Multi-omics analysis of brain exosomes on drug abuse
| Project/Area Number |
18K06674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Exosome / 危険ドラッグ / 統合オミクス / 覚醒剤 / 麻薬 |
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| Outline of Final Research Achievements |
Anti-inflammatory related proteins (Thioredoxin-like protein 1, Latexin) expression were incleased in exosomes derived human nerve cells on 4-methoxy amphetamine (4-MeO AP) abuse group compare to AP group. Moreover, phosphatidylcholines containing docosahexaenoic acids were reduced in exosomes derived human nerve cells on 4-MeO AP abuse group compare to AP group. In this study, we showed the difference inflammatory response induced by nerve cell-derived exosomes depends on the types of drugs.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では覚せい剤に類似した構造を持つ薬物が、Exosomeを介して脳内炎症応答を惹起するメカニズムの一端を明らかにした。世界のExosome研究において類似の結果報告はないことから、独自性の高い研究であるといえる。また、危険ドラッグの蔓延は社会問題であり、より強力な法整備を行う上での重要なエビデンスとなるものであり、社会的意義は非常に高い。
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Report
(4 results)
Research Products
(1 results)
