Regulatory mechanisms of zinc transporters and zinc signaling in breast cancer malignant progression
| Project/Area Number |
18K06676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳がん / 亜鉛 / 亜鉛トランスポーター / がん幹細胞様細胞 / PRDM14 / 低酸素 / HIF-1 / MTA-1 / 乳がん幹細胞 / 低酸素環境 / 悪性化進展 / ストレス応答性 |
|---|
| Outline of Final Research Achievements |
Breast cancer stem cell-like cells (BCSCs) lurk in very few populations within breast cancer tissues and can give rise to metastasis, recurrence, and drug resistance after a long period of time, contributing to poor clinical outcomes. We demonstrated that zinc is required to maintain BCSCs. Moreover, the mechanisms underlying the maintenance of BCSCs are regulated by zinc dependent PR domain zinc finger protein 14 (PRDM14) function through zinc transporters ZIP6 and ZIP7.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで謎に包まれていた乳がん幹細胞様細胞の維持機構において、亜鉛および亜鉛トランスポーターの関与を初めて明らかにし、本研究成果は、乳がん悪性化機構の本態解明に重要な方向性を示すものである。さらに、亜鉛ネットワークを利用した乳がん診断マーカーの開発や新たな乳がん治療方法の確立への道を切り開く突破口として、実用化に向けての貢献が期待される。
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Report
(5 results)
Research Products
(81 results)
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[Journal Article] Environmental pH stress influences cellular secretion and uptake of extracellular vesicles2021
Author(s)
Ikuhiko Nakase, Natsumi Ueno, Mie Matsuzawa, Kosuke Noguchi, Mami Hirano, Mika Omura, Tomoya Takenaka, Ayaka Sugiyama, Nahoko Bailey Kobayashi, Takuya Hashimoto, Tomoka Takatani-Nakase, Eiji Yuba, Ikuo Fujii, Shiroh Futaki, and Tetsuhiko Yoshida
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Journal Title
FEBS Open Bio
Volume: 11
Issue: 3
Pages: 753-767
DOI
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Peer Reviewed / Open Access
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[Presentation] 優秀発表賞受賞 シスチントランスポーターを利用した抗がん剤活性の制御とトリプルネガティブ乳がん治療の新戦略2021
Author(s)
松井千紘, 生嶌千菜美, 稲垣寧音, 緒方魅優, 後藤栞利, 赤沢真夢, 伊吹綾香, 大西杏奈, 野中愛子, 湯谷玲子, 崎谷愛未, 中瀬生彦, 中瀬朋夏
Organizer
第1回トランスポーター研究会関西部会
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[Presentation] Development of intracellular delivery system based on exosomes derived from cells in low pH cell culture condition2018
Author(s)
Natsumi Ueno, Mie Matsuzawa, Kosuke Noguchi, Tomoya Takenaka, Ayaka Sugiyama, Nahoko Bailey Kobayashi, Takuya Hashimoto, Tomoka Takatani-Nakase, Eiji Yuba, Ikuo Fujii, Shiroh Futaki, Tetsuhiko Yoshida, and Ikuhiko Nakase
Organizer
The 24th Peptide Forum in Kyoto, 2018: International Mini-Symposium on Peptide-Membrane Interaction and Intracellular Delivery
Related Report
Int'l Joint Research
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