Integrated analysis of the multi-layered tumor suppressor system woven by p53 and AMPK
| Project/Area Number |
18K06206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 44010:Cell biology-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | p53 / AMPK / 細胞内構造 / オルガネラ |
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| Outline of Final Research Achievements |
Recently, metabolic regulation by the transcription factor p53 has been shown to play an important role in suppressing cancer. This p53-mediated metabolic regulation requires appropriate control of the spatiotemporal activity of AMPK, which is one of the target molecules for cancer therapy. However, the mechanism of cancer suppression by the p53-AMPK axis has not been fully elucidated.
Although this study did not elucidate the mechanism of cancer suppression by the p53-AMPK axis, we succeeded in developing fundamental technologies necessary for future research development, such as the relationship between p53 and nutrient metabolism and improved visualization of the spatiotemporal activity dynamics of AMPK.
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| Academic Significance and Societal Importance of the Research Achievements |
転写因子p53やリン酸化酵素AMPKの機能を理解することは、より効果的ながんの治療法や予防法を開発していく上で、極めて有用である。
本研究ではp53-AMPK axisによるがん抑制メカニズムを解明するには至らなかったが、p53と栄養代謝の関連性、AMPKの時空間的な活性ダイナミクスの可視化の改良など、今後の研究展開に必要な基盤技術の開発に成功した。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice2020
Author(s)
Matsuzaka T, Kuba M, Koyasu S, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.
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Journal Title
Hepatology
Volume: 71
Pages: 1609-1625
DOI
NAID
Description
in press
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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