Studies on the adaptive behavioral strategies associated with animal learning and memory

• Project/Area Number: 18K06341
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
• Research Institution: Tottori University (2020); Gakushuin University (2018-2019)
• Principal Investigator: INOUE Takeshi 鳥取大学, 医学部, 准教授 (40391867)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 環境適応 / 環境応答 / 環境変化 / 行動生理 / 腸-脳軸 / 定量行動 / プラナリア / 行動制御 / 連合学習 / 外部環境 / 適応行動 / 末梢神経 / 脳高次機能 / 定量行動学 / 学習 / 環境応答行動 / 行動

Outline of Final Research Achievements

Even subtle changes in environmental factors can exert behavioral effects on creatures, altering interspecific interactions and eventually affecting the ecosystem. However, how animals associated with complex behaviors regulated by neural processes adapt to the changes in the environment is largely unknown. The freshwater planarian Dugesia japonica displays distinct behavioral traits mediated by sensitive perception of environmental cues. Planarians are thus beneficial organisms for examining interactions between environmental changes and specific behaviors of animals. Here we found that the signaling from the peripheral pharynx nervous system to the brain and the sensitivity of the chemosensory neurons directly modulated by the environmental chemical factor critically impact individual feeding behavior related with the growth and survival in planarian. These results suggest that the peripheral nervous system orchestrates planarian behavior at the individual animal level.

Academic Significance and Societal Importance of the Research Achievements

動物行動における環境適応性の複雑な作動原理については大部分が不明である。本研究では、環境変化に伴ってプラナリアが出力行動を適応的に選択する現象に着目し、その機構を非常に単純な原理として理解しようとする点が独創的であり学術的に意義深い。また、水生生物であるプラナリアの行動様式の機構に関する研究は、SDGsの「9.産業と技術革新の基盤をつくろう」および「14.海の豊かさを守ろう」に貢献する。

Research Products

• [Journal Article] The pharyngeal nervous system orchestrates feeding behavior in planarians (2020)
  • Author(s): Miyamoto Mai、Hattori Miki、Hosoda Kazutaka、Sawamoto Mika、Motoishi Minako、Hayashi Tetsutaro、Inoue Takeshi、Umesono Yoshihiko
  • Journal Title: Sci Adv Volume: 6
  • DOI: 10.1126/sciadv.aaz0882
  • Peer Reviewed / Open Access
• [Journal Article] ECM-body: A cell-free 3D biomimetic scaffold derived from intact planarian body (2020)
  • Author(s): Sonpho, E., Wootthichairangsan, C., Ishida, M., Inoue, T., Agata, K., Maleehuan, A., Charngkaew, K., Chomanee, N., Moonsom, S., Wongtrakoongate, P., Chairoungdua, A., Ounjai, P.
  • Journal Title: Zoological Science Volume: 37 Issue: 4 Pages: 307-307
  • DOI: 10.2108/zs190135
  • NAID: 210000177975
  • ISSN: 0289-0003
  • Peer Reviewed / Open Access
• [Journal Article] JmjC domain-encoding genes are conserved in highly regenerative metazoans and are associated with planarian whole-body regeneration (2019)
  • Author(s): Cao P, Kumagai N, Inoue T, Agata K and Makino T.
  • Journal Title: Genome Biol Evol Volume: 11(2) Pages: 552-564
  • DOI: 10.1093/gbe/evz021
  • Peer Reviewed / Open Access
• [Journal Article] Calcium ions in the aquatic environment drive planarians to food (2019)
  • Author(s): Mori, M., Narahashi, M., Hayashi, T., Ishida, M., Kumagai, N., Sato, Y., Bagherzadeh, R., Agata, K., Inoue, T.
  • Journal Title: Zoological Lett Volume: 5 Pages: 31-31
  • DOI: 10.1186/s40851-019-0147-x
  • Peer Reviewed / Open Access
• [Journal Article] Coordination between binocular field and spontaneous self-motion specifies the efficiency of planarians' photo-response orientation behavior (2018)
  • Author(s): Akiyama, Y. Agata, K. Inoue, T.
  • Journal Title: Commun Biol Volume: 1 Pages: 148-148
  • DOI: 10.1038/s42003-018-0151-2
  • Peer Reviewed / Open Access
• [Presentation] 無性と有性生殖で増えるプラナリアDugesia ryukyuensisのゲノム決定 (2019)
  • Author(s): 嶋崎 綾、井上 武、重信秀治、関井清乃、小林一也、阿形清和
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] プラナリアの周期性自発的運動の解析 (2019)
  • Author(s): 楢橋真理環、阿形 清和、井上 武
  • Organizer: 日本動物学会第90回大会
• [Presentation] Coupling of sensory architecture and spontaneous self-motion enables adaptive behaviors in planarians (2019)
  • Author(s): T. Inoue, Y. Akiyama, K. Agata
  • Organizer: 日本動物学会第90回大会
  • Invited
• [Presentation] プラナリアの脳機能再生におけるる環境刺激入力の役割 (2019)
  • Author(s): 井上 武
  • Organizer: 第2回再生学異分野融合研究会
  • Invited
• [Presentation] Planarian Promoter Architecture (2019)
  • Author(s): R. Bagherzadeh, R. Deviatiiarov, E.a Minkina, S. Ahmad Mousavi, A. Sharifi-Zarchi, T. Inoue, O. Gusev, H. Bahrvand, K. Agata
  • Organizer: 52nd Annual Meeting of the Japanease Scociety of Developmental Biologists
• [Presentation] "Ion concentration of the breeding water affects feeding behavior in planarian Dugesia japonica" (2018)
  • Author(s): M. Mori, M. Ishida, N. Kumagai, Y. Sato, K. Agata, T. Inoue
  • Organizer: 2018 International Planarian Meeting
  • Int'l Joint Research
• [Presentation] Co-adaptation between sensory structures and spontaneous self-motion for ensuring the effectiveness of multiple behaviors (2018)
  • Author(s): T. Inoue, Y. Akiyama, K. Agata
  • Organizer: 2018 International Planarian Meeting
  • Int'l Joint Research / Invited
• [Presentation] Close relationship between the eye architecture and the spontaneous self-motion establishes robust photo-response orientation behavior in planarians (2018)
  • Author(s): T. Inoue
  • Organizer: The International Research Symposium on Germness and Pluripotency of the Planarians in comparison with the Fly and Mouse Systems
  • Int'l Joint Research / Invited
• [Book] “扁形動物と脳の再生”, 遺伝子から解き明かす脳の不思議な世界. 村上安則, 野村真, 滋野修一 編 (2018)
  • Author(s): 井上 武
  • Total Pages: 520
  • Publisher: 一色出版
  • ISBN: 4909383050