Fundamental Study of Robust Molecule Recognition Electronics

• Project/Area Number: 18H05243
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Review Section: Broad Section C
• Research Institution: The University of Tokyo (2019-2022); Kyushu University (2018)
• Principal Investigator: 柳田 剛 東京大学, 大学院工学系研究科(工学部), 教授 (50420419)
• Co-Investigator(Kenkyū-buntansha): 安井 隆雄 名古屋大学, 工学研究科, 准教授 (00630584) ; 内田 建 東京大学, 大学院工学系研究科(工学部), 教授 (30446900)
• Project Period (FY): 2018-06-11 – 2023-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥195,260,000 (Direct Cost: ¥150,200,000、Indirect Cost: ¥45,060,000); Fiscal Year 2022: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000); Fiscal Year 2021: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000); Fiscal Year 2020: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000); Fiscal Year 2019: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2018: ¥61,490,000 (Direct Cost: ¥47,300,000、Indirect Cost: ¥14,190,000)
• Keywords: ナノワイヤ / 人工嗅覚システム / ナノ構造 / ナノ材料科学 / センサエレクトロニクス / 分子認識 / 金属酸化物ナノ構造 / 分子センサ

Outline of Annual Research Achievements

本研究のアプローチは、①金属酸化物ナノワイヤの精密結晶成長制御技術を駆使して「ナノワイヤ表面に分子形状を記憶」させた堅牢な分子識別機能の多様な分子群への適用可能性と限界を調べ、②分子識別性を有する酸化物ナノ構造をシリコン基板上で集積化して、堅牢な分子識別酸化物ナノワイヤ構造とセンサとの集積化ハイブリッド分子センサを創製し、③1024個の分子センサを集積化させたセンサアレイを実証する、という3つの段階による。これまでに、ナノワイヤ表面に分子形状を記憶させる新技術の創出に成功し、夾雑分子群から標的分子を電流識別する方法論の原理実証が完了していた。今回は①分子識別の耐熱性及び耐久性を評価し、分子形状記憶が破壊される条件が材料物性とどのように相関するかを検証および②センサチャネル表面構造の変調による分子識別能力の最適化を行い、分子鎖長が同一の分子種における位置異性といったより高度な構造異性を有する分子群の識別へと展開を行ったうえで、③導電性金属酸化物電極材料とナノチャネル構造の新規設計による、長期間安定動作分子センサの高密度集積化の実現に取り組んだ。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

堅牢な分子識別機能を持つナノワイヤ表面の形成評価技術については、400 ℃以上の温度および数百回レベルの繰り返し耐久試験を行い、その堅牢性を評価した。その結果、当初の予想を遥かに超える高温（>600 ℃）処理を経ても耐久性が保たれ、室温換算で数か月以上の長期にわたって分子識別能が保たれることを実証した。既存の分子鋳型の方法論においてこれほど高温・長期使用に耐える例はなく、世界に先駆けた成果と言える。さらに、センサチャネル表面構造の変調を行うことで、分子鎖長が同一の脂肪族ケトンにおける位置異性体の識別に成功した。単純な直鎖脂肪族の位置異性体は分子識別の中でも最難関に位置するものであり、本成果は分子鋳型を用いて炭素一個分の解像度で識別した初めての成果である。さらに、1024個の堅牢な金属酸化物ナノ薄膜分子センサを1平方センチメートル以下の面積に集積化したセンサアレイチップを開発し、1平方センチメートル以下の領域における空気中の分子の濃度分布を可視化することに成功した。

Strategy for Future Research Activity

現在までに開発した堅牢な分子認識表面について、これまでのモデル分子群を基軸とした系統的かつ網羅的な標的物質の探索を行い、その認識能力の適用範囲と限界点を明らかとする。そしてその分子鋳型の形成過程と分子捕捉原理に対して量子化学計算・分子動力学シミュレーションを駆使して迫ることで、本研究成果を新たな学術基盤の創成へと昇華する。そして堅牢な分子識別酸化物ナノワイヤ構造とセンサとの集積化ハイブリッド分子センサを創製について、これまでに得られた分子鋳型による識別技術を電気的な識別へと展開し、1024個の集積化センサアレイチップを用いた生体由来分子群の時系列データ取得に取り組むことで、それらの揮発性有機化合物群データが対象の状態モニタリングに応用可能であることを実証する。

Assessment Rating

Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Research Products

• [Journal Article] Oxygen-Induced Reversible Sn-Dopant Deactivation between Indium Tin Oxide and Single-Crystalline Oxide Nanowire Leading to Interfacial Switching (2020)
  • Author(s): Zeng Hao、Takahashi Tsunaki、Seki Takehito、Kanai Masaki、Zhang Guozhu、Hosomi Takuro、Nagashima Kazuki、Shibata Naoya、Yanagida Takeshi
  • Journal Title: ACS Applied Materials & Interfaces Volume: 12 Issue: 47 Pages: 52929-52936
  • DOI: 10.1021/acsami.0c16108
  • Peer Reviewed
• [Journal Article] Artificial visual systems enabled by quasi?two-dimensional electron gases in oxide superlattice nanowires (2020)
  • Author(s): Meng You、Li Fangzhou、Lan Changyong、Bu Xiuming、Kang Xiaolin、Wei Renjie、Yip SenPo、Li Dapan、Wang Fei、Takahashi Tsunaki、Hosomi Takuro、Nagashima Kazuki、Yanagida Takeshi、Ho Johnny C.
  • Journal Title: Science Advances Volume: 6 Issue: 46
  • DOI: 10.1126/sciadv.abc6389
• [Journal Article] Face-Selecive Crystal Growth of Hydrothermal Tungsten Oxide Nanowires for Sensing Volatile Molecules (2020)
  • Author(s): S. Nekita, K. Nagashima, G. Zhang, Q. Wang, M. Kanai, T. Takahashi, T. Hosomi, K. Nakamura, T. Okuyama and T. Yanagida
  • Journal Title: ACS Applied Nano Materials Volume: 3 Issue: 10 Pages: 10252-10260
  • DOI: 10.1021/acsanm.0c02194
  • Peer Reviewed
• [Journal Article] Perovskite Core?Shell Nanowire Transistors: Interfacial Transfer Doping and Surface Passivation (2020)
  • Author(s): Meng You、Lai Zhengxun、Li Fangzhou、Wang Wei、Yip SenPo、Quan Quan、Bu Xiuming、Wang Fei、Bao Yan、Hosomi Takuro、Takahashi Tsunaki、Nagashima Kazuki、Yanagida Takeshi、Lu Jian、Ho Johnny C.
  • Journal Title: ACS Nano Volume: 14 Issue: 10 Pages: 12749-12760
  • DOI: 10.1021/acsnano.0c03101
• [Journal Article] Phosphonic Acid Modified ZnO Nanowire Sensors: Directing Reaction Pathway of Volatile Carbonyl Compounds (2020)
  • Author(s): C. Wang, T. Hosomi, K. Nagashima, T. Takahashi, G. Zhang, M. Kanai, H. Yoshida and T. Yanagida
  • Journal Title: ACS Applied Materials & Interfaces Volume: 12 Issue: 39 Pages: 44265-44272
  • DOI: 10.1021/acsami.0c10332
  • Peer Reviewed
• [Journal Article] Unusual Sequential Annealing Effect in Achieving High Thermal Stability of Conductive Al-Doped ZnO Nanofilms (2020)
  • Author(s): R. Yan, T. Takahashi, M. Kanai, T. Hosomi, G. Zhang, K. Nagashima and T. Yanagida
  • Journal Title: ACS Applied Electronic Materials Volume: 2 Issue: 7 Pages: 2064-2070
  • DOI: 10.1021/acsaelm.0c00321
  • Peer Reviewed
• [Journal Article] Monovalent Sulfur Oxoanions Enable Millimeter-Long Single Crystalline h-WO3 Nanowire Synthesis (2020)
  • Author(s): Zhang Guozhu、Wang Chen、Mizukami Wataru、Hosomi Takuro、Nagashima Kazuki、Yoshida Hideto、Nakamura Kentaro、Takahashi Tsunaki、Kanai Masaki、Yasui Takao、Aoki Yuriko、Baba Yoshinobu、Yanagida Takeshi
  • Journal Title: Nanoscale Volume: - Issue: 16 Pages: 9058-9066
  • DOI: 10.1039/c9nr10565d
  • Peer Reviewed
• [Journal Article] Synthesis of Monodispersedly Sized ZnO Nanowires from Randomly Sized Seeds (2020)
  • Author(s): X. Zhao, K. Nagashima, G. Zhang, H. Yoshida, T. Takahashi, T. Hosomi, M. Kanai, M. Suzuki, G. Meng, T. Yasui, S. Takeda, Y. Baba and ＊T. Yanagida
  • Journal Title: Nano Letters Volume: 20 Pages: 599-605
  • Peer Reviewed
• [Journal Article] Improvements of Electrical Characteristics of Single-Crystalline ZnO Nanowire Field-Effect Transistors via SelfAssembled Monolayer Modification (2020)
  • Author(s): H. Zeng, T. Takahashi, T. Hosomi, K. Nagashima, M. Kanai, G. Zhang and ＊T. Yanagida
  • Journal Title: Engineering Sciences Reports Volume: 42 Pages: 12-16
  • NAID: 120007053167
  • Peer Reviewed
• [Journal Article] Co-porphyrin functionalized CVD graphene ammonia sensor with high selectivity to disturbing gases: hydrogen and humidity (2020)
  • Author(s): Sawada Kei, Tanaka Takahisa, Yokoyama Takamune, Yamachi Ryosuke, Oka Yuki, Masai Hiroshi, Chiba Yusuke, Terao Jun, Uchida Ken
  • Journal Title: Japanese Journal of Applied Physics Volume: 59 Issue: SG Pages: SGGG09-SGGG09
  • DOI: 10.35848/1347-4065/ab6b80
  • Peer Reviewed / Open Access
• [Journal Article] Peptide Screening from a Phage Display Library for Benzaldehyde Recognition (2019)
  • Author(s): Tanaka Masayoshi、Minamide Taisuke、Takahashi Yuta、Hanai Yosuke、Yanagida Takeshi、Okochi Mina
  • Journal Title: Chemistry Letters Volume: 48 Issue: 8 Pages: 978-981
  • DOI: 10.1246/cl.190318
  • NAID: 130007687695
  • ISSN: 0366-7022, 1348-0715
  • Year and Date: 2019-08-05
  • Peer Reviewed
• [Journal Article] 単結晶金属酸化物ナノワイヤ結晶成長の設計指針 (2019)
  • Author(s): 長島一樹, 高橋綱己, 細見拓郎, 柳田 剛
  • Journal Title: 日本結晶成長学会誌 Volume: 46 Pages: 2-05
  • NAID: 130007688851
  • Peer Reviewed
• [Journal Article] “堅い”金属酸化物無機ナノ構造を用いた“柔らかい”分子群の匂いを識別・記録するエレクトロニクス (2019)
  • Author(s): 細見拓郎、高橋綱己、長島一樹、＊柳田 剛
  • Journal Title: 無機マテリアル学会会誌 Volume: 24 Pages: 346-353
  • Peer Reviewed
• [Journal Article] 酸化物ナノワイヤによる尿中 microRNA の回収と解析 (2019)
  • Author(s): 長縄豪, 安井隆雄, 柳田剛, 加地範匡, 長島一樹, 鷲尾隆, 馬場嘉信
  • Journal Title: 化学とマイクロ・ナノシステム学会誌 Volume: 18 Pages: 34-35
  • Peer Reviewed
• [Journal Article] リキッドバイオプシーの最新動向 (2019)
  • Author(s): 安井隆雄
  • Journal Title: 化学と工業 Volume: 72 Pages: 830-831
  • Peer Reviewed
• [Journal Article] Redox-Inactive CO2 Determines Atmospheric Stability of Electrical Properties of ZnO Nanowire Devices through a Room-Temperature Surface Reaction (2019)
  • Author(s): Nakamura Kentaro、Takahashi Tsunaki、Hosomi Takuro、Seki Takehito、Kanai Masaki、Zhang Guozhu、Nagashima Kazuki、Shibata Naoya、Yanagida Takeshi
  • Journal Title: ACS Applied Materials & Interfaces Volume: 11 Issue: 43 Pages: 40260-40266
  • DOI: 10.1021/acsami.9b13231
  • Peer Reviewed
• [Journal Article] Growth Kinetics and Magnetic Property of Single-Crystal Fe Nanowires Grown via Vapor-Solid Mechanism Using Chemically Synthesized FeO Nanoparticle Catalysts (2019)
  • Author(s): Yanase Takashi、Ogihara Uika、Awashima Yoshihiro、Yanagida Takeshi、Nagashima Kazuki、Nagahama Taro、Shimada Toshihiro
  • Journal Title: Crystal Growth & Design Volume: 19 Issue: 12 Pages: 7257-7263
  • DOI: 10.1021/acs.cgd.9b01148
  • Peer Reviewed
• [Journal Article] Low-Power and ppm-Level Multimolecule Detection by Integration of Self-Heated Metal Nanosheet Sensors (2019)
  • Author(s): Tanaka Takahisa、Yanagida Takeshi、Uchida Ken、Tabuchi Kenta、Tatehora Kohei、Shiiki Yohsuke、Nakagawa Shuya、Takahashi Tsunaki、Shimizu Ryota、Ishikuro Hiroki、Kuroda Tadahiro
  • Journal Title: IEEE Transactions on Electron Devices Volume: 66 Issue: 12 Pages: 5393-5398
  • DOI: 10.1109/ted.2019.2945932
  • Peer Reviewed
• [Journal Article] Controlling Bi Provoked Nanostructure Formation in GaAs/GaAsBi Core-Shell Nanowires (2019)
  • Author(s): Teruyoshi Matsuda, Kyohei Takada, Kosuke Yano, Rikuo Tsutsumi, Kohei Yoshikawa, Satoshi Shimomura, Yumiko Shimizu, Kazuki Nagashima,Takeshi Yanagida, Fumitaro Ishikawa
  • Journal Title: Nano Letters Volume: 19 Issue: 12 Pages: 8510-8510
  • DOI: 10.1021/acs.nanolett.9b02932
  • Peer Reviewed
• [Journal Article] Water?Organic Cosolvent Effect on Nucleation of Solution-Synthesized ZnO Nanowires (2019)
  • Author(s): Akihiro Yuya、Nagashima Kazuki、Hosomi Takuro、Kanai Masaki、Anzai Hiroshi、Takahashi Tsunaki、Zhang Guozhu、Yasui Takao、Baba Yoshinobu、Yanagida Takeshi
  • Journal Title: ACS Omega Volume: 4 Issue: 5 Pages: 8299-8304
  • DOI: 10.1021/acsomega.9b00945
  • Peer Reviewed / Open Access
• [Journal Article] Discrimination of VOCs molecules via extracting concealed features from a temperature-modulated p-type NiO sensor (2019)
  • Author(s): Liu Hongyu、He Yuhui、Nagashima Kazuki、Meng Gang、Dai Tiantian、Tong Bin、Deng Zanhong、Wang Shimao、Zhu Nengwei、Yanagida Takeshi、Fang Xiaodong
  • Journal Title: Sensors and Actuators B: Chemical Volume: 293 Pages: 342-349
  • DOI: 10.1016/j.snb.2019.04.078
  • Peer Reviewed
• [Journal Article] Paper-based disposable molecular sensor constructed from oxide nanowires, cellulose nanofibers, and pencil-drawn electrodes (2019)
  • Author(s): H. Koga, K. Nagashima, Y. Huang, G. Zhang, C. Wang, T. Takahashi, A. Inoue, H. Yan, M. Kanai, Y. He, K. Uetani, M. Nogi, T. Yanagida
  • Journal Title: ACS Applied Materials & Interfaces Volume: 11 Issue: 16 Pages: 15044-15050
  • DOI: 10.1021/acsami.9b01287
  • NAID: 120006955460
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rational Method of Monitoring Molecular Transformations on Metal-Oxide Nanowire Surfaces (2019)
  • Author(s): C. Wang, T. Hosomi, K. Nagashima, T. Takahashi, G. Zhang, M. Kanai, H. Zeng, W. Mizukami, N. Shioya, T. Shimoaka, Y. Aoki, J. Terao, T. Hasegawa and T. Yanagida
  • Journal Title: Nano Lett. Volume: 19 Issue: 4 Pages: 2443-2449
  • DOI: 10.1021/acs.nanolett.8b05180
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Unusual Oxygen Partial Pressure Dependence of Electrical Transport of Single-Crystalline Metal Oxide Nanowires Grown by the Vapor?Liquid?Solid Process (2019)
  • Author(s): H. Anzai, T. Takahashi, M. Suzuki, M. Kanai, G. Zhang, T. Hosomi, T. Seki, K. Nagashima, N. Shibata and T. Yanagida
  • Journal Title: Nano Letters Volume: 19 Issue: 3 Pages: 1675-1681
  • DOI: 10.1021/acs.nanolett.8b04668
  • Peer Reviewed
• [Journal Article] Engineering Nanowire-Mediated Cell Lysis for Microbial Cell Identification (2019)
  • Author(s): Yasui Takao、Yanagida Takeshi、Shimada Taisuke、Otsuka Kohei、Takeuchi Masaki、Nagashima Kazuki、Rahong Sakon、Naito Toyohiro、Takeshita Daiki、Yonese Akihiro、Magofuku Ryo、Zhu Zetao、Kaji Noritada、Kanai Masaki、Kawai Tomoji、Baba Yoshinobu
  • Journal Title: ACS Nano Volume: 13 Pages: 2262-2273
  • DOI: 10.1021/acsnano.8b08959
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microfluidic Mechanotyping of a Single Cell with Two Consecutive Constrictions of Different Sizes and an Electrical Detection System (2019)
  • Author(s): Sano Mamiko、Kaji Noritada、Rowat Amy C.、Yasaki Hirotoshi、Shao Long、Odaka Hidefumi、Yasui Takao、Higashiyama Tetsuya、Baba Yoshinobu
  • Journal Title: Analytical Chemistry Volume: 91 Issue: 20 Pages: 12890-12899
  • DOI: 10.1021/acs.analchem.9b02818
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nanoscale, low-energy molecular sensors for health care and environmental monitoring (2019)
  • Author(s): K. Uchida and T. Tanaka
  • Journal Title: AAPPS Bulletin Volume: 29 Pages: 16-20
  • Peer Reviewed
• [Journal Article] PM_2.5 Particle Detection in a Microfluidic Device by Using Ionic Current Sensing (2018)
  • Author(s): SHIMADA Taisuke、YASAKI Hirotoshi、YASUI Takao、YANAGIDA Takeshi、KAJI Noritada、KANAI Masaki、NAGASHIMA Kazuki、KAWAI Tomoji、BABA Yoshinobu
  • Journal Title: Analytical Sciences Volume: 34 Issue: 12 Pages: 1347-1349
  • DOI: 10.2116/analsci.18C018
  • NAID: 130007528641
  • ISSN: 0910-6340, 1348-2246
  • Year and Date: 2018-12-10
  • Peer Reviewed / Open Access
• [Journal Article] Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer (2018)
  • Author(s): Shimada Taisuke、Yasui Takao、Yokoyama Asami、Goda Tatsuro、Hara Mitsuo、Yanagida Takeshi、Kaji Noritada、Kanai Masaki、Nagashima Kazuki、Miyahara Yuji、Kawai Tomoji、Baba Yoshinobu
  • Journal Title: Lab on a Chip Volume: 18 Issue: 21 Pages: 3225-3229
  • DOI: 10.1039/c8lc00438b
  • Peer Reviewed / Open Access
• [Journal Article] Thermal Conductivity of Si Nanowires with modulated Dopant Distribution by Self-heated 3w Method and Its Length Dependence " (2018)
  • Author(s): F. W. Zhuge, T. Takahashi, M. KanaiK. Nagashima, G. Meng, Y. He, N. Fukata, K. Uchida and ＊T. Yanagida
  • Journal Title: Journal of Applied Physics Volume: 124 Issue: 6 Pages: 065105-065105
  • DOI: 10.1063/1.5039988
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Robust Ionic Current Sensor for Bacterial Cell Size Detection (2018)
  • Author(s): H. Yasaki, T. Shimada, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai and Y. Baba
  • Journal Title: ACS Sensors Volume: 3 Issue: 3 Pages: 574-579
  • DOI: 10.1021/acssensors.8b00045
  • Peer Reviewed / Open Access
• [Journal Article] A real-time simultaneous measurement on a microfluidic device for individual bacteria discrimination (2018)
  • Author(s): H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai and Y. Baba
  • Journal Title: Sensors and Actuators B: Chemical Volume: 260 Pages: 746-752
  • DOI: 10.1016/j.snb.2018.01.079
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Channel Geometry on Ionic Current Signal of a Bridge Circuit Based Microfluidic Channel (2018)
  • Author(s): H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai and Y. Baba
  • Journal Title: Chemistry Letters Volume: 47 Issue: 3 Pages: 350-353
  • DOI: 10.1246/cl.171139
  • NAID: 130006434191
  • ISSN: 0366-7022, 1348-0715
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Evaluation of Dielectric Breakdown of Silicon Micro- and Nanofluidic Devices for Electrophoretic Transport of a Single DNA Molecule (2018)
  • Author(s): Sano Mamiko、Kaji Noritada、Wu Qiong、Naito Toyohiro、Yasui Takao、Taniguchi Masateru、Kawai Tomoji、Baba Yoshinobu
  • Journal Title: Micromachines Volume: 9 Issue: 4 Pages: 180-180
  • DOI: 10.3390/mi9040180
  • NAID: 120006510291
  • Peer Reviewed / Open Access
• [Journal Article] Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells. (2018)
  • Author(s): Yukawa H, Suzuki K, Aoki K, Arimoto T, Yasui T, Kaji N, Ishikawa T, Ochiya T, Baba Y.
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 6765-6765
  • DOI: 10.1038/s41598-018-24563-0
  • Peer Reviewed / Open Access
• [Journal Article] Pd-Functionalized, Suspended Graphene Nanosheet for Fast, Low-Energy Multimolecular Sensors (2018)
  • Author(s): T. Yokoyama, T. Tanaka, Y. Shimokawa, R. Yamachi, Y. Saito and K. Uchida
  • Journal Title: ACS Appl. Nano Mater Volume: 1 Issue: 8 Pages: 3886-3894
  • DOI: 10.1021/acsanm.8b00667
  • Peer Reviewed / Open Access
• [Journal Article] Enhancement of Sensor Response in Graphene Gas Sensors by Gate-Induced Field (2018)
  • Author(s): T. Tanaka, T. Yokoyama and K. Uchida
  • Journal Title: IEEE Electron Dev. Lett Volume: 39 Issue: 12 Pages: 1924-1927
  • DOI: 10.1109/led.2018.2875892
  • Peer Reviewed / Open Access
• [Journal Article] Selective molecular recognition using molecular fingerprinted nanowires" (2018)
  • Author(s): M. Horiuchi, T. Yasui, K. Nagashima, T. Yanagida and Y. Baba
  • Journal Title: Micro Total Analysis Systems Volume: 1 Pages: 659-660
  • Peer Reviewed / Open Access
• [Journal Article] PM2.5 analysis in liquid phase via water film-based collection and microfluidics-based electrical detection (2018)
  • Author(s): T. Shimada, H. Yasaki, T. Yasui, A. Hibara, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai and Y. Baba
  • Journal Title: Micro Total Analysis Systems Volume: 1 Pages: 270-271
  • Peer Reviewed / Open Access
• [Presentation] 大気中分子－ZnOナノワイヤ/Pt界面間相互作用の解明に基づく デバイス特性の高信頼化 (2020)
  • Author(s): 中村健太郎，高橋綱己，金井真樹，Z.Guozhu，細見拓郎，長島一樹，柳田剛
  • Organizer: 第1回VR学術講演会
  • Invited
• [Presentation] SAMによる単結晶酸化亜鉛ナノワイヤ表面化学反応制御 (2020)
  • Author(s): 中村健太郎，清水將博，高橋綱己，金井真樹，Z.Guozhu，細見拓郎，長島一樹，柳田剛
  • Organizer: 第2回VR学術講演会
• [Presentation] Nanowires meet microarray and AI for urine liquid biopsy (2019)
  • Author(s): akao Yasui
  • Organizer: Nanowire week 2019
  • Int'l Joint Research
• [Presentation] Metal Oxide Nanowire Meets Internet of Things (IoT) (2019)
  • Author(s): Takeshi Yanagida
  • Organizer: Workshop in University of Bresia, Bresia, Italy
  • Int'l Joint Research
• [Presentation] “Hard” Metal Oxide Nanowire Surface Discriminates “Soft” Molecules (2019)
  • Author(s): Takeshi Yanagida
  • Organizer: M&BE10, Nara, Japan
  • Int'l Joint Research
• [Presentation] Interface of Nanowires Meets Internet of Things (IoT) (2019)
  • Author(s): Takeshi Yanagida
  • Organizer: Workshop of Chinese Academy of Science (CAS), Heifei, China
  • Int'l Joint Research
• [Presentation] Growth and Transport Properties of Metal Oxide Nanowires (2019)
  • Author(s): Takeshi Yanagida
  • Organizer: IEM, Taipei, Taiwan
  • Int'l Joint Research
• [Presentation] Metal Oxide Nanowires Meet Internet of Things (IoT) (2019)
  • Author(s): Takeshi Yanagida
  • Organizer: Workshop in City University of Hong Kong, Hong Kong, China
  • Int'l Joint Research
• [Presentation] Interfacial Properties of Heterostructured Nanowires and Their IoT Device Applications (2019)
  • Author(s): Takeshi Yanagida
  • Organizer: 2019 NEASymposium, Atami, Japan
  • Int'l Joint Research
• [Presentation] ナノワイヤを用いた尿中細胞外小胞捕捉 (2019)
  • Author(s): 柳田 剛, 安井隆雄
  • Organizer: 文部科学省ナノテクノロジープラットフォーム 秀でた利用成果
  • Invited
• [Presentation] Low-power and ppm-Level Detection of Gas Molecules by Integrated Metal Nanosheets (2019)
  • Author(s): 田中貴久，田渕健太，舘洞康平，椎木陽介，中川修哉，高橋綱己，清水涼太，石黒仁揮，黒田忠広，柳田剛， 内田建
  • Organizer: VLSI シンポジウム報告会
  • Invited
• [Presentation] 堅牢な分子識別センサ (2019)
  • Author(s): 柳田 剛
  • Organizer: 科学技術未来戦略ワークショップ「多様なデータの取得・統合処理を可能にするセンサ融合基盤技術~セ ンシング情報の高付加価値化に向けて~」
  • Invited
• [Presentation] 空間選択性の結晶成長に立脚した堅牢な分子識別エレクトロニクス (2019)
  • Author(s): 柳田 剛
  • Organizer: 2019 年度第 3 回PE 研究会
  • Invited
• [Presentation] 自己組織化現象の理解に基づいた３次元ナノ構造設計とIoT ナノデバイスへの展開 (2019)
  • Author(s): 柳田 剛
  • Organizer: 大阪大学ナノ理工学人材育成産学コンソーシアム2019 ナノ理工学セミナー 「ナノマテリアル開発の最前線」
  • Invited
• [Presentation] 尿中mRNA を超高感度検出するナノワイヤデバイス (2019)
  • Author(s): 柳田 剛
  • Organizer: Nano Tech 2019
  • Invited
• [Presentation] 自己組織化現象の理解に基づいた３次元ナノ構造設計と IoT ナノデバイスへの展開 (2019)
  • Author(s): 柳田剛
  • Organizer: 第 94 回 大阪大学工業会機械工学系 技術交流会 －自己治癒・自己組織化材料によるものづくり戦略、
  • Invited
• [Presentation] 尿中 mRNA を超高感度検出するナノワイヤデバイス (2019)
  • Author(s): 柳田剛
  • Organizer: Nano Tech 2019
  • Invited
• [Presentation] Growth and Transport Properties of Metal Oxide Nanowires (2018)
  • Author(s): Takeshi Yanagida
  • Organizer: Material Research Society (MRS) Fall Meeting
  • Int'l Joint Research / Invited
• [Presentation] Impact of Flux Window Principle on Oxide Nanowires and Their Properties (2018)
  • Author(s): Takeshi Yangida
  • Organizer: Korean Physics Society (KPS) Meeting
  • Int'l Joint Research / Invited
• [Presentation] Single Crystalline Metal Oxide Nanowire (2018)
  • Author(s): Takeshi Yanagida
  • Organizer: 2nd Workshop on Functional Materials Science (FMS)
  • Int'l Joint Research / Invited
• [Presentation] Single Crystalline Metal Oxide Nanowires (2018)
  • Author(s): Takeshi Yanagida
  • Organizer: 4th E-MRS and MRS-J Bilateral Symposium
  • Int'l Joint Research / Invited
• [Presentation] Deformable Single Crystalline Metal Oxide Nanowires and Their Deformable Device Applications Metal Oxide Nanowires (2018)
  • Author(s): Takeshi Yanagida
  • Organizer: IMID2018
  • Int'l Joint Research / Invited
• [Presentation] Metal Oxide Nanowire Meets Internet of Things (IoT) (2018)
  • Author(s): Takeshi Yanagida
  • Organizer: STEMa 2018
  • Int'l Joint Research / Invited
• [Presentation] Impact of Flux Window Principle on Oxide Nanowires and Their Properties (2018)
  • Author(s): Takeshi Yanagida
  • Organizer: Nanowire Week 2018
  • Int'l Joint Research / Invited
• [Presentation] Integrated Molecule Recognition Sensor Electronics using Nanostructured Metal Oxides on Silicon (2018)
  • Author(s): Takeshi Yanagida
  • Organizer: VLSI-TSA
• [Presentation] 単結晶金属酸化物ナノワイヤの作製プロセスと物性評価 (2018)
  • Author(s): 柳田剛
  • Organizer: 第 28 回日本 MRS 年次大会
• [Presentation] 界面制御によるナノ構造・物性の創成と IoT 分子センサデバイスへの展開 (2018)
  • Author(s): 柳田剛
  • Organizer: 堀場製作所講演会
  • Invited
• [Presentation] 分子選択的な捕集・濃縮技術の開発 (2018)
  • Author(s): 柳田剛
  • Organizer: 進化を超える極微量物質の超迅速多項目センシングシステム eInSECT で実現する安心・安全・快適な社会、
  • Invited
• [Presentation] 堅牢な分子識別エレクトロニクスが拓く IoT 戦略 (2018)
  • Author(s): 柳田剛
  • Organizer: 日本工学アカデミー講演会「次世代マテリアルシステム」
  • Invited
• [Presentation] ナノワイヤを用いた尿中細胞外小胞体捕捉 (2018)
  • Author(s): 柳田剛
  • Organizer: 文科省ナノテクプラットフォーム講演会
  • Invited
• [Presentation] 金属酸化物ナノワイヤの IoT 戦略 (2018)
  • Author(s): 柳田剛
  • Organizer: 第 113 回テクノラボツアー講演会「新材料から IoT 応用まで―工学的ブレイクスルーと医工連携を目指し て―」
  • Invited
• [Presentation] 金属酸化物ナノワイヤ (2018)
  • Author(s): 柳田剛
  • Organizer: 日本表面真空学会 機能薄膜部会 ナノ構造機能創成専門部会 第９回研究会 ＜無機結晶のフレキシブルコ ーティングによる機能創成＞
  • Invited
• [Presentation] 酸化物ナノワイヤを用いたナノバイオデバイス (2018)
  • Author(s): 柳田剛
  • Organizer: 分子物質合成プラットフォームシンポジウム
  • Invited
• [Presentation] 「pMAIRS 法を用いた非平滑な単結晶ナノワイヤにおける分子配向解析と新しい分子認識集積化デバイス への展開」 (2018)
  • Author(s): 柳田剛
  • Organizer: サーモフィッシャーサイエンティフィック「FT-IR・ラマンユーザーズフォーラム
  • Invited
• [Book] 結晶成長の空間選択性に基づいた単結晶金属酸化物ナノワイヤの創製とナノデバイス展開” (2018)
  • Author(s): 柳田 剛, 長島一樹, 高橋綱己
  • Publisher: 応用物理
• [Book] 単結晶酸化物ナノワイヤの界面選択的結晶成長に基づく構造・組成・機能制御とデバイス展開 (2018)
  • Author(s): 長島一樹、高橋綱己、柳田 剛
  • Publisher: セラミックス