|Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|Outline of Final Research Achievements
The average life expectancy in Japan raises, whereas there is a big gap between the life span and “healthy” life span. Age-related sarcopenia is known to be associated with decreasing physical activity and healthy life span. Skeletal muscle plasticity is impaired with aging: Muscle hypertrophic response to overload training is markedly attenuated in the elderly compared with that of young. The mechanism of reduced muscle hypertrophic response is largely unknown but it may relate to the susceptibility to sarcopenia. In this study, we showed that the expression levels of the cell polarity protein Scrib are decreased in muscle of aged mice, which involved in a decline in hypertrophic response to overloading stimulation.