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A novel function of cyclin dependent kinase A in land plants

Research Project

Project/Area Number 18K06273
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 44030:Plant molecular biology and physiology-related
Research InstitutionHokkaido University

Principal Investigator

Fujita Tomomichi  北海道大学, 理学研究院, 教授 (50322631)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsサイクリン依存性キナーゼ / 環境応答 / 新機能 / 植物 / 動物 / 非生物ストレス / ヒメツリガネゴケ / ストレス
Outline of Final Research Achievements

Our results show that PpCDKA is a factor with important functions in various environmental stress responses, in addition to the cell cycle. In particular, we studied in detail the mechanism of molecular regulation of light responses by CDKA and found that CDKA regulates light responses independently of cell cycle regulation, and that this function is conserved not only in Physcomitrella patens but also in the angiosperm Arabidopsis thaliana. We also proposed that CDK1, a CDKA orthologue in humans and animals, may regulate environmental responses in addition to the cell cycle.

Academic Significance and Societal Importance of the Research Achievements

CDKAが細胞周期とは独立に光応答を制御するという機能はこれまで知られておらず、またこの機能が陸上植物に保存されたものであるという発見の学術的意義は極めて高い。また本研究によりヒトを含む動物においてもCDKAオルソログ、CDK1がストレス応答に関与している可能性が考えられ、この機能と疾病の関与を今後新たに検討することが必要になるかもしれない。このように本研究は基礎植物学のみならず農学や医学など幅広い分野に影響を与える社会的意義の高いものである。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report

Research Products

(10 results)

All 2021 2020 2019 2018 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] How plants grow under gravity conditions besides 1 g: Perspectives from hypergravity and space experiments that employ bryophytes as a model organism2021

    • Author(s)
      Kume, A., Kamachi, H., Onoda, Y., Hanba, T.Y., Hiwatashi, Y., Karahara, I., and Fujita T.
    • Journal Title

      Plant and Cell Physiology

      Volume: - Pages: 348-355

    • DOI

      10.1093/pcp/pcaa165

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1gとは異なる重力環境で植物はどのように育つのだろうか -コケ植物を用いた宇宙実験(スペース・モス)から期待できること-2020

    • Author(s)
      藤田知道, 久米篤, 蒲池浩之, 小野田雄介, 半場祐子, 日渡祐二, 唐原一郎
    • Journal Title

      BSJ-Review

      Volume: 11 Issue: A Pages: 60-74

    • DOI

      10.24480/bsj-review.11a6.00178

    • ISSN
      2432-9819
    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The PSI-PSII megacomplex in green plants.2019

    • Author(s)
      Yokono M, Takabayashi A, Kishimoto J, Fujita T, Iwai M, Murakami A, Akimoto S, Tanaka A.
    • Journal Title

      Plant and Cell Physiology

      Volume: 印刷中 Pages: 1098-1108

    • DOI

      10.1093/pcp/pcz026

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Formation of a PSI-PSII megacomplex containing LHCSR and PsbS in the moss Physcomitrella patens2019

    • Author(s)
      Furukawa, R., Aso M, Fujita, T., Akimoto, S., Tanaka, R., Tanaka, A., Yokono, M., and Takabayashi, A.
    • Journal Title

      J Plant Res

      Volume: 132 Pages: 867-880

    • DOI

      10.1007/s10265-019-01138-2

    • NAID

      120006941693

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒメツリガネゴケを用いた葉緑体集合運動のシグナル伝達系においてCDKAが制御する過程の探索2020

    • Author(s)
      森本智郎、井上夏実、門田明雄、藤田知道
    • Organizer
      日本植物学会第84会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 陸上植物におけるCDKAによる葉緑体運動制御2019

    • Author(s)
      井上夏実,Liang Bao,菅原駿人, 石川雅樹,後藤栄治,関根政実, Ooikock Teh,長谷部光泰,和田正三,藤田 知道
    • Organizer
      日本植物学会第83会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Requirement of kinase activity of CDKA on the novel functions in the moss, Physcomitrella patens2019

    • Author(s)
      Eggie Febrianto Ginanjar, Masaki Ishikawa, Masami Sekine, Natsumi Inoue, Mitsuyasu Hasebe, Ooi-Kock Teh, and Tomomichi Fujita
    • Organizer
      第60回日本植物生理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] PpCDKA controls light signaling in Physcomitrella patens2018

    • Author(s)
      Natsumi Inoue, Liang Bao, Masaki Ishikawa, Takeshi Higa, Yuji Hiwatashi, Masami Sekine, Ooi-Kock Teh, Mitsuyasu Hasebe, Masamitsu Wada, Tomomichi Fujita
    • Organizer
      iMOSS 2018
    • Related Report
      2018 Research-status Report
  • [Remarks]

    • URL

      https://www.sci.hokudai.ac.jp/PlantSUGOIne/publication/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 研究業績

    • URL

      https://www.sci.hokudai.ac.jp/PlantSUGOIne/publication/

    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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