Development of non-destructive elemental-analysis technique for biological samples
| Project/Area Number |
18H03471
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 80040:Quantum beam science-related
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| Research Institution | Osaka University |
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Principal Investigator |
Abo Satoshi 大阪大学, 基礎工学研究科, 助教 (60379310)
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| Co-Investigator(Kenkyū-buntansha) |
若家 冨士男 大阪大学, 基礎工学研究科, 准教授 (60240454)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | 元素分析 / 非破壊計測 / イオンビーム分析 / 生体試料 |
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| Outline of Final Research Achievements |
A non-destructive elemental-analysis technique for three-dimensional structures in biological samples with nanometer resolution has been developed. Elastic recoil detection (ERD) and Rutherford backscattering (RBS) were used simultaneously for the measurement. ERD and RBS are sensitive to light and heavy elements, respectively. Therefore, both major light elements and trace amounts of heavy elements in biological samples can be detected high sensitivity. To obtain high depth resolution, time-of-flight was used to measure the energy of scattered ions. The elemental distribution can be measured non-destructively in a short measurement time of approximately one hour by using multiple detectors.
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| Academic Significance and Societal Importance of the Research Achievements |
イオンビームを用いた計測技術は、これまで主として半導体材料の評価に用いられてきた。本研究は、この計測技術を汎用化し、生体試料の計測を可能にすることを目的として研究を行った。構成されている元素の種類が非常に少なく、特定の元素のみを高感度に計測する半導体とは異なり、様々な元素で構成されている生体試料では軽元素から重元素までを同時に計測する必要がある。また、計測により試料構造が容易に変化する生体試料を非破壊で計測することも非常に重要である。本研究では、これらが実現可能な計測技術を開発した。
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Report
(5 results)
Research Products
(14 results)
