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Self-renewal capacity of hematopoietic stem cells and mitochondrial metabolism

Research Project

Project/Area Number 18H05284
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Review Section Broad Section I
Research InstitutionKumamoto University

Principal Investigator

須田 年生  熊本大学, 国際先端医学研究機構, 卓越教授 (60118453)

Co-Investigator(Kenkyū-buntansha) 馬場 理也  熊本大学, 国際先端医学研究機構, 准教授 (10347304)
梅本 晃正  熊本大学, 国際先端医学研究機構, 特任准教授 (50620225)
Project Period (FY) 2018-06-11 – 2023-03-31
Project Status Granted (Fiscal Year 2022)
Budget Amount *help
¥182,000,000 (Direct Cost: ¥140,000,000、Indirect Cost: ¥42,000,000)
Fiscal Year 2022: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2021: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2020: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2019: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Fiscal Year 2018: ¥36,400,000 (Direct Cost: ¥28,000,000、Indirect Cost: ¥8,400,000)
Keywords造血幹細胞 / 造血微小環境(ニッチ) / 不均等分裂 / 自己複製 / ミトコンドリア / 造血微小循環(ニッチ) / 造血微小環境(ニッチ)
Outline of Annual Research Achievements

造血幹細胞の分化・増殖により生体の成熟血球が供給される。健常な造血において、骨髄造血幹細胞はストレス造血時などに備え、自己複製能を保持し細胞周期静止期状態で維持されている。本研究では、幹細胞・巨核球の産生において最重要なサイトカイン、トロンボポエチン (Thpo)がThpoシグナルがどのようにミトコンドリアー小胞体(ER)代謝を制御し、造血幹細胞の分化・維持に関わるのか、その分子メカニズムの詳細を明らかにしてきた。
引き続き、Tumor suppressor geneであるFolliculin (Flcn) KO mouse(研究分担者;馬場理也)とミトコンドリア膜結合分子(MAM)の一つであるMitol KOマウスを用いて、造血幹細胞におけるミトコンドリア代謝・ライソソーム機能を解析する。更には、「造血発生過程の解析からの造血幹細胞の誘導」に挑戦する。 さらに、最近得た胎児肝臓における造血幹細胞の研究成果(後述)をもとに、幹細胞の自己複製培養を開発する。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

造血幹細胞研究において、自己複製と分化がどのように選択されているかは、中心課題である。我々は、「マウス胎児肝臓造血幹細胞はもっぱら自己複製過程をする」という仮説のもとに研究を進めた。胎生8-9日に、背側大動脈のhemogenic endothelial cellから造血細胞が出現する(Takakura N, Immunity, 1998)。 我々の研究により、マウス胎児では、造血性血管内皮細胞(EHC)から造血幹細胞の出現とほぼ同時期に、赤芽球骨髄球前駆細胞(EMP; Erythro-Myeloid Progenitor)が検出されることが明らかとなっている。
今回、造血幹細胞とEMP、これら2つの細胞系譜は分離され、胎児肝においては、HSCは、もっぱら自己複製をし、分化には寄与しない、一方、成熟細胞は、前駆細胞から供給されるということを、造血幹細胞特異的に発現する遺伝子Hepatic Leukemic Factor, Hlfレポーターマウス(Hlf-tdTomatoマウス)を作製して明らかにした。また、この幹細胞の自己複製は、Evi-1転写因子の発現量に比利することを明らかにした。
これらのデータは、幹細胞の自己複製に関するきわめて重要な所見・コンセプトで、Nature 誌に投稿され、Minor reviseが終わり、Acceptを待っている段階である。
Yokomizo T, Ideue, T, Sato T, Takeda N,Kurokawa M, Komatsu N, Araki, K, Osato M, Suda T: Tracing the origin of hierarchical hematopoietic structure in fetal liver. Nature in minor revise.

Strategy for Future Research Activity

本年度は、このHSC-independent pathway の解析をさらに進め、幹細胞を幹細胞のまま維持、増幅する培養法を確立する。また、ESなどの多能性幹細胞からの幹細胞誘導への応用を図る。関連論文は数編見られるものの、いずれも造血幹細胞特異的な誘導とはいえず、その頻度は低く、未だ確定した定法はないと考えている。

Assessment Rating
Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Report

(8 results)
  • 2021 Annual Research Report
  • 2020 Abstract (Interim Assessment) ( PDF )   Annual Research Report   Interim Assessment (Comments) ( PDF )
  • 2019 Annual Research Report
  • 2018 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report

Research Products

(54 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (35 results) (of which Int'l Joint Research: 35 results,  Peer Reviewed: 35 results,  Open Access: 24 results) Presentation (16 results) (of which Int'l Joint Research: 11 results,  Invited: 4 results)

  • [Int'l Joint Research] シンガポール国立大学(NUS)/がん科学研究所(CSI)(シンガポール)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] シンガポール国立大学(NUS)/がん科学研究所(CSI)(シンガポール)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] シンガポール国立大学(NUS)/がん科学研究所(CSI)(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration2022

    • Author(s)
      Umemoto Terumasa、Johansson Alban、Ahmad Shah Adil Ishtiyaq、Hashimoto Michihiro、Kubota Sho、Kikuchi Kenta、Odaka Haruki、Era Takumi、Kurotaki Daisuke、Sashida Goro、Suda Toshio
    • Journal Title

      The EMBO Journal

      Volume: 41 Pages: 1-20

    • DOI

      10.15252/embj.2021109463

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain2022

    • Author(s)
      Fukuda Masahiro、Matsumara Takayoshi、Suda Toshio、Hirase Hajime
    • Journal Title

      Neurophotonics

      Volume: 9 Pages: 021910-021910

    • DOI

      10.1117/1.nph.9.2.021910

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide?chlorambucil conjugate2022

    • Author(s)
      Funasaki Shintaro、Mehanna Sally、Ma Wenjuan、Nishizawa Hidekazu、Kamikubo Yasuhiko、Sugiyama Hiroshi、Ikeda Shuji、Motoshima Takanobu、Hasumi Hisashi、Linehan W. Marston、Schmidt Laura S.、Ricketts Chris、Suda Toshio、Oike Yuichi、Kamba Tomomi、Baba Masaya
    • Journal Title

      Cancer Sci

      Volume: n/a

    • DOI

      10.1111/cas.15364

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autophagy is dispensable for the maintenance of hematopoietic stem cells in neonates2021

    • Author(s)
      Hashimoto Michihiro、Umemoto Terumasa、Nakamura-Ishizu Ayako、Matsumura Takayoshi、Yokomizo Tomomasa、Sezaki Maiko、Takizawa Hitoshi、Suda Toshio
    • Journal Title

      Blood Advances

      Volume: 5 Pages: 1594-1604

    • DOI

      10.1182/bloodadvances.2020002410

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021

    • Author(s)
      Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
    • Journal Title

      Blood

      Volume: 137 Pages: 908-922

    • DOI

      10.1182/blood.2019001044

    • NAID

      40022770508

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prolonged maintenance of hematopoietic stem cells that escape from thrombopoietin deprivation2021

    • Author(s)
      Nakamura-Ishizu Ayako、Chin Desmond Wai Loon、Matsumura Takayoshi、Tan Darren Qiancheng、Mochizuki-Kashio Makiko、Jianwen Deng、Suda Toshio
    • Journal Title

      Blood

      Volume: 137 Pages: 2609-2620

    • DOI

      10.1182/blood.2020005517

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Myeloma cells self-promote migration by regulating TAB1-driven TIMP-1 expression in mesenchymal stem cells2021

    • Author(s)
      Rethnam Malini、Tan Darren Qiancheng、Suda Toshio
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 534 Pages: 843-848

    • DOI

      10.1016/j.bbrc.2020.10.093

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mitochondria transfer from early stages of erythroblasts to their macrophage niche via tunnelling nanotubes2021

    • Author(s)
      Yang C, Endoh M, Tan DQ, Nakamura-Ishizu A, Takihara Y, Matsumura T, Suda T.
    • Journal Title

      British Journal of Haematology

      Volume: 193 Pages: 1260-1274

    • DOI

      10.1111/bjh.17531

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism2021

    • Author(s)
      Mochizuki-Kashio Makiko、Shiozaki Hiroko、Suda Toshio、Nakamura-Ishizu Ayako
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Pages: 4627-4627

    • DOI

      10.3390/ijms22094627

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lymphoid-biased hematopoietic stem cells and myeloid-biased hematopoietic progenitor cells have radioprotection activity2021

    • Author(s)
      Zhang Shanshan、O’Neill Aled、Xie Miner、Wu Peng、Wang Xiaofang、Bai Haitao、Dong Fang、Wang Jinhong、Zhang Qingyun、Suda Toshio、Ema Hideo
    • Journal Title

      Blood Science

      Volume: 3 Pages: 113-121

    • DOI

      10.1097/bs9.0000000000000089

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss of METTL3 Attenuates BPDCN Response to PRMT5 Inhibition Via Interferon Signaling2021

    • Author(s)
      Rethnam Malini、Tan Darren Qiancheng、Tan Shi Hao、Ying Li、Yang Henry、Suda Toshio
    • Journal Title

      Blood

      Volume: 138 Pages: 1132-1132

    • DOI

      10.1182/blood-2021-146108

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity2020

    • Author(s)
      M. Endoh, M. Baba, T. Endoh, A. Hirayama, A. Nakamura-Ishizu, T. Umemoto, M. Hashimoto, K. Nagashima, T. Soga, M. Lang, L. S. Schmidt, W. M. Linehan, T. Suda
    • Journal Title

      Cell Reports

      Volume: 30 Pages: 1823-1834

    • DOI

      10.1016/j.celrep.2020.01.042

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia2020

    • Author(s)
      Matsumura Takayoshi、Nakamura-Ishizu Ayako、Muddineni Siva Sai Naga Anurag、Tan Darren Qiancheng、Wang Chelsia Qiuxia、Tokunaga Kenji、Tirado-Magallanes Roberto、Sian Stephanie、Benoukraf Touati、Okuda Tsukasa、Asou Norio、Matsuoka Masao、Osato Motomi、Suda Toshio
    • Journal Title

      Blood

      Volume: 136 Pages: 1919-1932

    • DOI

      10.1182/blood.2019004292

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential2020

    • Author(s)
      O'Neill Aled、Chin Desmond、Tan Darren、Abdul Majeed A Qilah Banu Bte、Nakamura-Ishizu Ayako、Suda Toshio
    • Journal Title

      Haematologica

      Volume: 0 Pages: 0-0

    • DOI

      10.3324/haematol.2019.241406

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low-dose X-rays leave scars on human hematopoietic stem and progenitor cells: the role of reactive oxygen species2020

    • Author(s)
      Yamashita Masayuki、Suda Toshio
    • Journal Title

      Haematologica

      Volume: 105 Pages: 1986-1988

    • DOI

      10.3324/haematol.2020.254292

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hematopoietic Stem Cell Metabolism during Development and Aging2020

    • Author(s)
      Nakamura-Ishizu Ayako、Ito Keisuke、Suda Toshio
    • Journal Title

      Developmental Cell

      Volume: 54 Pages: 239-255

    • DOI

      10.1016/j.devcel.2020.06.029

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails2020

    • Author(s)
      Nakamura-Ishizu Ayako、Ahmad Shah Adil Ishtiyaq、Suda Toshio
    • Journal Title

      Trends in Cell Biology

      Volume: 30 Pages: 835-836

    • DOI

      10.1016/j.tcb.2020.08.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal2020

    • Author(s)
      Arai Fumio、Stumpf Patrick S.、Ikushima Yoshiko M.、Hosokawa Kentaro、Roch Aline、Lutolf Matthias P.、Suda Toshio、MacArthur Ben D.
    • Journal Title

      Cell Systems

      Volume: 11 Pages: 640-652

    • DOI

      10.1016/j.cels.2020.11.004

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] TUBB1 dysfunction identified in familial platelet disorder causes impaired proplatelet formation and genome instability2020

    • Author(s)
      Matsumura T, Nakamura-Ishizu A, Maki H, Takaoka K, Muddineni SSNA, Wang CQ, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M, Suda T
    • Journal Title

      Developmental Biology,

      Volume: 0 Pages: 0-0

    • DOI

      10.1111/bjh.15835

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modification of the bone marrow MSC population in a xenograft model of early multiple myeloma2019

    • Author(s)
      Berlier Jessica L.、Rethnam Malini、Banu Binte Abdul Majeed A'Qilah、Suda Toshio
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 508 Pages: 1175-1181

    • DOI

      10.1016/j.bbrc.2018.11.178

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sphingosine-1-phosphate signaling modulates terminal erythroid differentiation through the regulation of mitophagy2019

    • Author(s)
      Yang Chong、Hashimoto Michihiro、Lin Quy Xiao Xuan、Tan Darren Qiancheng、Suda Toshio
    • Journal Title

      Experimental Hematology

      Volume: 72

    • DOI

      10.1016/j.exphem.2019.01.004

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamic changes in the niche - N-cadherin revisited: the HSC “Niche Herein”2019

    • Author(s)
      Nakamura-Ishizu A, Suda T
    • Journal Title

      Cell Stem Cell

      Volume: 24(3) Pages: 355-356

    • DOI

      10.1016/j.stem.2019.02.007

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation2019

    • Author(s)
      Nakamura‐Ishizu Ayako、Suda Toshio
    • Journal Title

      Annals of the New York Academy of Sciences

      Volume: ー Pages: 1-8

    • DOI

      10.1111/nyas.14169

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease.2019

    • Author(s)
      Baba M, Furuya M, Motoshima T, Nagashima Y, Schmidt LS, Linehan WM, et al.
    • Journal Title

      Mol Cancer Res

      Volume: 印刷中 Pages: 1613-1626

    • DOI

      10.1158/1541-7786.mcr-18-1235

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.,2019

    • Author(s)
      Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku, Akihiko Shimono, Hitoshi Takizawa, Naomi Nakagata, Seiichi Mori, Mineo Kurokawa, Daniel Tenen, Motomi Osato, Toshio Suda, and Norio Komatsu.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 216 Pages: 1599-1614

    • DOI

      10.1084/jem.20181399

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High Mitochondrial Mass Is Associated With Reconstitution Capacity and Quiescence of Hematopoietic Stem Cells2019

    • Author(s)
      Yuji Takihara, Ayako Nakamura-Ishizu, Darren Qiancheng Tan, Masahiro Fukuda, Takayoshi Matsumura, Mitsuhiro Endoh, Yuichiro Arima, Desmond Wai Loon Chin, Terumasa Umemoto, Michihiro Hashimoto, Hidenobu Mizuno, Toshio Suda
    • Journal Title

      Blood Advances

      Volume: 3 Pages: 2323-2327

    • DOI

      10.1182/bloodadvances.2019032169

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Beginning of a New Era: Mapping the Bone Marrow Niche2019

    • Author(s)
      Nakamura-Ishizu Ayako、MacArthur Ben D.、Suda Toshio
    • Journal Title

      Cell

      Volume: 177 Pages: 1679-1681

    • DOI

      10.1016/j.cell.2019.05.042

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice2019

    • Author(s)
      Nakajima K, Ono M, Radovic U, Dizdarevic S, Tomizawa SI, Kuroha K, Nagamatsu G, Hoshi I, Matsunaga R, Shirakawa T, Kurosawa T, Miyazaki Y, Seki M, Suzuki Y, Koseki H, Nakamura M, Suda T, Ohbo K.
    • Journal Title

      Disease Models & Mechanisms

      Volume: 12 Pages: 1-13

    • DOI

      10.1242/dmm.040139

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells.2019

    • Author(s)
      Tan DQ, Li Y, Yang C, Li J, Tan SH, Chin DWL, Nakamura-Ishizu A, Yang H, Suda T
    • Journal Title

      Cell Rep.

      Volume: 26(9) Pages: 2316-2328

    • DOI

      10.1016/j.celrep.2019.02.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hlf expression marks the developmental pathway for hematopoietic stem cells but not for erythroid-myeloid progenitors2019

    • Author(s)
      Yokomizo T, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Koga S, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Ogawa M, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M,Suda T, Komatsu N
    • Journal Title

      J Exp. Med.

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Small Maf functions in the maintenance of germline stem cells in the Drosophila testis2018

    • Author(s)
      Tan Sharon Wui Sing、Yip George W.、Suda Toshio、Baeg Gyeong Hun
    • Journal Title

      Redox Biol.

      Volume: 15 Pages: 125-134

    • DOI

      10.1016/j.redox.2017.12.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyperactivated mitophagy in hematopoietic stem cells2018

    • Author(s)
      Yang Chong、Suda Toshio
    • Journal Title

      Nat Immunol.

      Volume: 19 Pages: 2-3

    • DOI

      10.1038/s41590-017-0008-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ca(2+)-mitochondria axis drives cell division in hematopoietic stem cells2018

    • Author(s)
      Umemoto T, Hashimoto M, MatsumuraT, Nakamura-Ishizu A, Suda T
    • Journal Title

      J Exp Med

      Volume: 218(8) Pages: 2097-2113

    • DOI

      10.1084/jem.20180421

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation2018

    • Author(s)
      Masaya Baba, Mitsuhiro Endoh. Wenjuan Ma, Hirofumi Toyama. Akiyoshi Hirayama, Keiyo Takubo, Hiroyuki Hano. Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 33 Issue: 10 Pages: 1785-1798

    • DOI

      10.1002/jbmr.3477

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thrombopoietin metabolically primes hematopoietic stem cells to megakaryocyte lineage differentiation2018

    • Author(s)
      Nakamura-Ishizu N, Matsumura T, Stumpf PS, Umemoto T, Takizawa H, Takihara Y, O’Neil A, Majeed ABBA, MacArthur BD., Suda T
    • Journal Title

      Cell Reports

      Volume: 25(7) Pages: 1772-1785

    • DOI

      10.1016/j.celrep.2018.10.059

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Mitochondrial metabolism and transfer in hematopoiesis2021

    • Author(s)
      Toshio Suda
    • Organizer
      JSPS Core to Core Program
    • Related Report
      2021 Annual Research Report
  • [Presentation] Thrombopoietin as an expansion factor for hematopoietic stem cells.2021

    • Author(s)
      Toshio Suda
    • Organizer
      International Conference of Korean Society of Hematology (ICKSH) 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hematopoietic stem cells and their niche.2020

    • Author(s)
      Toshio Suda
    • Organizer
      AMED -Gene & Cell Therapy Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] Quiescence and Cell Metabolism in Hematopoietic Stem Cells2020

    • Author(s)
      Toshio Suda
    • Organizer
      American Society of Hematology, 2020 Donnall Thomas Lecture (Virtual)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quiescence and cell metabolism in stem cells2019

    • Author(s)
      Toshio Suda
    • Organizer
      Japan-Singapore International Skin Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitocondria Metabolism in Quiescence and Cycling Hematopoietic Stem Cells2019

    • Author(s)
      Toshio Suda
    • Organizer
      ISEH 48th Annual Scientific Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MD Mitocondria metabolism in HSCs Stem Cells2019

    • Author(s)
      Toshio Suda
    • Organizer
      Stem Cells, Aging and Stress Response Mechanisms
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mitocondria metabolism in HSCS2019

    • Author(s)
      Toshio Suda
    • Organizer
      16th Nikko International Symposium
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mitocondria metabolism in HSCS2019

    • Author(s)
      Toshio Suda
    • Organizer
      University of Columbia Seminar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic Change in Hematopoietic Stem Cells2019

    • Author(s)
      Toshio Suda
    • Organizer
      2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 造血幹細胞とその微小環境2018

    • Author(s)
      須田年生
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Metabolic Regulation of Stem Cell Function2018

    • Author(s)
      Toshio Suda
    • Organizer
      Seminar in Lund University
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic Regulation of Stem Cell Function2018

    • Author(s)
      Toshio Suda
    • Organizer
      23rd Congress of EHA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protection of DNA damage in hematopoietic stem cells2018

    • Author(s)
      Toshio Suda
    • Organizer
      Hematopoietic stem cells X
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Purine metabolism in the divisions of hematopoietic stem cells2018

    • Author(s)
      Toshio Suda
    • Organizer
      KVBM-IBS Conference on Vascular Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Scientific committee session Purine metabolism in the divisions of hematopoietic stem cells2018

    • Author(s)
      Toshio Suda
    • Organizer
      61st ASH Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-06-12   Modified: 2022-12-28  

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