| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Kidney transplantation is effective transplantation therapy for renal failure patients of the end stage. However, the survival rate of the transplanted kidney is still low. In this project, we studied the polymeric materials which can selectively modify the cell surface to protect from an attack by innate immune systems. Here we focused on poly(ethylene glycol)-conjugated phospholipid (PEG-lipid) for cell surface modification and its heparin conjugates and evaluated the function. We found that lipid bilayer membrane could be modified with heparin-lipids with keeping anticoagulant activity, and blood coagulation and clotting were inhibited. From this result, we can reconstruct glycocalyx-like structure on the endothelium of kidney by the heparin-lipid, and protect the cell surface by the cell surface modification.
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