|Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|Outline of Final Research Achievements
The amino acid sequences of major histocompatibility gene complex (MHC) proteins, which present antigens derived from pathogens such as viruses, differs in sequence among species, limiting evaluation of biopharmaceuticals such as vaccines using mice. However, humanization of many MHC genes is technically difficult. In this study, we attempted to establish MHC humanized mice.