Development of Sulfo-Sialic Acids into Next-Generation Antimicrobial Agents
| Project/Area Number |
18K06577
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
清田 洋正 岡山大学, 環境生命科学研究科, 教授 (30234397)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | Synthetic biology / Sulfo-sialic acid / Fluorine / Covalent inhibitor / Neuraminidase (NA) / Antivirals / Anomeric sulfo / Anomeric phosphono / NA inhibitor / Anomeric sulfonate / Bioproduction / Anti-virals / Sialic acid / Sulfonic acids / Neuraminidase / Covalent inhibitors / Microwave reaction / Decarboxylation / Fluoro sugars / Influenza neuraminidase / Drug development / Novel carbohydrates |
|---|
| Outline of Final Research Achievements |
Fluorinated sulfonates and phosphonates were designed as inhibitors of sialic acid binding viruses. Three milestones were reached to produce target sialic acid analogues: 1) C-2 fluorine introduction into pyranose analogues, 2) introduction of fluorine and hydroxy groups into C-1 and C-2 positions of open-chain analogues, and 3) substitution of the sialic acid anomeric carboxy with a sulfonamide group.
|
| Academic Significance and Societal Importance of the Research Achievements |
このプロジェクトで開発した化合物群は、将来の感染爆発（パンデミック）に備えた抗ウィルス薬リードとして役立つものです。そして、薬剤耐性を獲得した微生物・ウィルスにも幅広く効果を示す可能性を持っています。さらには、本化合物群の微生物生産システムも構築しました。本手法は、従来、高価値な医薬品製造のために行っていた工業化学的プロセスを代替する持続可能な手段となり得ます。
|
Report
(4 results)
Research Products
(8 results)
-
-
-
-
[Journal Article] Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids2019
Author(s)
Christopher J. Vavricka, Takanobu Yoshida, Yuki Kuriya, Shunsuke Takahashi, Teppei Ogawa, Fumie Ono, Kazuko Agari, Hiromasa Kiyota, Jianyong Li, Jun Ishii, Kenji Tsuge, Hiromichi Minami, Michihiro Araki, Tomohisa Hasunuma, Akihiko Kondo
-
Journal Title
Nature Communications
Volume: 10
Pages: 2015-2015
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
