| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
To elucidate the mechanism of inhibition of cell division by the application of an alternating electric field, experiments using eggs of Xenopus laevis and numerical simulation were conducted. The direction of cell division and cell death could be easily observed as expected. The application of an electric field caused abnormal development of eggs. In the numerical analysis, we were able to predict the effect of cell size and electrical properties on the intensity of the dielectrophoretic force generated in the cell. In addition, we showed that the Taguchi method can be used to study the effects of uncertainties in electrical properties and cell division angles on the strength of the dielectrophoretic force. The optimum condition of the electric field with a high robustness to unpredictable variations in cell size and electrical properties was identified, which would be useful for improving the efficacy of cancer treatment using weak alternating electric fields.
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