|Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
|Outline of Final Research Achievements
In our current study, we conducted a risk assessment of fluorene 9-bisphenol (BHPF), an alternative bisphenol A for which no risk assessment has yet been done. We evaluated the toxicity of BHPF using guideline-based toxicity test and also examined the details of its endocrine disrupting effects using estrogen-responsive reporter mice, which we have established. As a result, we were able to identify a non-observed adverse effect level of BHPF as well as a dose range in which it can be safely used. BHPF was also detected in human blood, although not at high levels, suggesting that humans are also exposed to a certain amount of BHPF.