Development of synthetic receptors for heme based on a supramolecular chemistry approach and applications toward chemical biology
| Project/Area Number |
18K06551
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
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| Research Institution | Nagoya City University |
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Principal Investigator |
Yosuke Hisamatsu 名古屋市立大学, 医薬学総合研究院(薬学), 講師 (80587270)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヘム / 蛍光 / 人工レセプター / ホスト・ゲスト化学 / 超分子化学 / ホストゲスト化学 / 超分子 / 自己集合 / プロトポルフィリンIX / 光増感剤 / 光線力学療法 / 蛍光プローブ / ピンセット分子 |
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| Outline of Final Research Achievements |
Heme plays important roles in a variety of biological systems and the development of tools for the detection of heme in living cells is important for understanding of physiological roles of heme. In this research project, new tweezer-type synthetic receptors that form stable complexes with heme were developed. Moreover, the fluorescent synthetic receptor exhibits a heme-concentration dependent fluorescence response in aqueous solution at neutral pH.
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| Academic Significance and Societal Importance of the Research Achievements |
生体分子を水中で精密に認識する人工レセプターの開発と応用は、ホスト・ゲスト化学の分野において重要な研究課題の一つである。本研究期間において、生体内で重要な役割を持つヘムに対して高い結合親和性と蛍光応答性をもつ新規人工レセプターを開発した。今後、本研究で得られた知見を活用し改善を加えることで、ヘムの研究に貢献できる実用的なツールへと発展させたい。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme2018
Author(s)
Yosuke Sakata, Kosuke Yabunaka, Yuko Kobayashi, Hirohisa Omiya, Naoki Umezawa, Hye- Sook Kim, Yusuke Wataya, Yoshimi Tomita, Yosuke Hisamatsu, Nobuki Kato, Hirokazu Yagi, Tadashi Satoh, Koichi Kato, Haruto Ishikawa and Tsunehiko Higuchi
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Journal Title
ACS Medicinal Chemistry Letters
Volume: 9
Pages: 980-985
DOI
Related Report
Peer Reviewed / Open Access
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