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Effects of fine particulate matter and its components for maternal and foetal health

Research Project

Project/Area Number 18H03388
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 63040:Environmental impact assessment-related
Research InstitutionToho University

Principal Investigator

MICHIKAWA Takehiro  東邦大学, 医学部, 講師 (80594853)

Co-Investigator(Kenkyū-buntansha) 高見 昭憲  国立研究開発法人国立環境研究所, 地域環境研究センター, 研究センター長 (00262030)
諸隈 誠一  九州大学, 医学研究院, 教授 (50380639)
山崎 新  国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 副研究センター長 (80391168)
清水 厚  国立研究開発法人国立環境研究所, 地域環境研究センター, 主任研究員 (90332238)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords微小粒子状物質 / 成分 / 妊娠合併症 / 出生体重 / 環境疫学 / PM2.5 / 化学組成 / 胎盤重量 / 黄砂 / 周産期 / 常位胎盤早期剥離 / 短期曝露 / 常位胎盤性早期剥離 / 炎症
Outline of Final Research Achievements

There is evidence that PM2.5 exposure during pregnancy was associated with maternal and foetal health, but such evidence is limited in Asian countries. In this study, we focused on PM2.5 and its components, and examined these effects on perinatal health. We observed that specific components of PM2.5 were inversely associated with birth weight and placental weight, as indicators of foetal growth, and were positively associated with the occurrence of placenta-mediated pregnancy complications. For Asian dust that is a natural phenomenon in which dust
particles are transported from the inner area of China, short-term exposure on the 1-2 days before delivery might increase the risk of placental abruption.

Academic Significance and Societal Importance of the Research Achievements

本研究では、世界的にも知見が限定的である妊婦へのPM2.5とその成分曝露による周産期影響について、ここ10年内のデータを利用して日本における知見を報告した。現在の日本のPM2.5濃度においても、妊娠中の曝露が妊婦とその子ども(胎児)に影響する可能性を示したことで、今後「PM2.5と妊婦とその子どもの健康の関連性が因果関係にあるのか」踏み込んで検討するという次なる課題が明確になった。また、黄砂と早期剥離との関連性については、まだよく分かっていない早期剥離の発生メカニズムの解明につながる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (12 results)

All 2021 2020 2019 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Exposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study2021

    • Author(s)
      Takehiro Michikawa, Seiichi Morokuma, Shin Yamazaki, Akinori Takami, Seiji Sugata, Ayako Yoshino, Yuki Takeda, Kazushige Nakahara, Shinji Saito, Junya Hoshi, Kiyoko Kato, Hiroshi Nitta, Yuji Nishiwaki.
    • Journal Title

      Journal of Exposure Science & Environmental Epidemiology

      Volume: - Issue: 1 Pages: 135-145

    • DOI

      10.1038/s41370-021-00299-4

    • NAID

      120007044571

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trimester-specific association of maternal exposure to fine particulate matter and its components with birth and placental weight in Japan2021

    • Author(s)
      Yuki Takeda, Takehiro Michikawa, Seiichi Morokuma, Shin Yamazaki S, Kazushige Nakahara, Ayako Yoshino, Seiji Sugata, Akinori Takami, Shinji Saito, Junya Hoshi, Kiyoko Kato, Hiroshi Nitta, Yuji Nishiwaki.
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 黄砂飛来後に常位胎盤早期剥離が増える? 周産期にかかる最新の環境疫学研究.2020

    • Author(s)
      道川武紘.
    • Journal Title

      Perinatal Care

      Volume: 39 Pages: 82-87

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 黄砂の健康影響2020

    • Author(s)
      西脇祐司, 道川武紘.
    • Journal Title

      新薬と臨床

      Volume: 69 Pages: 202-205

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Exposure to Asian dust within a few days of delivery is associated with placental abruption in Japan: a case‐crossover study2019

    • Author(s)
      Michikawa T、Yamazaki S、Shimizu A、Nitta H、Kato K、Nishiwaki Y、Morokuma S
    • Journal Title

      BJOG: An International Journal of Obstetrics & Gynaecology

      Volume: 127 Issue: 3 Pages: 335-342

    • DOI

      10.1111/1471-0528.15999

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 化学組成に着目した微小粒子状物質濃度と胎盤関連妊娠合併症との関連性について.2021

    • Author(s)
      道川武紘,諸隈誠一,山崎新,高見昭憲,菅田誠治,吉野彩子,武田悠希,中原一成,齊藤伸治,星純也,加藤聖子,新田裕史,西脇祐司.
    • Organizer
      第31回日本疫学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 妊娠期間中の微小粒子状物質成分濃度と出生時体重との関連 ~妊娠3半期別の検討.2021

    • Author(s)
      武田悠希,道川武紘,諸隈誠一,山崎新,高見昭憲,菅田誠治,吉野彩子,中原一成, 齊藤伸治,星純也,加藤聖子,新田裕史,西脇祐司.
    • Organizer
      第31回日本疫学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 妊娠中の微小粒子状物質濃度は早産と関連しているのか:東京23区での検討.2021

    • Author(s)
      道川武紘,諸隈誠一,山崎新,武田悠希,中原一成, 齊藤伸治,星純也,加藤聖子,新田裕史,西脇祐司.
    • Organizer
      第91回日本衛生学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 妊娠中の微小粒子状物質濃度と胎盤重量との関連.2021

    • Author(s)
      武田悠希,道川武紘,諸隈誠一,山崎新,中原一成, 齊藤伸治,星純也,加藤聖子,新田裕史,西脇祐司.
    • Organizer
      第91回日本衛生学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 妊娠初期の微小粒子状物質曝露と常位胎盤早期剥離との関連性について.2020

    • Author(s)
      道川武紘
    • Organizer
      第90回日本衛生学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 黄砂曝露と常位胎盤早期剥離との関連性について2019

    • Author(s)
      道川武紘,山崎新,清水厚,新田裕史,加藤聖子,西脇祐司,諸隈誠一
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 黄砂飛来の数日後に常位胎盤早期剥離が増加 ~人を対象とした疫学研究の成果~

    • URL

      https://www.toho-u.ac.jp/press/2019_index/20191108-1034.html

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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