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Mechanistic analysis of plant memory erasure using a mutant with unforgettable stress experience

Research Project

Project/Area Number 18K06069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 43010:Molecular biology-related
Research InstitutionNihon University

Principal Investigator

TSUCHIYA Tokuji  日本大学, 生物資源科学部, 講師 (80758459)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords植物の記憶 / エピジェネティクス / 転写制御 / シロイヌナズナ / 記憶 / 環境記憶 / クロマチン
Outline of Final Research Achievements

Once a plant experiences environmental stress, it can exhibit greater tolerance during a second stress, compared to a plant that has not. In this way, plants have the ability to memorize environmental stresses such as pathogen infections and prepare for secondary stresses. On the other hand, long-term retention of unnecessary memory increases the cost of adaptation. Therefore, it is considered necessary to properly control the balance between memory formation and erasure in order to adapt to the environment.
In this study, I analyzed the function of genes required to appropriately erase the memory formed by plants during pathogen infection. As a result, it was shown that the gene named UTF1 plays an important role in memory erasure.

Academic Significance and Societal Importance of the Research Achievements

植物が環境ストレスを記憶する事例は、植物の形態や成長速度などの表現型レベルでは古くから知られていた。しかし、遺伝子機能などの分子レベルでの研究は世界的に見ても未だ創生期にある。数少ない研究例としては、冬(低温)や高温ストレスを記憶する際の遺伝子レベルでの機能解析が挙げられる。しかしながら、本研究で着目する免疫記憶消去メカニズムの報告例はない。
本研究で解析したUTF1が機能しなければ、病原体非感染時にも常にコストを払う必要が生じるため、植物個体は矮化し、作物においては収量が低下すると考えられる。よって、UTF1の機能解析は安定した農作物の生産にも貢献すると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression2020

    • Author(s)
      Lai Yan、Lu Xueqing Maggie、Daron Josquin、Pan Songqin、Wang Jianqiang、Wang Wei、Tsuchiya Tokuji、Holub Eric、McDowell John M.、Slotkin R. Keith、Le Roch Karine G.、Eulgem Thomas
    • Journal Title

      PLOS Genetics

      Volume: 16 Issue: 9 Pages: e1008993-e1008993

    • DOI

      10.1371/journal.pgen.1008993

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel Arabidopsis pathosystem reveals cooperation of multiple hormonal response-pathways in host resistance against the global crop destroyer Macrophomina phaseolina2019

    • Author(s)
      Schroeder MM, Lai Y, Shirai M, Alsalek N1, Tsuchiya T, Roberts P, Eulgem T
    • Journal Title

      Scientific reports

      Volume: 9(1) Issue: 1 Pages: 20083-20083

    • DOI

      10.1038/s41598-019-56401-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Aphid effector Me10 interacts with tomato TFT7, a 14-3-3 isoform involved in aphid resistance2019

    • Author(s)
      Chaudhary Ritu、Peng Hsuan-Chieh、He Jiangman、MacWilliams Jacob、Teixeira Marcella、Tsuchiya Tokuji、Chesnais Quentin、Mudgett Mary Beth、Kaloshian Isgouhi
    • Journal Title

      New Phytologist

      Volume: 221 Issue: 3 Pages: 1518-1528

    • DOI

      10.1111/nph.15475

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts2019

    • Author(s)
      Lai Yan、Cuzick Alayne、Lu Xueqing M.、Wang Jianqiang、Katiyar Neerja、Tsuchiya Tokuji、Le Roch Karine、McDowell John M.、Holub Eric、Eulgem Thomas
    • Journal Title

      The Plant Journal

      Volume: 97 Issue: 4 Pages: 646-660

    • DOI

      10.1111/tpj.14148

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Pathogen challenge to Arabidopsis cotyledons sets sustained upregulation of a WRKY gene and defense priming at newly formed rosette leaves2020

    • Author(s)
      SUKAOUN KANOKNIPA, 土屋 徳司
    • Organizer
      日本植物生理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Pathogen challenge to Arabidopsis cotyledons sets sustained upregulation of a WRKY gene and defense priming at newly formed rosette leaves2020

    • Author(s)
      SUKAOUN KANOKNIPA, 土屋 徳司
    • Organizer
      日本育種学会
    • Related Report
      2019 Research-status Report
  • [Presentation] シロイヌナズナにおけるFLOWERING LOCUS Cをターゲットとしたエピゲノム編集による花成時期の制御2020

    • Author(s)
      五十嵐 寛太, 土屋 徳司
    • Organizer
      日本育種学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Relationship between defense priming and sustained upregulation of WRKY transcript levels induced by Hyaloperonospora arabidopsidis infection in Arabidopsis2019

    • Author(s)
      SUKAOUN KANOKNIPA, 土屋 徳司
    • Organizer
      日本植物生理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] シロイヌナズナにおいてHyaloperonospora arabidopsidis感染により誘導されるWRKY 転写産物量の長期保持とプライミング状態の関係性2018

    • Author(s)
      SUKAOUN KANOKNIPA, 土屋 徳司
    • Organizer
      日本育種学会
    • Related Report
      2018 Research-status Report
  • [Presentation] シロイヌナズナにおけるエピジェネティック制御因子EDM2とその相互作用因子であるユビキチンE3リガーゼによる耐病性制御メカニズムの解析2018

    • Author(s)
      渡邉亮介, 土屋徳司
    • Organizer
      日本育種学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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