|Budget Amount *help
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2021: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2020: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2019: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
|Outline of Final Research Achievements
Aiming to establish a new guideline for catalyst development in asymmetric synthetic reactions, this study successfully developed catalysts that can precisely control the selectivity of reaction substrates based on the concept of "asymmetric tight-lattice reaction space". Based on the QuinoxP* ligand, the substituent pattern on phosphorus was successfully designed with the aid of computational chemistry. We also reported a novel approach to control the steric environment by introducing silicon substituents into the backbone. We also succeeded in synthesizing many new optically active organoboron compounds, and developed mechanochemical synthesis.