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Designing the mammalian biological oscillators

Research Project

Project/Area Number 18H05270
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Review Section Broad Section G
Research InstitutionThe University of Tokyo

Principal Investigator

Ueda Hiroki  東京大学, 大学院医学系研究科(医学部), 教授 (20373277)

Co-Investigator(Kenkyū-buntansha) 大出 晃士  東京大学, 大学院医学系研究科(医学部), 講師 (40612122)
清成 寛  国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (40721048)
山田 陸裕  国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (90469924)
史 蕭逸  東京大学, 大学院医学系研究科(医学部), 助教 (40803656)
洲崎 悦生  東京大学, 大学院医学系研究科(医学部), 准教授 (10444803)
Project Period (FY) 2018-06-11 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥200,330,000 (Direct Cost: ¥154,100,000、Indirect Cost: ¥46,230,000)
Fiscal Year 2022: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2021: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2020: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2019: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2018: ¥122,590,000 (Direct Cost: ¥94,300,000、Indirect Cost: ¥28,290,000)
Keywords可逆的リン酸化 / 振動子 / 概日時計 / CKI / 変異マウス作製
Outline of Final Research Achievements

Our group has shown that the activity of Casein kinase I (CKI) δ/ε, which phosphorylates the circadian core transcriptional repressor complex, plays a critical role in the determination of circadian period length. In this project, we focused on the fact that CKI δ/ε catalyzes not only phosphorylation but also a reverse dephosphorylation reaction with high efficiency, and asked whether the reversible phosphorylation cycle is important for the regulation of the mammalian circadian clock through analysis of the regulatory mechanism of CKI δ/ε dephosphorylation activity. We found the existence of phosphorylated substrate peptides that affect the dephosphorylation activity of CKIδ/ε through in vitro biochemical experiments. We further found that the protein region from which the substrate peptides are derived is important for the regulation of the circadian period length of the circadian clock through animal phenotypes.

Academic Significance and Societal Importance of the Research Achievements

CKIδ/εの脱リン酸化反応効率に影響を与えるリン酸化基質ペプチドが個体レベルでの行動リズム制御にも重要であることが示され、CKIδ/εの脱リン酸化活性が機能的な意義を有することが示唆された。哺乳類概日時計の発振を担うかもしれない、可逆的リン酸化サイクルの同定に向けた重要な一歩である。さらに、可逆的リン酸化数理モデルに由来するカオス構造の発見や、後天的な概日時計因子の発現によるマウス行動リズムの再構成系など、哺乳類概日時計の動作モデルを、旧来支配的であった転写翻訳ネットワークに基づく理解から、可逆的リン酸化モデルに基づく理解と制御に当該分野をシフトさせる基盤的な知見となると期待される。

Assessment Rating
Ex-post Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.

Assessment Rating
Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Report

(11 results)
  • 2023 Ex-post Assessment (Comments) ( PDF )
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Abstract (Interim Assessment) ( PDF )   Annual Research Report   Interim Assessment (Comments) ( PDF )
  • 2019 Annual Research Report
  • 2018 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (144 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (31 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 24 results,  Open Access: 15 results) Presentation (113 results) (of which Int'l Joint Research: 48 results,  Invited: 104 results)

  • [Journal Article] CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy2023

    • Author(s)
      Ishii Shunsuke、Chino Haruka、Ode Koji L.、Kurikawa Yoshitaka、Ueda Hiroki R.、Matsuura Akira、Mizushima Noboru、Itakura Eisuke
    • Journal Title

      Molecular Biology of the Cell

      Volume: 34 Issue: 4

    • DOI

      10.1091/mbc.e22-09-0432

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of calcium and CaMKII in sleep2022

    • Author(s)
      Wang Yuyang、Minami Yoichi、Ode Koji L.、Ueda Hiroki R.
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 16 Pages: 1059421-1059421

    • DOI

      10.3389/fnsys.2022.1059421

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep2022

    • Author(s)
      Daisuke Tone, Koji L Ode, Qianhui Zhang, Hiroshi Fujishima, Rikuhiro G Yamada, et al.
    • Journal Title

      PLOS Biology

      Volume: 20 Issue: 10 Pages: 3001813-3001813

    • DOI

      10.1371/journal.pbio.3001813

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ubiquitination of phosphatidylethanolamine in organellar membranes2022

    • Author(s)
      Sakamaki Jun-ichi、Ode Koji L.、Kurikawa Yoshitaka、Ueda Hiroki R.、Yamamoto Hayashi、Mizushima Noboru
    • Journal Title

      Molecular Cell

      Volume: 82 Issue: 19 Pages: 3677-3692.e11

    • DOI

      10.1016/j.molcel.2022.08.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis2022

    • Author(s)
      Takahashi K, Abe K, Kubota SI, Fukatsu N, Morishita Y, Yoshimatsu Y, Satoshi Hirakawa, Yoshiaki Kubota, Tetsuro Watabe, Shogo Ehata, Hiroki R. Ueda, Teppei Shimamura, Kohei Miyazono
    • Journal Title

      Nature Communiactions

      Volume: 13 Issue: 1 Pages: 5239-5239

    • DOI

      10.1038/s41467-022-32848-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins2022

    • Author(s)
      Chino Haruka、Yamasaki Akinori、Ode Koji L、Ueda Hiroki R、Noda Nobuo N、Mizushima Noboru
    • Journal Title

      EMBO reports

      Volume: - Issue: 6

    • DOI

      10.15252/embr.202254801

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 睡眠覚醒制御のタンパク質リン酸化仮説2022

    • Author(s)
      大出晃士, Zhiqing Wen, 上田泰己
    • Volume
      40
    • Pages
      1696
    • DOI

      10.18958/7031-00001-0000171-00

    • Related Report
      2022 Annual Research Report
  • [Journal Article] A jerk-based algorithm ACCEL for the accurate classification of sleep?wake states from arm acceleration2022

    • Author(s)
      Ode Koji L.、Shi Shoi、Katori Machiko、Mitsui Kentaro、Takanashi Shin、Oguchi Ryo、Aoki Daisuke、Ueda Hiroki R.
    • Journal Title

      iScience

      Volume: 25 Issue: 2 Pages: 103727-103727

    • DOI

      10.1016/j.isci.2021.103727

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A design principle of spindle oscillations in mammalian sleep2022

    • Author(s)
      Yamada Tetsuya、Shi Shoi、Ueda Hiroki R.
    • Journal Title

      iScience

      Volume: 25 Issue: 3 Pages: 103873-103873

    • DOI

      10.1016/j.isci.2022.103873

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes2022

    • Author(s)
      Katori Machiko、Shi Shoi、Ode Koji L.、Tomita Yasuhiro、Ueda Hiroki R.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 12

    • DOI

      10.1073/pnas.2116729119

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-throughput Genetically Modified Animal Experiments Achieved by Next-generation Mammalian Genetics2022

    • Author(s)
      Minami Yoichi、Yuan Yufei、Ueda Hiroki R.
    • Journal Title

      Journal of Biological Rhythms

      Volume: 37 Issue: 2 Pages: 135-151

    • DOI

      10.1177/07487304221075002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue clearing2021

    • Author(s)
      Richardson Douglas S.、Guan Webster、Matsumoto Katsuhiko、Pan Chenchen、Chung Kwanghun、Ert?rk Ali、Ueda Hiroki R.、Lichtman Jeff W.
    • Journal Title

      Nature Reviews Methods Primers

      Volume: 1 Issue: 1 Pages: 84-84

    • DOI

      10.1038/s43586-021-00080-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Towards organism-level systems biology by next-generation genetics and whole-organ cell profiling2021

    • Author(s)
      Minami Yoichi、Yuan Yufei、Ueda Hiroki R.
    • Journal Title

      Biophysical Reviews

      Volume: 13 Issue: 6 Pages: 1113-1126

    • DOI

      10.1007/s12551-021-00859-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A design principle for posttranslational chaotic oscillators2021

    • Author(s)
      Yamaguchi Hiroto Q.、Ode Koji L.、Ueda Hiroki R.
    • Journal Title

      iScience

      Volume: 24 Issue: 1 Pages: 101946-101946

    • DOI

      10.1016/j.isci.2020.101946

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues2020

    • Author(s)
      Susaki Etsuo A.、Shimizu Chika、Kuno Akihiro、Tainaka Kazuki、Li Xiang、Shibayama Mitsuhiro、Ueda Hiroki R. et al.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1982-1982

    • DOI

      10.1038/s41467-020-15906-5

    • NAID

      120006956725

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-Brain Profiling of Cells and Circuits in Mammals by Tissue Clearing and Light-Sheet Microscopy2020

    • Author(s)
      Ueda Hiroki R.、Dodt Hans-Ulrich、Osten Pavel、Economo Michael N.、Chandrashekar Jayaram、Keller Philipp J.
    • Journal Title

      Neuron

      Volume: 106 Issue: 3 Pages: 369-387

    • DOI

      10.1016/j.neuron.2020.03.004

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation Hypothesis of Sleep2020

    • Author(s)
      Ode Koji L.、Ueda Hiroki R.
    • Journal Title

      Frontiers in Psychology

      Volume: 11 Pages: 575328-575328

    • DOI

      10.3389/fpsyg.2020.575328

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocol for Imaging and Analysis of Mouse Tumor Models with CUBIC Tissue Clearing2020

    • Author(s)
      Takahashi Kei, Kubota Shimpei I., Ehata Shogo, Ueda Hiroki R., Miyazono Kohei
    • Journal Title

      STAR Protocols

      Volume: 1 Issue: 3 Pages: 100191-100191

    • DOI

      10.1016/j.xpro.2020.100191

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Mechanisms of REM Sleep2020

    • Author(s)
      Yamada Rikuhiro G.、Ueda Hiroki R.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13

    • DOI

      10.3389/fnins.2019.01402

    • NAID

      40022400341

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization and molecular characterization of whole-brain vascular networks with capillary resolution.2020

    • Author(s)
      Takeyuki Miyawaki,Shota Morikawa,Etsuo A Susaki,Ai Nakashima,Haruki Takeuchi,Shun Yamaguchi,Hiroki R Ueda,Yuji Ikegaya
    • Journal Title

      Nature communications

      Volume: 11 Issue: 1 Pages: 1104-1104

    • DOI

      10.1038/s41467-020-14786-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue clearing and its applications in?neuroscience2020

    • Author(s)
      Ueda Hiroki R.、Ert?rk Ali、Chung Kwanghun、Gradinaru Viviana、Ch?dotal Alain、Tomancak Pavel、Keller Philipp J.
    • Journal Title

      Nature Reviews Neuroscience

      Volume: 21 Issue: 2 Pages: 61-79

    • DOI

      10.1038/s41583-019-0250-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 増大特集 人工知能と神経科学 病理画像の自動診断技術と3次元病理学の発展2019

    • Author(s)
      洲﨑 悦生
    • Journal Title

      BRAIN and NERVE

      Volume: 71 Issue: 7 Pages: 723-732

    • DOI

      10.11477/mf.1416201344

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2019-07-01
    • Related Report
      2019 Annual Research Report
  • [Journal Article] CUBICを用いた組織透明化と3次元観察2019

    • Author(s)
      洲崎 悦生
    • Journal Title

      和光純薬時報

      Volume: 87 Pages: 16-19

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 透明イメージングの臨床応用 組織透明化技術と細胞ラベリング技術2019

    • Author(s)
      洲崎 悦生
    • Journal Title

      月刊メディカル・サイエンス・ダイジェスト

      Volume: 45 Pages: 390-393

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 概日時計と睡眠2019

    • Author(s)
      大出 晃士、上田 泰己
    • Journal Title

      臨床神経科学

      Volume: 37 Pages: 770-773

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Next-generation human genetics for organism-level systems biology2019

    • Author(s)
      Ukai Hideki、Sumiyama Kenta、Ueda Hiroki R
    • Journal Title

      Current Opinion in Biotechnology

      Volume: 58 Pages: 137-145

    • DOI

      10.1016/j.copbio.2019.03.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A period without PER: understanding 24-hour rhythms without classic transcription and translation feedback loops2019

    • Author(s)
      Millius Arthur、Ode Koji L.、Ueda Hiroki R.
    • Journal Title

      F1000Research

      Volume: 8 Pages: 499-499

    • DOI

      10.12688/f1000research.18158.1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 哺乳類概日時計の周期長決定要因を探る2019

    • Author(s)
      大出 晃士, 上田 泰己
    • Journal Title

      実験医学

      Volume: 37 Pages: 379-385

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.2018

    • Author(s)
      Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
    • Journal Title

      Cell Rep.

      Volume: 24 Issue: 8 Pages: 2196-2210

    • DOI

      10.1016/j.celrep.2018.07.056

    • NAID

      120006542018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy.2018

    • Author(s)
      Mano T, Albanese A, Dodt HU, Erturk A, Gradinaru V, Treweek JB, Miyawaki A, Chung K, Ueda HR.
    • Journal Title

      J. Neurosci.

      Volume: 38 Issue: 44 Pages: 9330-9337

    • DOI

      10.1523/jneurosci.1677-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CUBICによる全脳全細胞解析最前線2018

    • Author(s)
      真野智之, 上田泰己
    • Journal Title

      実験医学増刊

      Volume: 36 Pages: 150-157

    • Related Report
      2018 Annual Research Report
  • [Presentation] Towards Systems Biology of Human Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep2023

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 睡眠医学の現在と未来 ~睡眠健診の実現に向けて~2023

    • Author(s)
      上田 泰己
    • Organizer
      兵庫県バイオ技術研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] システム医学の実現に向けて~睡眠科学を例に~2023

    • Author(s)
      上田 泰己
    • Organizer
      第6回日本免疫不全・自己炎症学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 全身全細胞解析の実現にむけて2023

    • Author(s)
      上田 泰己
    • Organizer
      第39回日本毒性病理学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Whole-body/organ imaging with single-cell resolution by CUBIC2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      2nd optical clearing and expansion symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution for Mammalian Synthetic Biology2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      第45回 日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 全身全細胞解析の実現に向けて2022

    • Author(s)
      上田 泰己
    • Organizer
      日本薬物動態学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ヒト睡眠・覚醒リズム研究の現在と未来~睡眠のリン酸化仮説から睡眠健診まで~2022

    • Author(s)
      上田 泰己
    • Organizer
      日本臨床睡眠医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Towards Systems Biology of Human Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      KSBB Circadian Rhythm and Human Health" Session
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Realization of the Phosphorylation Hypothesis of Sleep by CaMKII2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      SLEEP EUROPE 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Systems biology of mammalian sleep/wake cycles: phosphorylation hypothesis of sleep2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      SLEEP EUROPE 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒトシステム生物学の実現に向けて~睡眠のリン酸化仮説~2022

    • Author(s)
      上田 泰己
    • Organizer
      メタボロームシンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Systems biology of mammalian sleep/wake cycles: phosphorylation hypothesis of sleep2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      The 20 th Sapporo Symposium on Biological Rhythm in 2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Phosphorylation hypothesis of sleep2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      EBRS 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 睡眠医学の現在と未来~睡眠健診の実現に向けて~2022

    • Author(s)
      上田 泰己
    • Organizer
      日本睡眠学会第47回定期学術集会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] システム医学の実現に向けて~睡眠科学を例に~2022

    • Author(s)
      上田 泰己
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] システム医学の実現に向けて~睡眠科学を例に~2022

    • Author(s)
      上田 泰己
    • Organizer
      第123回日本外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles:Phosphorylation Hypothesis of Sleep2022

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      Nano LSI Symposium
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] システム医学の実現に向けて~睡眠科学を例に~2022

    • Author(s)
      上田泰己
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles ~Phosphorylation Hypothesis of Sleep~2021

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      Biology Seminar at New York University Abu Dhabi (NYUAD)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 全身全細胞解析の実現にむけて2021

    • Author(s)
      上田泰己
    • Organizer
      第2回Seeing What’s Next<次世代の可視化技術勉強会> 先端医療開発センター
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Systems biology of mammalian sleep/wake cycles - phosphorylation hypothesis of sleep2021

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      KSBNS 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトシステム生物学の実現に向けて―睡眠のリン酸化仮説―2021

    • Author(s)
      上田泰己
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution by CUBIC2021

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      International Tissue Imaging Symposium Online
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep2021

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      5th Asian Forum on Chronobiology & 2021 ChronoSchool
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles ~Phosphorylation Hypothesis of Sleep~2021

    • Author(s)
      上田泰己
    • Organizer
      藤原セミナー・新学術領域「個性創発脳」国際シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 眠・覚醒リズムのシステム生物学~睡眠のリン酸化仮説~2021

    • Author(s)
      上田泰己
    • Organizer
      日本睡眠学会第46回学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] システム医学の実現に向けて~睡眠科学を例に~2021

    • Author(s)
      上田泰己
    • Organizer
      第74回日本自律神経学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution by CUBIC2021

    • Author(s)
      Hiroki R. Ueda
    • Organizer
      Insern Workshop 264
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep2021

    • Author(s)
      上田泰己
    • Organizer
      第44回日本分子生物学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 全身全細胞解析の実現にむけて2021

    • Author(s)
      上田泰己
    • Organizer
      第4回医薬品毒性機序研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 定量プロテオミクス分析設計の基礎と実際2021

    • Author(s)
      大出晃士
    • Organizer
      JKiCセミナー 第6回質量分析講習会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ウェアラブルデバイスを用いた簡易睡眠測定によるヒト睡眠ランドスケープの構築2021

    • Author(s)
      史蕭逸
    • Organizer
      日本睡眠学会第 46 回定期学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles: The Roles of Muscarinic Acetylcholine Receptor in NREM and REM Sleep.2021

    • Author(s)
      上田泰己
    • Organizer
      CINP2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution by CUBIC.2021

    • Author(s)
      上田泰己
    • Organizer
      FOM2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CUBIC-HistoVIsion: a versatile three-dimensional whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissue (Keynote talk)?2021

    • Author(s)
      洲崎悦生
    • Organizer
      Volume Imaging Symposium (VIS) 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] セルオミクスによる細胞ネットワークの定量的解析?2021

    • Author(s)
      洲崎悦生
    • Organizer
      第5回理論免疫学ワークショップ?
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 睡眠・覚醒リズムのシステム生物学:睡眠のリン酸化仮説2020

    • Author(s)
      上田泰己
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 体内時計と睡眠の分子生物学2020

    • Author(s)
      上田泰己
    • Organizer
      第93回日本生化学大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Phosphorylation hypothesis of sleep2020

    • Author(s)
      上田泰己
    • Organizer
      ESRS2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] WHOLE-BODY/ORGAN IMAGING WITH SINGLE-CELL RESOLUTION BY CUBIC2020

    • Author(s)
      上田泰己
    • Organizer
      SFM2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-Brain Profiling of Cells and Circuits by a Tissue-Clearing Method CUBIC.2020

    • Author(s)
      上田泰己
    • Organizer
      INA2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake ~Cycles Phosphorylation Hypothesis of Sleep~2020

    • Author(s)
      上田泰己
    • Organizer
      The 4th Symposium of the Inter-University Research Network for Trans-Omics Medicine Trans-Omics for Advanced Medical Sciences
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 多重リン酸化を基盤とした時間情報制御2020

    • Author(s)
      大出晃士
    • Organizer
      第27回日本時間生物学会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 多細胞システムの理解に向けた セルオミクス技術の開発と応用2020

    • Author(s)
      洲崎悦生
    • Organizer
      第3回 ExCELLSシンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] CUBIC-HistoVIsion: a versatile three-dimensional whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissue2020

    • Author(s)
      洲崎悦生
    • Organizer
      4th NanoLSI Symposium
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 多細胞システムの理解に向けたセルオミクス技術の開発と応用?2020

    • Author(s)
      洲崎悦生
    • Organizer
      Cell Biology, Developmental Biology, and Systems Biology course meeting
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] セルオミクス技術の開発と医学生物学応用?2020

    • Author(s)
      洲崎悦生
    • Organizer
      2020年日本バイオインフォマティクス学会年会 第9回生命医薬情報学連合大会2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution by CUBIC2020

    • Author(s)
      上田泰己
    • Organizer
      2020 SYNAPSE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] セルオミクスによる多細胞システム解明へのアプローチ2020

    • Author(s)
      洲崎悦生
    • Organizer
      岡山大学次世代研究拠点シンポジウム2020「口腔器官の再構築から器官の発生・再生の統一原理の解明」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Identification of sleep genes by mathematical model and mouse genetics2020

    • Author(s)
      史蕭逸
    • Organizer
      第2回 Synchronization phenomena on complex networks, from math to experiments
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles Toward Molecular definition of NREM and REM sleeps2019

    • Author(s)
      上田泰己
    • Organizer
      CIBR Beijing Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organism-level Systems Biology by Next-generation Genetics and Whole-organ Cell Profiling2019

    • Author(s)
      上田泰己
    • Organizer
      The 5th Conference of the World Congress for Chronobiology (WCC)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-Brain Cell Profiling Towards Organism-Level Synthetic Biology2019

    • Author(s)
      上田泰己
    • Organizer
      Gordon Research Conference (Synthetic Biology)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-Brain Cell Profiling Towards Organism-Level Synthetic Biology2019

    • Author(s)
      上田泰己
    • Organizer
      Exploring Frontiers (Paul Allen Institute)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles ~Phosphorylation Hypothesis of Sleep~2019

    • Author(s)
      上田泰己
    • Organizer
      EBRS2019(Europian Biologocal Rhyhms conferrence)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organism-level Systems Biology by Next-generation Genetics and Whole-organ Cell Profiling2019

    • Author(s)
      上田泰己
    • Organizer
      10th IBRO World Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Towards Organism-level Systems Biology by Next-generation Genetics and Whole-organ Cell Profiling2019

    • Author(s)
      上田泰己
    • Organizer
      The 2019 Conference of The Genetics Society of Korea
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Towards organism-level systems biology by next-generation genetics and whole-organ cell profiling2019

    • Author(s)
      上田泰己
    • Organizer
      16th International Symposium on Cholinergic Mechanisms and 2nd MISRAHI SYMPOSIUM ON NEUROBIOLOGY
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A versatile three-dimensional whole-organ/body staining and imaging with single-cell resolution based on electrolyte-gel properties of biological tissue2019

    • Author(s)
      洲崎悦生
    • Organizer
      The Light Sheet Microscopy Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Newly-identified sleep genes: The role of calcium dependent hyperpolarization pathway in sleep regulation2019

    • Author(s)
      史蕭逸
    • Organizer
      World Sleep 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「全身全細胞解析の実現にむけて」2019

    • Author(s)
      上田泰己
    • Organizer
      第107回 日本泌尿器科学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「組織透明化技術「CUBIC」のヒト病理組織診断への応用 」2019

    • Author(s)
      上田泰己
    • Organizer
      第108回 日本病理学会 スイーツセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「全身透明化の先に見えるもの~死因解明への応用に向けて~」2019

    • Author(s)
      上田泰己
    • Organizer
      死因研究シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「全脳全細胞解析の実現にむけて」2019

    • Author(s)
      上田泰己
    • Organizer
      第35回電子顕微鏡技術学会学術講演会の ワークショップ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles Toward Molecular definition of NREM and REM sleeps2019

    • Author(s)
      上田泰己
    • Organizer
      第42回 日本神経科学大会 (Neuro 2019)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「全身全細胞解析の実現にむけて」2019

    • Author(s)
      上田泰己
    • Organizer
      第7回 がんと代謝研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「全身全細胞解析の実現に向けて」2019

    • Author(s)
      上田泰己
    • Organizer
      第51回 日本臨床分子形態学会 総会・学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake ~Cycles Phosphorylation Hypothesis of Sleep~2019

    • Author(s)
      上田泰己
    • Organizer
      The 4th Symposium of the Inter-University Research Network for Trans-Omics Medicine Trans-Omics for Advanced Medical Sciences
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution Toward Organism-level Systems Biology2019

    • Author(s)
      上田泰己
    • Organizer
      3rd QST International Symposium "Quantum Life Science",2019,2019,1,0
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 組織透明化技術の開発と医学生物学応用2019

    • Author(s)
      洲崎悦生
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 全臓器・全身スケールの多階層空間オミクス実現に向けたアプローチ2019

    • Author(s)
      洲崎悦生
    • Organizer
      シングルセルゲノミクス研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 哺乳類CaMKIIの酵素活性依存的な睡眠時間長制御2019

    • Author(s)
      大出晃士
    • Organizer
      第26回日本時間生物学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Residue-level characterization of mCRY1-dependent circadian control2019

    • Author(s)
      大出晃士
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 睡眠時間長制御因子としての哺乳類CaMKII活性2019

    • Author(s)
      大出晃士
    • Organizer
      日本睡眠学会第44回定期学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Understanding the role of Ca2+-dependent hyperpolarization pathway in sleep homeostasis2019

    • Author(s)
      史蕭逸
    • Organizer
      第42回 日本神経科学大会 (Neuro 2019)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A versatile protocol for three-dimensional whole-organ/body staining and imaging with single-cell resolution based on electrolyte-gel properties of biological tissue2019

    • Author(s)
      洲崎悦生
    • Organizer
      Society for Neuroscience conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ca2+-dependent/-independent hyperpolarization pathway plays a role in sleep regulation -the first application of cubic in sleep research-2019

    • Author(s)
      史蕭逸
    • Organizer
      Society for Neuroscience conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles Toward Molecular definition of NREM and REM sleeps2019

    • Author(s)
      上田泰己
    • Organizer
      ASCS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organism-level Systems Biology by Next-generation Genetics and Whole-organ Cell Profiling2019

    • Author(s)
      上田泰己
    • Organizer
      名古屋大学グローバルリトリート2019
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles Toward Molecular definition of NREM and REM sleep2019

    • Author(s)
      上田泰己
    • Organizer
      International Symposium on Biological RhythmsThe symposium on "Biological Timing and Health Issues in the 21st Century",
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Towards Organism-Level Systems Biology by Next-Generation Genetics and Whole-Organ Cell Profiling2019

    • Author(s)
      上田泰己
    • Organizer
      HKIAS Symposium on Advances in Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles Toward Molecular definition of NREM and REM sleeps2019

    • Author(s)
      上田泰己
    • Organizer
      The 17th Annual Meeting of Taiwan Society of Sleep Medicine (TSSM) in conjunction with the 2nd Conference of Asian Narcolepsy & Hypersomnolence Society (ANHS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-organ/body analysis of multicellular systems by CUBIC platform2019

    • Author(s)
      洲崎悦生
    • Organizer
      Single cell biology meets diagnostics: 12th International workshop on approaches to single cell analysis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Comprehensive Analysis of Neural Activity in Lipopolysaccharide-induced Sleep by Whole-brain Imaging2019

    • Author(s)
      Kazuhiro Kon, Tomoyuki Mano, Etsuo A. Susaki, and Hiroki R. Ueda
    • Organizer
      Neuroimmune Communication in Health and Disease (Gordon Research Conference)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 次世代遺伝学による睡眠表現型解析2019

    • Author(s)
      山田陸裕
    • Organizer
      理研実験動物ネットワーク会議
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Towards Organism-level Systems Biology2018

    • Author(s)
      上田泰己
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution Toward Organism-level Systems Biology2018

    • Author(s)
      上田泰己
    • Organizer
      7th Conference on Systems Biology of Mammalian Cells SBMC2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「睡眠覚醒におけるカルシウム依存的過分極機構の役割」2018

    • Author(s)
      上田泰己
    • Organizer
      第43回日本睡眠学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution: Toward Organism -level Systems Biology2018

    • Author(s)
      上田泰己
    • Organizer
      Asian Forum on Chronobiology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organism-level Systems Biology by Whole-organ Cell Profiling and Next-generation Mammalian Genetics2018

    • Author(s)
      上田泰己
    • Organizer
      Biomedical research Council's Distinguished Visitor Program
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 個体レベルのシステム生物学の実現に向けて―体内の「時間」を理解する―2018

    • Author(s)
      上田泰己
    • Organizer
      質量分析フォーラム2018 大阪会場
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Systems Biology of Mammalian Sleep/wake Cycles ~Involvement of Ca2+-DependentHyperpolarization in Sleep Duration in Mammals2018

    • Author(s)
      上田泰己
    • Organizer
      第41回本神経科学学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 個体レベルのシステム生物学の実現に向けて―体内の「時間」を理解する―2018

    • Author(s)
      上田泰己
    • Organizer
      質量分析フォーラム2018 東京会場
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Whole-body/organ Imaging with Single-cell Resolution Toward Organism-level Systems Biology2018

    • Author(s)
      上田泰己
    • Organizer
      LSFM2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Whole-body/organ imaging with single-cell resolution toward organism-level systems biology2018

    • Author(s)
      上田泰己
    • Organizer
      KBRI Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Circadian Clocks2018

    • Author(s)
      上田泰己
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 眠覚醒におけるカルシウム依存的過分極機構の役割2018

    • Author(s)
      上田泰己
    • Organizer
      第37回日本認知症学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] “Systems Biology of Mammalian Sleep/Wake Cycles -Toward Molecular definition of Non-REM and REM sleeps-”2018

    • Author(s)
      上田泰己
    • Organizer
      The 3rd Japan-US Science Forum in Boston
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Towardssystem-level understanding of biological timing2018

    • Author(s)
      上田泰己
    • Organizer
      IMB Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systems Biology of Mammalian Sleep/Wake Cycles Toward Molecular definition of NREM and REM sleeps2018

    • Author(s)
      上田泰己
    • Organizer
      The 3rd cBio
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多細胞システムの状態定義・分離を目指す技術開発2018

    • Author(s)
      洲崎悦生
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] CUBIC-HistoVIsion: a pipeline for three-dimentional whole-brain/organ staining and imaging with single-cell resolution2018

    • Author(s)
      洲崎悦生
    • Organizer
      ECRO 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多細胞システムの理解に向けた要素技術開発と展望2018

    • Author(s)
      洲崎悦生
    • Organizer
      第58回 生命科学夏の学校
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 網羅的細胞観察・解析技術による、多細胞システム解明への挑戦2018

    • Author(s)
      洲崎悦生
    • Organizer
      第5回包括的緩和医療科学学術研究会/第6回Tokyo疼痛緩和次世代研究会 合同研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Tissue clearing and 3D imaging: basics and applications2018

    • Author(s)
      洲崎悦生
    • Organizer
      EMBO practical course on light sheet microscopy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CUBIC-HistoVIsion: a pipeline for 3D whole-organ/body staining and imaging with single-cell resolution based on chemical properties of tissue gel2018

    • Author(s)
      洲崎悦生
    • Organizer
      SBIC seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 概日リズムを駆動する時計タンパク質の量的変動と質的変動2018

    • Author(s)
      大出晃士
    • Organizer
      The 45th Biological Mass Spectrometry Conference
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Structure-guided engineering of mCRY1 to elucidate the protein quality control for the determination of circadian clock speed2018

    • Author(s)
      大出晃士
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Structure-guided engineering of mammalian Cryptochrome to elucidate the origin of 24-hour period2018

    • Author(s)
      大出晃士
    • Organizer
      第25回日本時間生物学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] CUBIC-Cloud: A point-cloud-based computational framework to analyze, visualize and share data for whole brain profiling by tissue clearing2018

    • Author(s)
      真野智之、上田泰己
    • Organizer
      Society for Neuroscience
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Impairments of Ca2+-dependent Hyperpolarization Pathway Altered NREM Sleep Duration in Mice2018

    • Author(s)
      Kazuhiro Kon, Shoi Shi, and Hiroki R. Ueda
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pharmacological analysis of sleep/wake consolidation mechanisms in mammals2018

    • Author(s)
      Qianhui ZHANG, Hiroki R. Ueda
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2018 Annual Research Report

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Published: 2018-06-12   Modified: 2024-03-28  

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