運動時における後方循環系の脳循環調節機能を探る

• Project/Area Number: 18J20884
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Sports science (B)
• Research Institution: Toyo University
• Principal Investigator: 鷲尾 拓郎 東洋大学, 理工学研究科, 特別研究員(DC1)
• Project Period (FY): 2018-04-25 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥2,800,000 (Direct Cost: ¥2,800,000); Fiscal Year 2020: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2019: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2018: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 脳循環 / 運動 / 椎骨動脈 / 後大脳動脈 / 動脈二酸化炭素分圧 / 脳自己調節機能 / 交感神経活動

Outline of Annual Research Achievements

運動時における脳血流応答は、脳神経活動、脳代謝、その調節機能である動脈血圧に対する脳血管反応性（脳自己調節機能）、動脈二酸化炭素分圧、自律神経活動、体循環などの脳循環調節因子の影響を受けることが報告されている。しかしながら、これら脳循環調節機能に関する先行研究の知見は、主に中大脳動脈などの脳前方循環系を調査したものであり、脳後方循環系の後大脳動脈や椎骨動脈の循環調節機能は未だ明確でない。さらに、運動時の脳血流応答は、脳前方および後方循環系の間で異なり、この血流応答の違いは、脳循環調節機能の差異が影響している可能性が考えられる。そこで本申請研究では、脳後方循環系における生理メカニズムおよびその生理学的意義を解明することを目的とした。
新型コロナウィルス感染拡大防止の観点から、当初の予定していた実験遂行が困難であった。そのため、前年度行った実験のデータ解析（超音波画像解析）を行った。その結果、運動時の脳後方循環である後大脳動脈と椎骨動脈の血流応答およびその調節機能（動脈二酸化炭素分圧に対する脳血管反応性）に部位差が観察された。この運動に対する脳血流応答およびその調節機能の違いは、各血管に支配される脳の生理的役割の違いに依存することが推察される。したがって運動に対する脳血流応答の生理学的意義を理解するために、脳前方循環に加え脳後方循環における血流応答やその調節機能の測定を、測定部を考慮しながら行うことが重要であることが示唆された。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Greater increase in internal carotid artery shear rate during aerobic interval compared to continuous exercise in healthy adult men (2021)
  • Author(s): Ogoh Shigehiko、Washio Takuro、Suzuki Kazuya、Iemitsu Motoyuki、Hashimoto Takeshi、Iwamoto Erika、Bailey Damian M.
  • Journal Title: Physiological Reports Volume: 9 Issue: 2
  • DOI: 10.14814/phy2.14705
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of acute interval handgrip exercise on cognitive performance. (2021)
  • Author(s): Takuro Washio, Kazuya Suzuki, Shotaro Saito, Hironori Watanabe, Soichi Ando, R Matthew Brothers, Shigehiko Ogoh
  • Journal Title: Physiology & Behavior Volume: 232 Pages: 113327-113327
  • DOI: 10.1016/j.physbeh.2021.113327
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of intermittent isometric handgrip exercise protocol with short exercise duration on cognitive performance. (2021)
  • Author(s): Shotaro Saito, Takuro Washio, Hironori Watanabe, Soichi Ando, Shigehiko Ogoh.
  • Journal Title: The Journal of Physiological Sciences Volume: 71 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s12576-021-00796-z
  • Peer Reviewed / Open Access
• [Journal Article] Gravitational transitions increase posterior cerebral perfusion and systemic oxidative-nitrosative stress: implications for neurovascular unit integrity. (2020)
  • Author(s): Damian M Bailey, Damien Laneelle, Jean-Eudes Trihan, Nicola Marchi, Benjamin S Stacey, Kazuki Tamiya, Takuro Washio, Eduoard Tuaillon, Christophe Hirtz, Sylvain Lehmann, Shigehiko Ogoh, Herve Normand
  • Journal Title: Neuroscience Volume: 441 Pages: 142-160
  • DOI: 10.1016/j.neuroscience.2020.05.048
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gravitational effects on intracranial pressure and blood flow regulation in young men: a potential shunting role for the external carotid artery. (2020)
  • Author(s): Shigehiko Ogoh, Takuro Washio, Julian FR Paton, James P Fisher, Lonnie G Petersen
  • Journal Title: Journal of Applied Physiology Volume: 129 Issue: 4 Pages: 901-908
  • DOI: 10.1152/japplphysiol.00369.2020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Habitual cigarette smoking attenuates shear‐mediated dilation in the brachial artery but not in the carotid artery in young adults (2020)
  • Author(s): Suzuki Kazuya, Washio Takuro, Tsukamoto Shingo, Kato Kazunori, Iwamoto Erika, Ogoh Shigehiko
  • Journal Title: Physiological Reports Volume: 8 Issue: 3
  • DOI: 10.14814/phy2.14369
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic cerebral autoregulation in anterior and posterior cerebral circulation during cold pressor test (2020)
  • Author(s): Washio Takuro, Watanabe Hironori, Ogoh Shigehiko
  • Journal Title: The Journal of Physiological Sciences Volume: 70 Issue: 1
  • DOI: 10.1186/s12576-020-00732-7
  • Peer Reviewed / Open Access
• [Journal Article] Does respiratory drive modify the cerebral vascular response to changes in end‐tidal carbon dioxide? (2019)
  • Author(s): Ogoh Shigehiko, Suzuki Kazuya, Washio Takuro, Tamiya Kazuki, Saito Shotaro, Bailey Tom G, Shibata Shigeki, Ito Go, Miyamoto Tadayoshi
  • Journal Title: Experimental Physiology Volume: 104 Issue: 9 Pages: 1363-1370
  • DOI: 10.1113/ep087744
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acute reduction in posterior cerebral blood flow following isometric handgrip exercise is augmented by lower body negative pressure. (2018)
  • Author(s): Washio T, Vranish JR, Kaur J, Young BE, Katayama K, Fadel PJ, Ogoh S.
  • Journal Title: Physiol Rep. Volume: Oct;6(20) Issue: 20 Pages: e13886-e13886
  • DOI: 10.14814/phy2.13886
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of leg immersion in mild warm carbonated water on skin and muscle blood flow. (2018)
  • Author(s): Ogoh S, Washio T, Suzuki K, Ikeda K, Hori T, Olesen ND, Muraoka Y.
  • Journal Title: Physiol Rep. Volume: Sep;6(18) Issue: 18 Pages: e13859-e13859
  • DOI: 10.14814/phy2.13859
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulation of Regional Cerebral Blood Flow During Graded Reflex-Mediated Sympathetic Activation via Lower Body Negative Pressure. (2018)
  • Author(s): Kaur J, Vranish JR, Barbosa TC, Washio T, Young BE, Stephens BY, Brothers RM, Ogoh S, Fadel PJ.
  • Journal Title: J Appl Physiol. Volume: Sep 6; 125(6) Issue: 6 Pages: 1779-1786
  • DOI: 10.1152/japplphysiol.00623.2018
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Handgrip exercise modulates the cerebrovascular response to hypercapnia in the anterior and posterior circulation (2020)
  • Author(s): Takuro Washio, Hironori Watanabe, Kazuya Suzuki, Kazuki Tamiya, Shotaro Saito, Shigehiko Ogoh
  • Organizer: American college of sports medicine’s 67th annual meeting
  • Int'l Joint Research
• [Presentation] Effect of Breath holding on cerebral blood flow response to isometric exercise (2020)
  • Author(s): Hironori Watanabe, Takuro Washio, Koki Kimura, Shigehiko Ogoh
  • Organizer: American college of sports medicine’s 67th annual meeting
  • Int'l Joint Research
• [Presentation] Effect of intermittent isometric handgrip exercise on cognitive function (2020)
  • Author(s): Shotaro Saito, Kazuki Tamiya, Takuro Washio, Hironori Watanabe, Soichi Ando, Shigehiko Ogoh
  • Organizer: American collaege of sports medicine’s 67th annual meeting
  • Int'l Joint Research
• [Presentation] Interpretive complications underlying cerebrovascular response to hypercapnia; significant of the central respiratory chemoreflex transient (2020)
  • Author(s): Kazuki Tamiya, Takuro Washio, Tadayoshi Miyamoto, Damian Bailey, Shigehiko Ogoh
  • Organizer: American collaege of sports medicine’s 67th annual meeting
  • Int'l Joint Research
• [Presentation] Effect of different exercise modes on cerebrovascular shear in humans (2020)
  • Author(s): Shigehiko Ogoh, Takuro Washio, Kazuya Suzuki, Motoyuki Iemitsu, Takeshi Hashimoto, Erika Iwamoto, Damian Bailey
  • Organizer: American collaege of sports medicine’s 67th annual meeting
  • Int'l Joint Research
• [Presentation] The effects of acute isometric handgrip exercise on cognitive function (2020)
  • Author(s): Takuro Washio, Kazuya Suzuki, Shotaro Saito, Kazuki Tamiya, Hironori Watanabe, Soichi Ando, Shigehiko Ogoh
  • Organizer: 日本生理学会
• [Presentation] Effect Of Isometric Handgrip Exercise On Hypercapnia-induced Shear-mediated Dilation In The Internal Carotid Artery (2019)
  • Author(s): Takuro Washio, Kazuya Suzuki, Takashi Yamagata, Soichi Ando, Shigehiko Ogoh
  • Organizer: American College of Sports Medicine Annual Meeting
  • Int'l Joint Research
• [Presentation] 低酸素暴露が脳血流依存性血管拡張反応に及ぼす影響 (2019)
  • Author(s): 鷲尾拓郎, 塚本敏人, Damian M Bailey, 小河繁彦
  • Organizer: 日本体力医学会
• [Presentation] 下半身陰圧負荷時における脳自己調節機能の解明 (2019)
  • Author(s): 渡邊裕宣，鷲尾拓郎，平澤愛，柴田茂貴，小河繁彦
  • Organizer: 日本体力医学会
• [Presentation] 喫煙習慣が末梢及び脳血管の血流依存性血管拡張反応に及ぼす影響 (2019)
  • Author(s): 鈴木一也, 鷲尾拓郎, 塚本真伍, 加藤和則, 岩本えりか, 小河繁彦
  • Organizer: 日本体力医学会
• [Presentation] 呼吸様式の違いが血中二酸化炭素分圧変化に対する脳血管反応を変化させるか？ (2019)
  • Author(s): 小河繁彦, 鈴木一也, 鷲尾拓郎, 田宮一樹, 斎藤祥太郎, Tom G. Bailey, 柴田茂貴, 伊藤剛, 宮本忠吉
  • Organizer: 日本体力医学会
• [Presentation] Effect of cigarette smoking on hypercapnia induced shear-mediated dilation in the internal carotid artery (2019)
  • Author(s): Kazuya Suzuki, Takuro Washio, Shingo Tsukamoto, Kazunori Kato, Erika Iwamoto, Shigehiko Ogoh
  • Organizer: Experimental Biology
  • Int'l Joint Research
• [Presentation] Effect of Sympathetic Activation on Dynamic Cerebral Autoregulation in Posterior Cerebral Circulation (2018)
  • Author(s): Takuro Washio,Masato Hatanaka, Kazuya Suzuki, Shigehiko Ogoh
  • Organizer: American College of Sports Medicine Annual Meeting
  • Int'l Joint Research
• [Presentation] 寒冷昇圧試験が脳血管緊張に及ぼす影響 (2018)
  • Author(s): 鷲尾拓郎 鈴木一也 小河繁彦
  • Organizer: 体力医学会