Kidney-mediated aging process

• Project/Area Number: 18H03191
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kagawa University
• Principal Investigator: Nishiyama Akira 香川大学, 医学部, 教授 (10325334)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 生体適応能力 / 生体防御反応 / 老化 / 腎臓病 / 異化反応 / カタボリズム（異化） / 腎機能 / 生体老化 / 体液保持 / サルコペニア / 健康長寿 / カタボリズム / 代謝異常 / 尿素 / 個体老化 / 腎臓 / 生活習慣病

Outline of Final Research Achievements

The purpose of this study was to elucidate the pathophysiology of the deterioration of renal function, which directly affects the metabolism of organs and causes individual aging. The study revealed that in 5/6 nephrectomized rats with chronic kidney disease, which causes polyuria due to reduced renal concentrating ability, or in rats with liver failure due to administration of diethylnitrosamine, reabsorption of water by the kidneys is necessary to maintain body fluid, and that urea is produced and accumulated in the kidneys through catabolism, and that the The metabolic derangement caused by the breakdown of urea production and accumulation in the kidneys leads to hypertension via functional changes in the skin.
If we can clarify the whole picture of this mechanism and develop a method to control it in the future, it is assumed that it will be possible to control physical condition in humans.

Academic Significance and Societal Importance of the Research Achievements

生体は環境の変化やストレスに適応する能力を持つが、徐々にその力は減衰し、老いとともに様々な病気が発症する。しかし、これまでの研究すべてが機能低下の「原因・要因」に着目するものばかりであり、個体の機能低下を防ぐための生体の「環境適応能力（防御反応）」に着目したものが皆無であったことが、根本的な解決が見つからない最大の問題であると考えられる。本基盤研究をきっかけとし、「夏眠様反応」という生体防御機構の全容が解明されれば、全く新しい学術領域の創出となり、QOL の向上や健康増進プロモーション、ならびに疾患横断的な治療法開発のブレイクスルーにつながるものであると考える。

Research Products

• [Int'l Joint Research] Hebei Medical University(中国)
• [Int'l Joint Research] University of California(米国)
• [Int'l Joint Research] Duke-NUS(シンガポール)
• [Int'l Joint Research] Duke-NUS(シンガポール)
• [Int'l Joint Research] University of California Merced(米国)
• [Int'l Joint Research] Zhejiang University School of Medicine(中国)
• [Int'l Joint Research] DUKE-NUS(シンガポール)
• [Journal Article] New Concept of Onco-Hypertension and Future Perspectives (2021)
  • Author(s): Kidoguchi Satoshi、Sugano Naoki、Tokudome Gorou、Yokoo Takashi、Yano Yuichiro、Hatake Kiyohiko、Nishiyama Akira
  • Journal Title: Hypertension Volume: 77 Issue: 1 Pages: 16-27
  • DOI: 10.1161/hypertensionaha.120.16044
  • Peer Reviewed
• [Journal Article] Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure (2021)
  • Author(s): Kovarik Johannes J.、Morisawa Norihiko、Wild Johannes、Marton Adriana、Takase‐Minegishi Kaoru、Minegishi Shintaro、Daub Steffen、Sands Jeff M.、Klein Janet D.、Bailey James L.、Kovalik Jean‐Paul、Rauh Manfred、Karbach Susanne、Hilgers Karl F.、Luft Friedrich、Nishiyama Akira、Nakano Daisuke、Kitada Kento、Titze Jens
  • Journal Title: Acta Physiologica Volume: 00 Issue: 1
  • DOI: 10.1111/apha.13629
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardioprotective Effects of a Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, in Dahl Salt-Sensitive Hypertensive Rats (2021)
  • Author(s): Rahman Asadur、Sawano Tatsuya、Sen Anupoma、Hossain Akram、Jahan Nourin、Kobara Hideki、Masaki Tsutomu、Kosaka Shinji、Kitada Kento、Nakano Daisuke、Imamura Takeshi、Ohsaki Hiroyuki、Nishiyama Akira
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 4 Pages: 2069-2069
  • DOI: 10.3390/ijms22042069
  • Peer Reviewed / Open Access
• [Journal Article] Sodium/glucose cotransporter 2 and renoprotection: From the perspective of energy regulation and water conservation. (2021)
  • Author(s): Kento Kitada, Satoshi Kidoguchi, Daisuke Nakano, Akira Nishiyama.
  • Journal Title: Journal of Pharmacological Sciences Volume: 147 Issue: 3 Pages: 245-250
  • DOI: 10.1016/j.jphs.2021.07.006
  • Peer Reviewed / Open Access
• [Journal Article] Protease-Activated Receptor 1 Contributes to Microcirculation Failure and Tubular Damage in Renal Ischemia-Reperfusion Injury in Mice (2021)
  • Author(s): Guan Yu、Nakano Daisuke、Li Lei、Zheng Haofeng、Nishiyama Akira、Tian Ye、Zhang Lei
  • Journal Title: BioMed Research International Volume: 2021 Issue: 1 Pages: 1-8
  • DOI: 10.1155/2021/6665714
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H (2020)
  • Author(s): Shibayama,Y., Takahashi, K., Yamaguchi, H., Yasuda, J., Yamazaki, D., Rahman, A., Fujimori, T., Fujisawa, Y., Takai, S., Furukawa, T., Nakagawa, T., Ohsaki, H., Kobara, H., Wong, J.H., Masaki, T., Yuzawa, Y., Kiyomoto, H., Yachida, S., Fujimoto, A., Nishiyama, A.
  • Journal Title: Communications Biology Volume: 3 Issue: 1 Pages: 724-724
  • DOI: 10.1038/s42003-020-01434-x
  • NAID: 130008001357
  • Peer Reviewed / Open Access
• [Journal Article] Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice (2020)
  • Author(s): Li Lei、Nakano Daisuke、Zhang Anqi、Kittikulsuth Wararat、Morisawa Norihiko、Ohsaki Hiroyuki、Suzuki Norio、Yamamoto Masayuki、Nishiyama Akira
  • Journal Title: Journal of Pharmacological Sciences Volume: 144 Issue: 4 Pages: 229-236
  • DOI: 10.1016/j.jphs.2020.09.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation (2020)
  • Author(s): Marton Adriana、Kaneko Tatsuroh、Kovalik Jean-Paul、Yasui Atsutaka、Nishiyama Akira、Kitada Kento、Titze Jens
  • Journal Title: Nature Reviews Nephrology Volume: 17 Issue: 1 Pages: 65-77
  • DOI: 10.1038/s41581-020-00350-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antiproliferative effects of monoclonal antibodies against (pro)renin receptor in pancreatic ductal adenocarcinoma (2020)
  • Author(s): Asadur Rahman , Makoto Matsuyama , Akio Ebihara , Yuki Shibayama , Arif Ul Hasan , Hironori Nakagami , Fumiaki Suzuki , Jiao Sun , Tomoe Kobayashi , Hiroki Hayashi , Daisuke Nakano , Hideki Kobara , Tsutomu Masaki , Akira Nishiyama
  • Journal Title: Molecular Cancer Therapeutics Volume: 19 Issue: 9 Pages: 1844-1845
  • DOI: 10.1158/1535-7163.mct-19-0228
  • NAID: 130007811853
  • Peer Reviewed
• [Journal Article] Esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker (MRB) in hypertension and chronic kidney disease (2020)
  • Author(s): Wan Ningning、Rahman Asadur、Nishiyama Akira
  • Journal Title: Journal of Human Hypertension Volume: 35 Issue: 2 Pages: 148-156
  • DOI: 10.1038/s41371-020-0377-6
  • Peer Reviewed
• [Journal Article] Partial Body Mass Recovery After Caloric Restriction Abolishes Improved Glucose Tolerance in Obese, Insulin Resistant Rats (2020)
  • Author(s): Cornejo Manuel A.、Nguyen Julie、Cazares Joshua、Escobedo Benny、Nishiyama Akira、Nakano Daisuke、Ortiz Rudy M.
  • Journal Title: Frontiers in Endocrinology Volume: 11 Pages: 363-363
  • DOI: 10.3389/fendo.2020.00363
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4?dependent pathway and limits sensitivity to fluid therapy in mice (2020)
  • Author(s): Nakano Daisuke、Kitada Kento、Wan Ningning、Zhang Yahua、Wiig Helge、Wararat Kittikulsuth、Yanagita Motoko、Lee Syann、Jia Lin、Titze Jens M.、Nishiyama Akira
  • Journal Title: Kidney International Volume: 97 Issue: 5 Pages: 904-912
  • DOI: 10.1016/j.kint.2019.11.024
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Renal sympathetic nerve activity regulates cardiovascular energy expenditure in rats fed high salt (2020)
  • Author(s): Morisawa N, Kitada K, Fujisawa Y, Nakano D, Yamazaki D, Kobuchi S, Li L, Zhang Y, Morikawa T, Konishi Y, Yokoo T, Luft FC, Titze J, Nishiyama A.
  • Journal Title: Hypertension research Volume: Epub Issue: 6 Pages: 482-491
  • DOI: 10.1038/s41440-019-0389-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats (2020)
  • Author(s): Sufiun Abu、Rahman Asadur、Rafiq Kazi、Fujisawa Yoshihide、Nakano Daisuke、Kobara Hideki、Masaki Tsutomu、Nishiyama Akira
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 6 Pages: 2248-2248
  • DOI: 10.3390/ijms21062248
  • Peer Reviewed / Open Access
• [Journal Article] Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease (2020)
  • Author(s): Wan Ningning、Fujisawa Yoshihide、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Rahman Asadur、Nishiyama Akira
  • Journal Title: Hypertension Research Volume: - Issue: 6 Pages: 492-499
  • DOI: 10.1038/s41440-020-0410-8
  • Peer Reviewed
• [Journal Article] The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats (2020)
  • Author(s): Rahman Asadur、Sherajee Shamshad J.、Rafiq Kazi、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Morikawa Takashi、Konishi Yoshio、Imanishi Masahito、Nishiyama Akira
  • Journal Title: Journal of Pharmacological Sciences Volume: 142 Issue: 3 Pages: 124-126
  • DOI: 10.1016/j.jphs.2019.09.014
  • Peer Reviewed
• [Journal Article] Effect of a novel nonsteroidal selective mineralocorticoid receptor antagonist, esaxerenone (CS-3150), on blood pressure and renal injury in high salt-treated type 2 diabetic mice (2019)
  • Author(s): Bhuiyan Abdus Sattar、Rafiq Kazi、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Nishiyama Akira
  • Journal Title: Hypertension Research Volume: 42 Issue: 6 Pages: 892-902
  • DOI: 10.1038/s41440-019-0211-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diuretic Effects of Sodium Glucose Cotransporter 2 Inhibitors and Their Influence on the Renin-Angiotensin System (2019)
  • Author(s): Ansary Tuba M.、Nakano Daisuke、Nishiyama Akira
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 3 Pages: 629-629
  • DOI: 10.3390/ijms20030629
  • Peer Reviewed / Open Access
• [Journal Article] Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats (2019)
  • Author(s): Li Lei、Guan Yu、Kobori Hiroyuki、Morishita Asahiro、Kobara Hideki、Masaki Tsutomu、Nakano Daisuke、Nishiyama Akira
  • Journal Title: Hypertension Research Volume: 42 Issue: 6 Pages: 769-778
  • DOI: 10.1038/s41440-018-0187-1
  • Peer Reviewed
• [Journal Article] A mouse model of renal fibrosis to overcome the technical variability in ischaemia/reperfusion injury among operators (2019)
  • Author(s): Guan Yu、Nakano Daisuke、Zhang Yifan、Li Lei、Tian Ye、Nishiyama Akira
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 10435-10435
  • DOI: 10.1038/s41598-019-46994-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Simultaneous angiotensin receptor blockade and glucagon‐like peptide‐1 receptor activation ameliorate albuminuria in obese insulin‐resistant rats (2019)
  • Author(s): Rodriguez Ruben、Escobedo Benny、Lee Andrew Y.、Thorwald Max、Godoy‐Lugo Jose A.、Nakano Daisuke、Nishiyama Akira、Parkes David G.、Ortiz Rudy M.
  • Journal Title: Clinical and Experimental Pharmacology and Physiology Volume: 47 Issue: 3 Pages: 422-431
  • DOI: 10.1111/1440-1681.13206
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nrf2-related gene expression is impaired during a glucose challenge in type II diabetic rat hearts (2019)
  • Author(s): Thorwald Max A.、Godoy-Lugo Jose A.、Rodriguez Gema J.、Rodriguez Marco Antonio、Jamal Mostofa、Kinoshita Hiroshi、Nakano Daisuke、Nishiyama Akira、Forman Henry J.、Ortiz Rudy M.
  • Journal Title: Free Radical Biology and Medicine Volume: 130 Pages: 306-317
  • DOI: 10.1016/j.freeradbiomed.2018.10.405
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of the selective chymase inhibitor TEI-F00806 on the intrarenal renin-angiotensin system in salt-treated angiotensin I-infused hypertensive mice (2018)
  • Author(s): Ansary Tuba M.、Urushihara Maki、Fujisawa Yoshihide、Nagata Sayaka、Urata Hidenori、Nakano Daisuke、Hirofumi Hitomi、Kitamura Kazuo、Kagami Shoji、Nishiyama Akira
  • Journal Title: Experimental Physiology Volume: 103 Issue: 11 Pages: 1524-1531
  • DOI: 10.1113/ep087209
  • NAID: 130007900469
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Sympathetic Nervous Activity. (2018)
  • Author(s): Wan N, Rahman A, Hitomi H, Nishiyama A.
  • Journal Title: Front Endocrinol Volume: 26 Pages: 421-421
  • DOI: 10.3389/fendo.2018.00421
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease (2018)
  • Author(s): Nishiyama Akira
  • Journal Title: Hypertension Research Volume: 42 Issue: 3 Pages: 293-300
  • DOI: 10.1038/s41440-018-0158-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice. (2018)
  • Author(s): Zhang Y, Nakano D, Guan Y, Hitomi H, Uemura A, Masaki T, Kobara H, Sugaya T, Nishiyama A.
  • Journal Title: Kidney Int Volume: 94 Issue: 3 Pages: 524-535
  • DOI: 10.1016/j.kint.2018.05.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats (2018)
  • Author(s): Rodriguez Ruben、Moreno Meagan、Lee Andrew Y.、Godoy-Lugo Jose A.、Nakano Daisuke、Nishiyama Akira、Parkes David、Awayda Mouhamed S.、Ortiz Rudy M.
  • Journal Title: Hypertension Research Volume: 41 Issue: 10 Pages: 798-808
  • DOI: 10.1038/s41440-018-0070-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Angiotensin receptor and tumor necrosis factor-α activation contributes to glucose intolerance independent of systolic blood pressure in obese rats (2018)
  • Author(s): Rodriguez Ruben、Lee Andrew、Mathis Keisa W.、Broome Hanna J.、Thorwald Max、Martinez Bridget、Nakano Daisuke、Nishiyama Akira、Ryan Michael J.、Ortiz Rudy M.
  • Journal Title: American Journal of Physiology-Renal Physiology Volume: 315 Issue: 4 Pages: F1081-F1090
  • DOI: 10.1152/ajprenal.00156.2018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of an SGLT2 inhibitor on the systemic and intrarenal renin-angiotensin system in subtotally nephrectomized rats. (2018)
  • Author(s): Li L, Konishi Y, Morikawa T, Zhang Y, Kitabayashi C, Kobara H, Masaki T, Nakano D, Hitomi H, Kobori H, Nishiyama A.
  • Journal Title: J. Pharmacol. Sci. Volume: 137 Issue: 2 Pages: 220-223
  • DOI: 10.1016/j.jphs.2017.10.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats (2018)
  • Author(s): Rodriguez Ruben、Minas Jacqueline N、Vazquez-Medina Jose Pablo、Nakano Daisuke、Parkes David G、Nishiyama Akira、Ortiz Rudy M
  • Journal Title: Journal of Endocrinology Volume: 237 Issue: 3 Pages: 271-284
  • DOI: 10.1530/joe-17-0678
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Guanylyl cyclase A in both renal proximal tubular and vascular endothelial cells protects the kidney against acute injury in rodent experimental endotoxemia models. (2018)
  • Author(s): Kidney against Acute Injury in Rodent Experimental Endotoxemia Models. Kitamura H, Nakano D, Sawanobori Y, Asaga T, Yokoi H, Yanagita M, Mukoyama M, Tokudome T, Kangawa K, Shirakami G, Nishiyama A.
  • Journal Title: Anesthesiology Volume: 印刷中 Issue: 2 Pages: 296-310
  • DOI: 10.1097/aln.0000000000002214
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Independent regulation of renin?angiotensin?aldosterone system in the kidney (2018)
  • Author(s): Nishiyama Akira、Kobori Hiroyuki
  • Journal Title: Clinical and Experimental Nephrology Volume: 22 Issue: 6 Pages: 1231-1239
  • DOI: 10.1007/s10157-018-1567-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel approach to adenine-induced chronic kidney disease associated anemia in rodents. (2018)
  • Author(s): Rahman A, Yamazaki D, Sufiun A, Kitada K, Hitomi H, Nakano D, Nishiyama A.
  • Journal Title: PLoS One Volume: 13 Issue: 2 Pages: e0192531-e0192531
  • DOI: 10.1371/journal.pone.0192531
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 肝細胞がんラットは，組織ナトリウム・体液貯留を伴う体質量の減少を示す. (2022)
  • Author(s): 北田研人，木戸口慧，中野大介，西山成．
  • Organizer: 第95回日本薬理学会年会
• [Presentation] デキサメタゾンは皮膚のナトリウム・水分含量を減少させる. (2021)
  • Author(s): 北田研人. 森澤紀彦. 中野大介. Jens T. 西山成.
  • Organizer: 第94回日本薬理学会年会
• [Presentation] 高血圧合併心不全ラットに対する新規の非ステロイド型MRブロッカーの薬効検討. (2021)
  • Author(s): 西山 成、澤野達哉、中野大介、北田研人、今村武史、ラフマン アサダ.
  • Organizer: 第31回日本循環薬理学会
• [Presentation] New concept of salt and water balance (2020)
  • Author(s): Akira Nishiyama
  • Organizer: 第24回日本心血管内分泌代謝学会学術総会
  • Invited
• [Presentation] （プロ）レニン受容体をターゲットとした癌に対する新規診断治療法の開発 (2020)
  • Author(s): 西山 成
  • Organizer: 第41回日本臨床薬理学会学術総会シンポジウム
• [Presentation] ミネラルコルチコイド受容体ブロッカー (2020)
  • Author(s): 西山 成
  • Organizer: 第50回日本腎臓学会東部学術大会シンポジウム
• [Presentation] 皮膚におけるナトリウム貯留と電解質調節 (2020)
  • Author(s): 西山 成
  • Organizer: 第63回日本腎臓学会学術総会シンポジウム
• [Presentation] 塩と病態生理・MR阻害薬 (2020)
  • Author(s): 西山 成
  • Organizer: 第63回日本糖尿病学会シンポジウム
• [Presentation] DKD治療におけるRAS阻害剤とMR拮抗薬への期待 (2020)
  • Author(s): 西山 成
  • Organizer: 第35回日本糖尿病合併症学会
• [Presentation] SGLT2阻害薬の腎保護作用のメカニズム (2020)
  • Author(s): 西山 成
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone(CS-3150),on blood pressure and urinary angiotensinogen in low-renin dahl satl-sensitive hypertensive rats (2019)
  • Author(s): Nishiyama A, Nakako D, Kobori H, Li L.
  • Organizer: World Congress of Nephrology. 2019
  • Int'l Joint Research
• [Presentation] Renal denervation attenuates a catabolic state in mice fed high salt (2019)
  • Author(s): Yamazaki D, Kitada K, Morisawa N, Fujisawa Y, Nakano D, HItomi H, Titze J, Nishiyama A.
  • Organizer: Hypertension 2019 Scientific Sessions.
  • Int'l Joint Research
• [Presentation] Antiproliferative effects of monoclonal antibodies against (pro)renin receptor in pancreatic ductal adenocarcinoma. (2019)
  • Author(s): Rahman A, Matsuyama M, Shibayama Y, Ebihara A, Nishiyama A.
  • Organizer: Hypertension 2019 Scientific Sessions.
  • Int'l Joint Research
• [Presentation] Anemia Disrupts Renal Compensatory Responses After Uninephrectomy in Mice. (2019)
  • Author(s): Nakano D, Nishiyama A.
  • Organizer: Annual Meetings of American Society of Nephrology.
  • Int'l Joint Research
• [Presentation] Renoprotective effects of nonsteroidal MR blockers. (2019)
  • Author(s): Nishiyama A.
  • Organizer: Asian Pacific Congress of Hypertension 2019.
  • Int'l Joint Research / Invited
• [Presentation] 食塩過剰摂取で生じるカタボリズム (2019)
  • Author(s): 西山 成
  • Organizer: 第19回日本ＮＯ学会学術集会
  • Invited
• [Presentation] 食塩感受性高血圧の新しい機序 (2019)
  • Author(s): 西山 成
  • Organizer: 第42回日本高血圧学会総会
  • Invited
• [Presentation] Effects of a SGLT2 inhibitor on blood pressure and sympathetic nervous activity in salt-treated CKD rats. (2018)
  • Author(s): Nakano D, Yifan Z, Nishiyama A
  • Organizer: Pulse of Asia 2018
• [Presentation] High Salt Intake Induces Catabolism Accompanied By Hepatic Urea Osmolyte Production And Decreases Renal Sympathetic Nerve Activity (2018)
  • Author(s): Morisawa N, Kitada K, Yamazaki D, Nakano D, Fujisawa Y, Nishiyama A.
  • Organizer: AHA Joint Hypertension 2018
• [Presentation] (Pro)renin Receptor Promotes Colorectal Cancer through the Wnt/Beta-Catenin Signaling Pathway despite Constitutive Pathway Component Mutations. (2018)
  • Author(s): Nishiyama A, Shibayama Y, Wang J.
  • Organizer: AHA Joint Hypertension 2018
• [Book] エース薬理学 (2020)
  • Author(s): 金井好克、安西尚彦、安藤 仁、浅井 聰
  • Total Pages: 303
  • Publisher: 南山堂
  • ISBN: 9784525140717
• [Book] カラー 新しい薬理学 (2018)
  • Author(s): 石井邦明、西山 成
  • Total Pages: 588
  • Publisher: 西村書店
  • ISBN: 9784890134854
• [Remarks] 香川大学医学部薬理学ホームページ
  • URL: http://www.kms.ac.jp/%7Eyakuri/
• [Remarks] 香川大学医学部薬理学ホームページ・業績欄
  • URL: http://www.kms.ac.jp/%7Eyakuri/4-4_paperMISC.html
• [Remarks] 香川大学医学部薬理学ホームページ
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• [Remarks] 香川大学医学部薬理学ホームページ
  • URL: http://www.kms.ac.jp/~yakuri/