|Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|Outline of Final Research Achievements
In this study, it was found that anti-inflammatory macrophages were increased in adipose tissue by inducing apoptosis of the vascular endothelial cells in the tissue via the adipose-vasculature targeted nano drug delivery system (DDS), which was established in the previous study by the principal investigator. Moreover, it was found the increased expression of Cyp1b1 mRNA in the obese adipose vasculature of mice through microarray analysis. Then, it was successfully described that not only angiogenesis but also infiltration of macrophages in obese adipose tissue was significantly inhibited by the administration of the CYP1B1 specific inhibitor via the nanoDDS.