三次元膵癌モデルを用いた細胞と間質の相互作用および腫瘍の可塑性の解析
| Project/Area Number |
18J20132
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
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| Research Field |
Experimental pathology
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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| Research Fellow |
Hoh Hong Huat 沖縄科学技術大学院大学, 科学技術研究科, 特別研究員(DC1)
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| Project Period (FY) |
2018-04-25 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2020: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2019: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2018: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | pancreatic cancer / cell plasticity / invasion / tumor microenvironment / Pancreatic cancer / 3D / Organoids |
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| Outline of Annual Research Achievements |
In this fiscal year, I managed to finish the planned research projects- study of pancreatic cancer plasticity after treatment with self-assembling peptides and regulation of breast cancer stem cells by microRNA. Both projects showed promising results and effects by biologically mimic peptides and exogenous microRNA on pancreatic and breast cancer cell plasticity, leading to diminished tumor volume and invasion in vivo. Both studies were summarized as my doctoral thesis which was successfully defended within this fiscal year. Following graduation, I continue to study protein structure prediction and investigation using Cryo-electron microscopy and tomography which are important for drug discovery to widen my research skills and understanding in the field.
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| Research Progress Status |
令和2年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和2年度が最終年度であるため、記入しない。
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Report
(3 results)
Research Products
(4 results)
