| Project/Area Number |
18H03687
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 14:Plasma science and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高島 圭介 東北大学, 工学研究科, 助教 (70733161)
宮本 浩一郎 東北大学, 工学研究科, 准教授 (70447142)
神崎 展 東北大学, 医工学研究科, 准教授 (10272262)
立川 正憲 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 (00401810)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2021: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2019: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2018: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
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| Keywords | 気液界面プラズマ / 短寿命活性種 / 高速液流 / マイクロ流路 / 生体分子・細胞反応 / 細胞応答 |
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| Outline of Final Research Achievements |
The purpose of this study is to distinguish reactive species generated in gas-liquid interfacial plasmas by their lifetimes, to clarify the generation and extinction processes of "extremely short-lived reactive species", which react and self-dissolve in less than one second, and to experimentally clarify their effects on biomolecules and cells. The research was promoted by constructing an "atmospheric pressure plasma apparatus with high-speed liquid flow".
As a result, we succeeded in the time-resolved measurement of extremely short-lived reactive species (OH radicals and nitrite precursors) in high-speed liquid flow for the first time, and constructed a reaction diffusion model that takes into account the surface localization distribution of OH radicals and consumption by long-lived reactive species. In addition, the effects of the extremely short-lived active species on biomolecules (amino acids) were also clarified.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでに大気圧プラズマ中の活性種を用いた応用研究が盛んに行われてきたが，１秒以下の寿命を持つ極短寿命活性種のみの効果を調べた例は報告がなかった．本研究により，極短寿命活性種の液中での挙動が明らかとなり，数値計算モデルが構築できたことから，生体分子や細胞への極短寿命活性種の固有の作用を調べることが可能となることで，プラズマ医療科学のみならず，いま発展を続けているプラズマ植物科学，プラズマ農業科学へも貢献することができる．
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