947-1947

    • DOI

      10.3390/ijms21061947

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Food Frontiers: An academically sponsored new journal2020

    • Author(s)
      L Wang, J Simal‐Gandara, M Du, B Lu, JL Quiles, ZY Chen, B Hennig, M Wang, H Xiao, J Arcot, T Yue, B Zheng, X Zou, Y MAMRUNAKA, et al.
    • Journal Title

      Food Frontiers

      Volume: 1 Issue: 1 Pages: 3-5

    • DOI

      10.1002/fft2.8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 細胞内 Cl-による細胞機能調節と疾患2020

    • Author(s)
      丸中良典
    • Journal Title

      腎と透析:特集 Cl-:電解質クイーン

      Volume: 88 Pages: 419-422

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Ciliary beating amplitude controlled by intracellular Cl- and a high rate of CO2 production in ciliated human nasal epithelial cells2019

    • Author(s)
      Inui TA, Murakami K, Yasuda M, Hirano S, Ikeuchi Y, Kogiso H, Hosogi S, Inui T, MARUNAKA Y, Nakahari T
    • Journal Title

      Pflugers Archiv - European Journal of Physiology

      Volume: 471 Issue: 8 Pages: 1127-1142

    • DOI

      10.1007/s00424-019-02280-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells.2019

    • Author(s)
      Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
    • Journal Title

      Int J Oncol.

      Volume: 55 Pages: 905-914

    • DOI

      10.3892/ijo.2019.4853

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma.2019

    • Author(s)
      Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
    • Journal Title

      Am J Pathol.

      Volume: 189 Issue: 10 Pages: 1973-1985

    • DOI

      10.1016/j.ajpath.2019.06.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] pH balance and lactic acid increase in the vitreous body of diabetes mellitus patients2019

    • Author(s)
      Mieno H, MARUNAKA Y, Inaba T, Kojima K, Yoneda K, Nagata K, Sotozono C
    • Journal Title

      Experimental Eye Research

      Volume: 188 Pages: 107789-107789

    • DOI

      10.1016/j.exer.2019.107789

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The expression and role of TRPV2 in esophageal squamous cell carcinoma.2019

    • Author(s)
      Kudou M, Shiozaki A, Yamazato Y, Katsurahara K, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 16055-16055

    • DOI

      10.1038/s41598-019-52227-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhancement of ciliary beat amplitude by carbocisteine in ciliated human nasal epithelial cells2019

    • Author(s)
      Inui Taka‐aki、Yasuda Makoto、Hirano Shigeru、Ikeuchi Yukiko、Kogiso Haruka、Inui Toshio、Marunaka Yoshinori、Nakahari Takashi
    • Journal Title

      The Laryngoscope

      Volume: - Issue: 5

    • DOI

      10.1002/lary.28185

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell Volume-Activated and -Correlated Anion Channels in Mammalian Cells: Their Biophysical, Molecular and Pharmacological Properties.2019

    • Author(s)
      Y. Okada, T. Okada, K.S. Numata, M.R. Islam, Y.A. Akatsuka, T. Numata, M. Kubo, T. Shimizu, R.S. Kurbannazarova, Y. Marunaka, and R.Z. Sabirov
    • Journal Title

      Pharmacological Reviews

      Volume: 71 Issue: 1 Pages: 49-88

    • DOI

      10.1124/pr.118.015917

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeting acidity in cancer and diabetes2019

    • Author(s)
      Gillies RJ, Pilot C, MARUNAKA Y, Fais S
    • Journal Title

      Biochim Biophys Acta Rev Cancer

      Volume: 1871 Issue: 2 Pages: 273-280

    • DOI

      10.1016/j.bbcan.2019.01.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl-]i in mouse airway cilia2019

    • Author(s)
      Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Matsumura H, Inui T, MARUNAKA Y, Nakahari T.
    • Journal Title

      Pflugers Arch

      Volume: 471 Issue: 2 Pages: 365-380

    • DOI

      10.1007/s00424-018-2212-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Causes, consequences, and therapy of tumors acidosis2019

    • Author(s)
      Pillai SR, Damaghi M, Marunaka Y, Spugnini EP, Fais S, Gillies RJ.
    • Journal Title

      Cancer Metastasis Rev

      Volume: 印刷中 Issue: 1-2 Pages: 205-222

    • DOI

      10.1007/s10555-019-09792-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Xenin-25 induces anion secretion by activating non-cholinergic secretomotor neurons in the rat ileum2019

    • Author(s)
      Kuwahara A, Kuwahara Y, Kato I, Kawaguchi K, Harata D, Asano S, Inui T, Marunaka Y.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 印刷中 Issue: 6 Pages: G785-G796

    • DOI

      10.1152/ajpgi.00333.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH2018

    • Author(s)
      MARUNAKA Y
    • Journal Title

      Int J Mol Sci

      Volume: 19 Issue: 10 Pages: 3244-3244

    • DOI

      10.3390/ijms19103244

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [Cl?]i Decrease in Ciliated Human Nasal Epithelial Cells2018

    • Author(s)
      Inui Taka-aki、Yasuda Makoto、Hirano Shigeru、Ikeuchi Yukiko、Kogiso Haruka、Inui Toshio、Marunaka Yoshinori、Nakahari Takashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 12 Pages: 3754-3754

    • DOI

      10.3390/ijms19123754

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito2018

    • Author(s)
      Hosogi S, Ohsawa M, Kato I, Kuwahara A, Inui T, Inui A,MARUNAKA Y
    • Journal Title

      Front Nutr

      Volume: 5 Pages: 112-112

    • DOI

      10.3389/fnut.2018.00112

    • URL

      https://pure.teikyo.jp/en/publications/25c7d5e7-6782-45bd-a7d3-4e6295c7acb4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spontaneous oscillation of the ciliary beat frequency regulated by release of Ca2+ from intracellular stores in mouse nasal epithelia2018

    • Author(s)
      Kuremoto Toshihiro、Kogiso Haruka、Yasuda Makoto、Inui Taka-aki、Murakami Kentaro、Hirano Shigeru、Ikeuchi Yukiko、Hosogi Shigekuni、Inui Toshio、Marunaka Yoshinori、Nakahari Takashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 507 Issue: 1-4 Pages: 211-216

    • DOI

      10.1016/j.bbrc.2018.11.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement.2018

    • Author(s)
      Leonardo Puppulin, Shigekuni Hosogi, Hongxin Sun, Kazuhiko Matsuo, Toshio Inui, Yasuaki Kumamoto, Toshinobu Suzaki, Hideo Tanaka and Yoshinori Marunaka
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 5278-5278

    • DOI

      10.1038/s41467-018-07726-5

    • NAID

      120006549200

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer2018

    • Author(s)
      Shiozaki Atsushi、Ariyoshi Yosuke、Iitaka Daisuke、Kosuga Toshiyuki、Shimizu Hiroki、Kudou Michihiro、Konishi Tomoki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Ichikawa Daisuke、Otsuji Eigo
    • Journal Title

      Gastric Cancer

      Volume: 22 Issue: 3 Pages: 473-485

    • DOI

      10.1007/s10120-018-0874-2

    • NAID

      40021884050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Stimulatory mechanisms of ciliary beating movement by a herbal medicine, Sei-hai-to (TJ-90; Qing Fei Tang)2020

    • Author(s)
      MARUNAKA Y, Nakahari T
    • Organizer
      4th International Symposium on Phytochemicals in Medicine and Food
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gold-nanostructure-based pH measurement in highly localized cell surface areas2020

    • Author(s)
      MARUNAKA Y, Puppulin L
    • Organizer
      Vebleo Webinar on Nanomedicine, Nanomaterials and Nanotechnology in “Science, Engineering and Technology”
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Building-up the primary culture system for ependymal ciliary cells from newborn mice2020

    • Author(s)
      Namoto Y, Ishii Y, Okazaki T, Asano S, MARUNAKA Y, Nakahari T
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Activation of airway ciliary beating by an [Ca2+]i increased via nifedipine-sensitive Ca2+ channels stimulated by amboxol2020

    • Author(s)
      Saito D, Kawaguchi K, Asano S, MARUNAKA Y, Nakahari T
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Secretory reflex pathway of short chain fatty acids in the rat distal colon2020

    • Author(s)
      Harata D, Asano S, Kuwahara A, Kuwahara Y, Kato I, Inui T, MARUNAKA Y
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Surface enhanced Raman spectroscopy probe for nanometer-scale measurement of pH and hydrogen peroxides on the outer membrane of cells2020

    • Author(s)
      Puppulin L, Hosogi S, Tanaka H, Kumamoto Y, Ashihara E, MARUANKA Y
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Non-invasive sample measurement derived from live tissue by Raman spectroscopic microscopy2020

    • Author(s)
      Akaji S, MARUNAKA Y
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Regulation of body fluid and electrolytes: Physiological significance of interstitial fluid2020

    • Author(s)
      MARUANKA Y
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Improving action of Ninji’yoeito on the syndrome of diabetes mellitus2019

    • Author(s)
      MARUNAKA Y
    • Organizer
      62th Annual Meeting of the Japan Diabetes Society
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Improving actions of natural foods and Ninjin’yoeito (a herbal medicine) on diabetes mellitus symptoms via improvement of interstitial fluid pH2019

    • Author(s)
      MARUNAKA Y
    • Organizer
      International Conference on Natural Toxicology and Pharmacology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Actions of flavonoids and natural compounds on ion environments: Its physiological roles2019

    • Author(s)
      MARUNAKA Y
    • Organizer
      International Workshop on Intelligent Detection of Food and Safety
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Involvement of EP receptors in the regulation of Short circuit current by prostaglandins in A6 cells2019

    • Author(s)
      Sun H, MARUNAKA Y, Asano S
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Secretory reflex pathway of Xenin-25 in the rat ileum2019

    • Author(s)
      Kuwahara A, Kuwahara Y, Kato I, Inui T, MARUNAKA Y
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Secretory reflex pathway of SCFA in the rat distal colon2019

    • Author(s)
      Harata D, Asano S, Kuwahara A, Inui T, MARUNAKA Y
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neurogenic relaxation of Xenin on spontaneous circular muscle contractions in rat distal colon2019

    • Author(s)
      Kuwahara Y, Kato I, Kuwahara A, MARUNAKA Y
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aldosterone action on epithelial Na+ channel trafficking under the insulin-stimulated condition2019

    • Author(s)
      Marunaka R, MARUNAKA Y
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of the frequency of airway ciliary beating by PDE1 activation in Down syndrome mouse2019

    • Author(s)
      Kogiso H, Ikeuchi Y, Tanaka S, Hosogi S, Shimamoto C, Raveau M, Yamakawa K, Nakahari T, Asano S, MARUNAKA Y
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Airway ciliary beating activated by enhanced Ca2+ signal in Hochuekki- to (TJ-41) treated mice2019

    • Author(s)
      Ikeuchi Y, Kogiso H, Tanaka S, Hosogi S, Nakahari T, Asano S, MARUNAKA Y
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Highly localized pH sensing on the outer membrane of cells using surface enhanced Raman spectroscopy2019

    • Author(s)
      Puppulin L, Hosogi S, Tanaka H, MARUNAKA Y
    • Organizer
      The 9th Congress of Federation of Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improvement of blood glucose level in diabetic rats by intake of citrate2018

    • Author(s)
      Hino K. Ebisu G, Hosogi S, MARUNAKA Y
    • Organizer
      The 7th Asian Congress of Diabetes: The rise of nutrition and diabetes in Asia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epithelial Na+ channel (ENaC) trafficking process between the intracellular space and the apical membrane using mathematical analysis with a four-state model2018

    • Author(s)
      MARUNAKA Y
    • Organizer
      The 40th Annual Meeting of The Membrane Society of Japan
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Effects of Ninjin'yoeito on insulin resistance via improvement of the interstitial fluid pH Seminar on Possibility of the Chinese medicine in the super aged society2018

    • Author(s)
      MARUNAKA Y
    • Organizer
      The 60th Annual Meeting of Japan Geriatircs Society
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Roles of ion circumstances in bodily and cellular functions: Physiological meanings of interstitial fluid pH and action of food on the interstitial fluid pH2018

    • Author(s)
      MARUNAKA Y
    • Organizer
      The 3rd International Symposium on Phytochemicals in Medicine and Food
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Encyclopedia of Respiratory Medicine2020

    • Author(s)
      Niisato N, MARUNAKA Y
    • Publisher
      Elsevier
    • ISBN
      9780123708793
    • Related Report
      2019 Annual Research Report
  • [Remarks] 丸中良典 研究室

    • URL

      https://marunaka-y.com/

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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