Circadian clock oscillation in primate SCN
| Project/Area Number |
18H04015
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 46:Neuroscience and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
冨永 恵子 (吉野恵子) 大阪大学, 生命機能研究科, 准教授 (60256196)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2020: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2019: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2018: ¥21,840,000 (Direct Cost: ¥16,800,000、Indirect Cost: ¥5,040,000)
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| Keywords | 概日リズム / 時計遺伝子 / 視交叉上核 / 時差 / シグナル伝達 / ケモカイン / 自然免疫 / 霊長類 / 生体リズム / リズム発振 / リズム同調 / 哺乳類 / 神経科学 / 生体分子 / 脳・神経 / シスエレメント / ノンコーディングDNA / 細胞・組織 / 遺伝子 / 脳神経機構 |
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| Outline of Final Research Achievements |
Circadian time is coded at the genetic level as clock genes, which ticks time at cell level in the whole body. The suprachiasmatic nucleus (SCN) integrates these diverse times, and control daily sleep-wake rhythms. We carried out the SCN-Gene Project, in which we knocked out each gene highly expressed in the mouse SCN, and examined their circadian behaviors. In these mice, we found that many of them showed abnormal circadian sleep-wake rhythms. By examining these mice, we explored new regulatory mechanisms of circadian rhythms including steroid metabolism, innate immunity, non-coding region of DNA, and RNA methylation. Further, we established an experimental system of circadian rhythms in diurnal primate Callithrix jacchus.
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| Academic Significance and Societal Importance of the Research Achievements |
今回新たに解明したのは、以下の点である。①生体において、蛋白質をコードしないDNA配列が、日々の活動のリズムのスイッチを入れ制御していること、②メチル化と体内時計は、太古の地球から密接な関係を持って進化してきたこと、③ステロイド代謝を介し、涙の脂溶性成分はリズミックに制御されること④新しい光誘導物質が視交叉上核で発現し、リズム変位させること、⑤高齢のマウスの慢性時差による死亡は、バソプレッシン阻害により阻止できること、⑥体内時計はケモカインを介し夜間に自然免疫を発動すること。さらに、昼行性霊長類マーモセットにも概日リズムは存在し、様々なレベルでリズムを駆動することを明らかにした。
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels.2022
Author(s)
Matsuo M, Seo K, Taruno A, Mizoro Y, Yamaguchi Y, Doi M, Nakao R, Kori H, Abe T, Ohmori H, Tominaga K, Okamura H
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Journal Title
Cell Rep
Volume: 39
Issue: 8
Pages: 110844-110844
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling.2020
Author(s)
Greco CM, Cervantes M, Fustin JM, Ito K, Ceglia N, Samad M, Shi J, Koronowski KB, Forne I, Ranjit S, Gaucher J, Kinouchi K, Kojima R, Gratton E, Li W, Baldi P, Imhof A, Okamura H, Sassone-Corsi P.
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Journal Title
Sci Adv
Volume: 6
Issue: 51
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Circadian oscillation of diurnal primate common marmosets (Callithrix jacchus) I. Physiological parameters2018
Author(s)
Maho SUGAWA, Yuka KONO, Teruaki FUJINAGA, Nami SATO, Teruo KANEKO, Aya SHIMADA, Keiko TOMINAGA, Jean-Michel Fustin, Hirotaka ONOE, Jiro YAMASHITA, Kaoru ISA, Tadashi ISA, Hitoshi OKAMURA
Organizer
第41回日本神経科学大会
Related Report
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[Presentation] Circadian oscillation of diurnal primate common marmosets (Callithrix jacchus). II. Cohabitation on rhythmicity2018
Author(s)
Yuka KONO, Maho SUGAWA, Teruaki FUJINAGA, Teruo KANEKO, Aya SHIMADA, Keiko TOMINAGA, Hirotaka ONOE, Kaoru ISA, Tadashi ISA, William J SCHWARTZ, Hitoshi OKAMURA
Organizer
第41回日本神経科学大会
Related Report
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