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Addressing a model of mycobacterium evolution via sexual reproduction: approaches by molecular genetics and population genomics

Research Project

Project/Area Number 18K06357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 45020:Evolutionary biology-related
Research InstitutionTohoku University

Principal Investigator

Yano Hirokazu  東北大学, 生命科学研究科, 講師 (20646773)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords抗酸菌 / プラスミド / 集団ゲノミクス / ゲノム / 系統進化 / 非結核性抗酸菌 / 遺伝的集団構造 / 地域適応 / 接合
Outline of Final Research Achievements

We revealed population structure of M.avium subsp.hominisuiss (MAH) using publicly available genomic data, then detected exchanges of chromosomal fragments between two lineages one carrying many recombination footprints and the other carrying little. We found a recombination-cold region on the MAH chromosome, wherein the polymorphism can be used as lineage markers for genotyping. We released complete genome sequences of 5 MAH strains after polishing sequences. We obtained evidence that MAH carry plasmids.

Academic Significance and Societal Importance of the Research Achievements

抗酸菌の一種Mycobacterium avium (MAC菌) は難治性の肺MAC症の原因菌である。日本で社会問題となっているM.aviumが組換えを行う菌種であることはゲノム情報から推察されているものの、実験による再現が報告されていない。本研究は日本の M.aviumがどのような条件で何の遺伝子を交換しているのか解明することを見据え、それを実現するための実験系構築とデータセット構築を目指したものである。得られる情報は今後のM.aviumを用いた分子遺伝学実験や細菌GWAS研究に有用な知見を提供すると期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019 2018 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (8 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Genetic relatedness of Mycobacterium avium subsp. hominissuis isolates from bathrooms of healthy volunteers, rivers, and soils in Japan with human clinical isolates from different geographical areas2019

    • Author(s)
      Arikawa Kentaro、Ichijo Tomoaki、Nakajima Satomi、Nishiuchi Yukiko、Yano Hirokazu、Tamaru Aki、Yoshida Shiomi、Maruyama Fumito、Ota Atsushi、Nasu Masao、Starkova Daria A.、Mokrousov Igor、Narvskaya Olga V.、Iwamoto Tomotada
    • Journal Title

      Infection, Genetics and Evolution

      Volume: 74 Pages: 103923-103923

    • DOI

      10.1016/j.meegid.2019.103923

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The recombination-cold region as an epidemiological marker of recombinogenic opportunistic pathogen Mycobacterium avium2019

    • Author(s)
      Yano Hirokazu、Suzuki Haruo、Maruyama Fumito、Iwamoto Tomotada
    • Journal Title

      BMC Genomics

      Volume: 20 Issue: 1 Pages: 752-752

    • DOI

      10.1186/s12864-019-6078-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconsidering plasmid maintenance factors for computational plasmid design2019

    • Author(s)
      Yano H, Shintani M, Tomita M, Suzuki H, and Oshima T
    • Journal Title

      Comput. Struct. Biotechnol. J.

      Volume: 17 Pages: 70-81

    • DOI

      10.1016/j.csbj.2018.12.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] GWASアプローチによる肺MAC症の病態に関連する細菌側因子の探索2021

    • Author(s)
      矢野 大和, 西内 由紀子, 有川 健太郎, 大田 篤, 三木 真理, 丸山 史人, 木田 博, 北田 清悟, 岩本 朋忠
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Local diversification of MAC lung disease agent Mycobacterium avium2020

    • Author(s)
      Hirokazu Yano, Fumito Maruyama, Yukiko Nishiuchi, Tomotada Iwamoto
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Population evolution of recombinogenic opportunistic pathogen Mycobacterium avium2019

    • Author(s)
      Hirokazu Yano, Fumito Maruyama, Tomotada Iwamoto
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] tRNAアレーを運ぶ線状プラスミドの発見2019

    • Author(s)
      矢野大和、永田裕二、丸山史人、西内由紀子、岩本朋忠
    • Organizer
      第13回細菌学若手コロッセウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺MAC症原因菌Mycobacterium aviumのゲノム疫学2019

    • Author(s)
      矢野大和
    • Organizer
      第73回日本細菌学会東北支部総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺MAC症原因菌Mycobacterium aviumのゲノム疫学2019

    • Author(s)
      矢野大和、丸山史人、西内由紀子、岩本朋忠
    • Organizer
      第4回抗酸菌研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺MAC症原因菌Mycobacterium aviumの地域多様化2019

    • Author(s)
      矢野大和、丸山史人、岩本朋忠
    • Organizer
      第1回遺伝学会春季分科会 国立遺伝学研究所 2019年3月8日
    • Related Report
      2018 Research-status Report
  • [Presentation] モザイクゲノム生物非結核性抗酸菌の集団進化2018

    • Author(s)
      矢野大和、丸山史人、岩本朋忠
    • Organizer
      生命科学フロンティアミーティング 国立遺伝学研究所 2018年10月5日-7日
    • Related Report
      2018 Research-status Report
  • [Remarks] Hirokazu Yano

    • URL

      https://sites.google.com/view/hirokazuyano/home

    • Related Report
      2019 Research-status Report 2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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