Development of Organocatalysts Based on Chiarity Transfer and Remote Electronic Effect
| Project/Area Number |
18K06579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMADA Ken-ichi 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 (00335184)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 不斉触媒 / 不斉触媒開発 / 有機分子触媒 / キラリティー伝播 / 遠隔位電子効果 |
|---|
| Outline of Final Research Achievements |
In this project, development of new chiral organocatalyst was pursued on the basis of chirality transfer and remote electronic tuning. Finally, we developed a novel chiral thiourea and selenourea catalysts, which were then applied to a bromolactonization reaction to achieve high enantio- and 5-exo-selectivities.
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| Academic Significance and Societal Importance of the Research Achievements |
以上の研究成果によって、研究代表者が不斉配位子において既に示した不斉伝播による反応制御の概念が有機分子触媒へも適用可能であることが示された。今後、本設計概念に基づく新たな有用触媒の開発が期待される。また、新規不斉触媒の開発によって、これまで困難であった分子変換が可能となった。本反応によって得られる分子群は、医薬品をはじめとする有用物質を創生するための合成原料としての利用が期待される。
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Mechanistic Support for Intramolecular Migrative Cyclization of Propargyl Sulfones Provided by Catalytic Asymmetric Induction with a Chiral Counter Cation Strategy.2021
Author(s)
Yamasaki, K.; Yamauchi, A.; Inokuma, T.; Miyakawa, Y.; Wang, Y.; Oriez, R.; Yamaoka, Y.; Takasu, K.; Tanaka, N.; Kashiwada, Y.; Yamada, K.
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Journal Title
Asian J. Org. Chem.
Volume: -
Issue: 7
Pages: 1828-1834
DOI
Related Report
Peer Reviewed
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[Presentation] Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine.2019
Author(s)
Shingo Harada, Masato Kono, Tomoyuki Nozaki, Yoshinori Hashimoto, Shun-ichi Murata, Harald Groeger, Yusuke Kuroda, Ken-ichi Yamada, Kiyosei Takasu, Yasumasa Hamada, Tetsuhiro Nemoto
Organizer
The 13th CeBiTec Symposium: Multi-Step Syntheses in Biology & Chemistry
Related Report
Int'l Joint Research
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