• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of method for ameliorating social jet lag by chrono-nutrition and chrono-exercise

Research Project

Project/Area Number 18H03198
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionWaseda University

Principal Investigator

樋口 満  早稲田大学, スポーツ科学学術院, 名誉教授 (20192289)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords社会的時差ボケ / 時間栄養学 / 時間運動学 / 時計遺伝子 / 生活リズム / 動脈スティフネス / 早朝血圧 / 生体リズム / 時間栄養・運動学 / 代謝異常
Outline of Annual Research Achievements

本年度は、一過性の社会的時差ボケが心血管代謝リスクに及ぼす因果関係を明らかにするため、クロスオーバー介入研究を行った。特に、心血管疾患の重要なリスク因子である動脈スティフネスと早朝の血圧上昇に着目して研究を行った。
対象は14名の若年男性とした。介入開始前の1週間、ウェアラブルデバイス(Fitbit)を用いて普段の起床・就寝時刻および睡眠時間を調査した。対象者をランダムに社会的時差ボケ(SJL)条件とコントロール(CON)条件に振り分け、金曜日の午前中に中心動脈スティフネス(cfPWV)などの測定を実施した。また、事前に対象者に渡した24時間血圧計を用いて夜間から早朝の血圧を1時間おきに測定し、早朝の血圧上昇を評価した。その後、SJL条件の者は、金曜日の夜から日曜日の朝にかけて、普段の起床・就寝時刻より3時間遅い時刻に起床・就寝した。CON条件の者は、金曜日の夜から日曜日の朝にかけて、平日と同じ時刻に起床・就寝した。月曜日の午前中に再度各測定を行い、金曜日から月曜日にかけてのcfPWVおよび早朝の血圧上昇の変化をSJL条件とCON条件で比較した。その後、SJL条件とCON条件を入れ替え、同様の介入を行った。
睡眠中央時刻(起床・就寝時刻の中央値)は、SJL条件において平均で2時間58分後退し、CON条件においては平均で13分後退した。睡眠時間に条件間で差は認めらなかった。CON条件では金曜日と月曜日のcfPWVに差は認めらなかったが、SJL条件では金曜日と比較して月曜日にcfPWVが増加した。また、CON条件では金曜日と月曜日で早朝血圧の変化量に差は認めらなかったが、SJL条件では金曜日と比較して月曜日における早朝血圧の変化量が大きかった。以上の結果より、一過性の社会的時差ボケは動脈スティフネスを高め、早朝の血圧上昇を亢進する可能性が示唆された。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

14名を対象として介入研究を実施し、一過性の社会的時差ボケが動脈スティフネスおよび早朝の血圧上昇を亢進させるという知見を得られたため。

Strategy for Future Research Activity

本年度の介入研究で動脈スティフネスと共に測定した動脈圧受容器反射感受性や自律神経指標の解析を行い、一過性の社会的時差ボケが動脈スティフネスや早朝の血圧上昇を亢進させるメカニズムを検討する。また、血中の糖脂質代謝指標や炎症指標などの解析を行い、一過性の社会的時差ボケが代謝異常に及ぼす影響を検討する。
本年度の介入研究において、一過性の社会的時差ボケにより動脈スティフネスの上昇が認められなかった対象者は、身体活動量が高い傾向が認められた。そこで、来年度は身体活動に着目して、社会的時差ボケの是正策の提案に向けた介入研究を行う。具体的には、週末に身体活動量を増やすことにより、一過性の社会的時差ボケに伴う週明けの動脈スティフネスの増加や早朝の血圧上昇が抑制されるか否かを検討する。また、身体活動の実施時刻(朝もしくは夜)によってこれらの抑制効果が異なるか否かを検討する。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(28 results)

All 2022 2021 2020 2019 2018

All Journal Article (23 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 23 results,  Open Access: 20 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (3 results)

  • [Journal Article] The combination of cardiorespiratory fitness and muscular fitness, and prevalence of diabetes mellitus in middle-aged and older men: WASEDA'S Health Study2022

    • Author(s)
      Wang D, Sawada SS, Tabata H, Kawakami R, Ito T, Tanisawa K, Higuchi M, Ishii K, Oka K, Suzuki K, Sakamoto S
    • Journal Title

      BMC Public Health

      Volume: 22(1) Pages: 626-626

    • DOI

      10.1186/s12889-022-12971-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between alcohol dietary pattern and prevalence of dyslipidaemia: WASEDA'S Health Study2022

    • Author(s)
      Tanisawa K, Ito T, Kawakami R, Usui C, Kawamura T, Suzuki K, Sakamoto S, Ishii K, Muraoka I, Oka K, Higuchi M
    • Journal Title

      British Journal of Nutrition

      Volume: - Pages: 1-11

    • DOI

      10.1017/s0007114521002671

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association Between Dietary Patterns and Different Metabolic Phenotypes in Japanese Adults: WASEDA'S Health Study2021

    • Author(s)
      Tanisawa K, Ito T, Kawakami R, Usui C, Kawamura T, Suzuki K, Sakamoto S, Ishii K, Muraoka I, Oka K, Higuchi M
    • Journal Title

      Clinical Nutrition

      Volume: 40(11) Pages: 5523-5530

    • DOI

      10.1016/j.clnu.2021.09.032

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study2021

    • Author(s)
      Kawamura T, Tanisawa K, Kawakami R, Usui C, Ito T, Tabata H, Nakamura N, Kurosawa S, Choi W, Ma S, Radak Z, Sawada SS, Suzuki K, Ishii K, Sakamoto S, Oka K, Higuchi M, Muraoka I
    • Journal Title

      Oxidative Medicine and Cellular Longevity

      Volume: - Pages: 1-11

    • DOI

      10.1155/2021/5566880

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Greater arterial wall viscosity in endurance-trained men2021

    • Author(s)
      Kawano H, Asaka M, Yamamoto K, Gando Y, Konishi M, Sakamoto S, Miyachi M, Higuchi M
    • Journal Title

      European Journal of Applied Physiology

      Volume: 121(8) Pages: 2219-2228

    • DOI

      10.1007/s00421-021-04686-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Response to the Letter to the Editor Regarding "Effect of Vitamin D Supplementation on Body Composition and Physical Fitness in Healthy Adults: A Double-Blind, Randomized Controlled Trial"2020

    • Author(s)
      Sun X, Tanisawa K, Zhang Y, Ito T, Oshima S, Higuchi M, Cao ZB
    • Journal Title

      Ann Nutr Metab

      Volume: in press

    • DOI

      10.1159/000507106

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Micronutrient Intake Adequacy in Men and Women with a Healthy Japanese Dietary Pattern2019

    • Author(s)
      Ito T, Tanisawa K, Kawakami R, Usui C, Ishii K, Suzuki K, Sakamoto S, Muraoka I, Oka K, Higuchi M
    • Journal Title

      Nutrients

      Volume: 12(1) Pages: 6-6

    • DOI

      10.3390/nu12010006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sun X, Tanisawa K, Zhang Y, Ito T, Oshima S, Higuchi M, Cao ZB. Effect of Vitamin D Supplementation on Body Composition and Physical Fitness in Healthy Adults: A Double-Blind, Randomized Controlled Trial2019

    • Author(s)
      Sun X, Tanisawa K, Zhang Y, Ito T, Oshima S, Higuchi M, Cao ZB
    • Journal Title

      Ann Nutr Metab

      Volume: in press

    • DOI

      10.1159/000504873

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of day-to-day variations in physical activity with postprandial appetite regulation in lean young males2019

    • Author(s)
      Ando T、Higuchi M、Tanaka S
    • Journal Title

      Nutrients

      Volume: 11 Pages: 2267-2267

    • DOI

      10.3390/nu11102267

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-Osteoporotic Effect of Soy Isoflavones Intake on Low Bone Mineral Density Caused by Voluntary Exercise and Food Restriction in Mature Female Rats2019

    • Author(s)
      Yanaka K, Higuchi M, Ishimi Y
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 65(4) Issue: 4 Pages: 335-342

    • DOI

      10.3177/jnsv.65.335

    • NAID

      130007697546

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ageing affects the association between serum 25- hydroxyvitamin D concentrations and cardiorespiratory fitness in middle-aged and elderly men2019

    • Author(s)
      Sun X, Tanisawa K, Ito T, Oshima S, Higuchi M, Cao ZB
    • Journal Title

      Asia Pac J Clin Nutr

      Volume: 28(3) Pages: 614-620

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of watching professional baseball at a stadium on health-related outcomes among Japanese older adults: A randomized controlled trial2019

    • Author(s)
      Kawakami Ryoko、Sawada S Susumu、Ito Tomoko、Gando Yuko、Fukushi Tomohiro、Yoshino Atsushi、Kurita Satoshi、Oka Koichiro、Sakamoto Shizuo、Higuchi Mitsuru
    • Journal Title

      Geriatr Gerontol Int

      Volume: 印刷中 Pages: 717-722

    • DOI

      10.1111/ggi.13687

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leisure-time physical activity and DNA damage among Japanese workers2019

    • Author(s)
      Kawakami Ryoko、Kashino Ikuko、Kasai Hiroshi、Kawai Kazuaki、Li Yun-Shan、Nanri Akiko、Higuchi Mitsuru、Mizoue Tetsuya
    • Journal Title

      PLoS One

      Volume: 14

    • DOI

      10.1371/journal.pone.0212499

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Serum 25-Hydroxyvitamin D Concentrations With Glucose Profiles in Male Collegiate Football Athletes2019

    • Author(s)
      Sun X, Cao ZB, Tanisawa K, Oshima S, Higuchi M
    • Journal Title

      International Journal of Sport Nutrition and Exercise Metabolism

      Volume: 26 Pages: 1-6

    • DOI

      10.1123/ijsnem.2018-0225

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome2019

    • Author(s)
      Abraham D, Feher J, Scuderi GL, Szabo D, Dobolyi A, Cservenak M, Juhasz J, Ligeti B, Pongor S, Gomez-Cabrera MC, Vina J, Higuchi M, Suzuki K, Boldogh I, Radak Z
    • Journal Title

      Exp Gerontol

      Volume: 115 Pages: 122-131

    • DOI

      10.1016/j.exger.2018.12.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dietary patterns and abdominal obesity in middle-aged and elderly Japanese adults: Waseda Alumni's Sports, Exercise, Daily Activity, Sedentariness and Health Study (WASEDA'S Health Study)2019

    • Author(s)
      Ito T, Kawakami R, Tanisawa K, Miyawaki R, Ishii K, Torii S, Suzuki K, Sakamoto S, Muraoka I, Oka K, Higuchi M; WASEDA'S Health Study Group
    • Journal Title

      Nutrition

      Volume: 58 Pages: 149-155

    • DOI

      10.1016/j.nut.2018.05.029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise Effects on Physiological Function during Aging.2019

    • Author(s)
      Z Radak, F Torma, I Berkes, S Goto, T Mimura, A Posa, L Balogh,K Suzuki et al.
    • Journal Title

      Free Radic Biol Med

      Volume: 132 Pages: 33-4

    • DOI

      10.1016/j.freeradbiomed.2018.10.444

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preexercise Carbohydrate Ingestion and Transient Hypoglycemia2019

    • Author(s)
      S. Kondo, K. Tanisawa, K. Suzuki, S. Terada, M. Higuchi
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 51(1) Pages: 168-168

    • DOI

      10.1249/mss.0000000000001773

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of short-term endurance exercise on gut microbiota in elderly men2018

    • Author(s)
      Taniguchi H, Tanisawa K, Sun X, Kubo T, Hoshino Y, Hosokawa M, Takeyama H, Higuchi M
    • Journal Title

      Physiological Reports

      Volume: 6(23)

    • DOI

      10.14814/phy2.13935

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of Different Loads on Force-Time Characteristics during Back Squats2018

    • Author(s)
      Kubo T, Hirayama K, Nakamura N, Higuchi M
    • Journal Title

      J Sports Sci Med

      Volume: 17(4) Pages: 617-622

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Accommodating Elastic Bands on Mechanical Power Output during Back Squats2018

    • Author(s)
      Takafumi Kubo, Kuniaki Hirayama, Nobuhiro Nakamura, Mitsuru Higuchi
    • Journal Title

      Sports (Basel)

      Volume: 6 Pages: 151-151

    • DOI

      10.3390/sports6040151

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum 25-Hydroxyvitamin D Concentrations Are Inversely Correlated with Hepatic Lipid Content in Male Collegiate Football Athletes2018

    • Author(s)
      Sun X, Cao ZB, Tanisawa K, Oshima S, Higuchi M
    • Journal Title

      Nutrients

      Volume: 10(7)

    • DOI

      10.3390/nu10070942

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time Course of Decrease in Skeletal Muscle Mitochondrial Biogenesis after Discontinuation of High-Fat Diet2018

    • Author(s)
      Li X, Higashida K, Kawamura T, Higuchi M
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 64(3) Issue: 3 Pages: 233-238

    • DOI

      10.3177/jnsv.64.233

    • NAID

      130007413184

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Exercise and dietary lifestyle for senior health2018

    • Author(s)
      Higuchi M
    • Organizer
      MIRAI Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dietary Pattern and Physical Activity for Senior Health -WASEDA'S Health Study-2018

    • Author(s)
      Higuchi M
    • Organizer
      Taiwan society for sports nutrition Annual Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 体力の正体は筋肉2018

    • Author(s)
      樋口 満
    • Total Pages
      192
    • Publisher
      集英社
    • ISBN
      9784087210309
    • Related Report
      2018 Annual Research Report
  • [Book] 栄養・スポーツ系の運動生理学2018

    • Author(s)
      樋口 満 (監修), 湊 久美子 (編集), 寺田 新 (編集)
    • Total Pages
      208
    • Publisher
      南江堂
    • ISBN
      9784524237975
    • Related Report
      2018 Annual Research Report
  • [Book] トレーニングのための生理学的知識2018

    • Author(s)
      Zsolt Radak (著), 樋口 満 (監訳)
    • Total Pages
      195
    • Publisher
      市村出版
    • ISBN
      9784902109504
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-12-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi