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Functional MRI Brain imaging in Torpid Mice

Research Project

Project/Area Number 18K06347
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Genshiro Sunagawa  国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (70710250)

Co-Investigator(Kenkyū-buntansha) 佐々木 崇了  岡山大学, 医歯薬学総合研究科, 助教 (10461253)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords休眠 / 冬眠 / 能動的低代謝 / 機能的MRI / 非侵襲代謝評価 / マウス
Outline of Final Research Achievements

This project aims to observe the local dynamics of the brain during torpor. Torpor is induced by 24-hour fasting of mice. The brain of any torpid animals, including hibernators, have not been reported to be evaluated under functional MRI. Active hypometabolism of torpor is promising for harmful high-metabolism conditions in medicine. We experienced difficulty inducing torpor in the MRI; however, we have nearly overcome the issue by developing QIH, an inducible hibernation-like condition in mice.

Academic Significance and Societal Importance of the Research Achievements

あ休眠現象は組織の酸素需要を低下させることで動物の個体としての代謝が低下した状態である。臨床における重症状態は原則的に末梢組織の酸素需要が満たされないことに起因するため、休眠を患者に誘導することで今では助からない患者が多く救命できる可能性がある。休眠動物の機能的MRIを観察することで休眠の原理解明に近づくだけではなく、中枢神経系における休眠中の代謝ダイナミクスを観察できる。本計画年限ではMRI撮像にまでは至らなかったが、動物をMRI内で休眠させられる目処はついた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report

Research Products

(13 results)

All 2020 2019 2018

All Journal Article (2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 休眠とその医学応用可能性2020

    • Author(s)
      砂川玄志郎
    • Journal Title

      実験医学

      Volume: 6 Pages: 978-981

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 睡眠と冬眠と代謝2019

    • Author(s)
      砂川 玄志郎
    • Journal Title

      睡眠医療

      Volume: 13 Pages: 137-141

    • Related Report
      2019 Research-status Report
  • [Presentation] A hibernation-like condition in mice: the physiological aspects of Q neurons-induced hypometabolism.2020

    • Author(s)
      砂川 玄志郎
    • Organizer
      第43回 分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 冷たいことには理由がある ~冬眠から考える人類の未来~2020

    • Author(s)
      砂川 玄志郎
    • Organizer
      日本神経科学大会 市民公開パネルディスカッション「2050年の脳科学と社会」
    • Related Report
      2020 Annual Research Report
  • [Presentation] A discrete neuronal circuit induces a hibernation-like state in rodents2020

    • Author(s)
      砂川 玄志郎
    • Organizer
      Hibernation Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 冬眠のひみつ2019

    • Author(s)
      Genshiro A. Sunagawa
    • Organizer
      文部科学省 新学術領域研究 「温度生物学」 市民公開講座
    • Related Report
      2019 Research-status Report
  • [Presentation] マウスを用いた人工冬眠の研究2019

    • Author(s)
      Genshiro A. Sunagawa
    • Organizer
      第63回 宇宙科学技術連合講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] Daily torpor in mice as a model of active hypometabolism in mammals2019

    • Author(s)
      Genshiro A. Sunagawa
    • Organizer
      NEURO2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス休眠をモデルとした能動的低代謝の研究: 骨格筋における休眠特異的遺伝子発現の解析2019

    • Author(s)
      Genshiro A. Sunagawa
    • Organizer
      第3回冬眠休眠研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] マウスの日内休眠における骨格筋の遺伝子発現の変化2019

    • Author(s)
      Genshiro A. Sunagawa
    • Organizer
      第22回日本脳低温療法・体温管理学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 冬眠の臨床応用に向けて:能動的低代謝を体温管理療法に応用できるか?2019

    • Author(s)
      Genshiro A. Sunagawa
    • Organizer
      第22回日本脳低温療法・体温管理学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Physiological Phenotyping by Non-invasive Respiratory Recordings2018

    • Author(s)
      Genshiro A Sunagawa
    • Organizer
      The 41st Annual Meeting of the Molecular Biology Society of Japan
    • Related Report
      2018 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 冬眠様状態を誘発する方法およびそのための装置2019

    • Inventor(s)
      櫻井武、高橋徹、砂川玄志郎
    • Industrial Property Rights Holder
      櫻井武、高橋徹、砂川玄志郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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