Clinical and basic studies of biomarker for earlydetection of chronic kidney disease in salt-sensitive hypertension
Project/Area Number |
18K06768
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 47060:Clinical pharmacy-related
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Research Institution | Osaka University of Pharmaceutical Sciences |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
高井 真司 大阪医科大学, 医学研究科, 教授 (80288703)
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Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | バイオマーカ- / 食塩感受性高血圧 / 慢性腎臓病 / Dahl salt-sensitive rat / 臨床研究 / 非侵襲性 / 慢性腎臓病(CKD) / 尿細管障害 / バイオマーカー / 尿細管 / 食塩過剰摂取 / 高血圧 / 基礎研究 / 腎障害 / 食塩 / 腎線維化 |
Outline of Final Research Achievements |
In basic study, a high-salt intake to Dahl salt-sensitive (DS) caused elevated blood pressure, histological renal tubular damages, and increase in renak MDA and urinary vanin-1, both of which were suppressed by tempol and eplerenone. In clinical study, the group with eGFR < 60 mL/min per 1.73 m2 showed significantly higher levels of urinary vanin-1 than those with eGFR≧60 mL/min per 1.73 m2.The assessmentof urinary salt excretion by spot urine showed no significant difference between these two groups.
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Academic Significance and Societal Importance of the Research Achievements |
食塩感受性高血圧における尿細管障害の進展にROS活性を介したvanin-1の関与が明らかになった。一方、高血圧患者から採取された随時尿を用いた食塩排泄量推定値はCKDとの関連を認めなかったが、尿中vanin-1はCKDと関連することを明らかにした。本研究は新規バイオマーカーの萌芽研究として一定の意義を有するものと考える。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Risk Factors for Febrile Neutropenia Induced by Docetaxel Chemotherapy in Patients with Non-small Cell Lung Cancer2020
Author(s)
Uchida M, Yamaguchi Y, Hosomi S, Ikesue H, Mori Y, Maegawa N, Takano A, Sato Y, Hosohata K, Muroi N, Tomii K, Hashida T, Nakamura T.
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Journal Title
Biol Pharm Bull
Volume: 43
Pages: 1235-1240
DOI
Related Report
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[Journal Article] Risk factors for skin toxicities associated with bendamustine-based chemotherapy in patients with non-Hodgkin lymphoma.2020
Author(s)
Uchida M, Mori Y, Akiba K, Miyasaka M, Hirano T, Ikesue H, Yamaguchi Y, Takano A, Maegawa N, Shimomura Y, Hosohata K, Muroi N, Ishikawa T, Hashida T, Nakamura T.
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Journal Title
Biol Pharm Bull.
Volume: 43
Pages: 1577-1582
DOI
Related Report
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