Clinical database analysis for implementation of pharmacogenomics
Project/Area Number |
18K06782
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 47060:Clinical pharmacy-related
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
池田 義人 滋賀医科大学, 医学部, 客員助教 (40736980)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 個別医療 / 医療薬学 / 遺伝子多型 / ファーマコゲノミクス検査 / 臨床データベース / 有用性検証研究 |
Outline of Final Research Achievements |
Pharmacogenomics (PGx) test is expected to be a useful tool for realizing "Precision Medicine" in which optimal drug selection and dose adjustment are performed in accordance with individual patients. In the present study, a PGx database linked to an electronic medical record system operated in Shiga University of Medical Science hospitals was utilized to evaluate the relationship between PGx testing results and therapeutic effects in actual clinical practice. Genetic polymorphisms of a CYP2C19 which is drug-metabolizing enzyme of clopidogrel, an antiplatelet agent, were analyzed to obtain results suggesting the utility of PGx testing in clinical practice.
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果はファーマコゲノミクス検査に基づいた個々の患者に合わせた適切な薬剤選択・投与量決定を推進する為の基礎を担うものである。これらの成果をさらに発展させることにより、① 最適な治療効果を早急に得られることによる治療効率の向上、② 過剰投与防止に基づく有害事象発現率の低下による患者のQuality of Lifeの改善といった医学的なメリットに加え、③ 投与量の最適化による薬価負担の軽減や有害事象発現率の低減による医療費の軽減という薬剤経済学的なメリットも期待できることから、大きな社会的意義があると考えられる。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Comparison Between Clopidogrel and Prasugrel Associated With <i>CYP2C19</i> Genotypes in Patients Receiving Percutaneous Coronary Intervention in a Japanese Population2020
Author(s)
Yuichi Sawayama, Takashi Yamamoto, Yukinori Tomita, Kohei Asada, Noriaki Yagi, Megumi Fukuyama, Akashi Miyamoto, Hiroshi Sakai, Tomoya Ozawa, Tetsuichiro Isono, Daiki Hira, Tomohiro Terada, Minoru Horie, Yoshihisa Nakagawa
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Journal Title
Circulation Journal
Volume: 84
Issue: 9
Pages: 1575-1581
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2020-08-25
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exploratory Investigation of Target Pazopanib Concentration Range for Patients With Renal Cell Carcinoma2019
Author(s)
Satoshi Noda, Tetsuya Yoshida, Daiki Hira, Ryosuke Murai, Keiji Tomita, Teruhiko Tsuru, Susumu Kageyama, Akihiro Kawauchi, Yoshito Ikeda, Shin-ya Morita, Tomohiro Terada.
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Journal Title
Clinical Genitourinary Cancer
Volume: 17
Issue: 2
Pages: e306-e313
DOI
Related Report
Peer Reviewed
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[Journal Article] Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation.2018
Author(s)
Ueshima S, Hira D, Kimura Y, Fujii R, Tomitsuka C, Yamane T, Tabuchi Y, Ozawa T, Itoh H, Ohno S, Horie M, Terada T, Katsura T.
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Journal Title
Br. J. Clin. Pharmacol.
Volume: -
Issue: 6
Pages: 1301-1312
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 肝細胞がん患者におけるソラフェニブの血中濃度と治療効果・副作用の関連2020
Author(s)
野田哲史, 平大樹, 大﨑理英, 藤本剛英, 飯田洋也, 田中佐智子, 安藤朗, 谷眞至, 池田義人, 森田真也, 寺田智祐
Organizer
第41回日本臨床薬理学会学術総会
Related Report
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[Presentation] 薬物代謝酵素の遺伝子多型測定に基づくトラマドールの個別化投与設計2018
Author(s)
平 大樹, 岩下成人, 神谷貴樹, 中島 亮, 磯野哲一郎, 赤羽理也, 池田義人, 角本幹夫, 森田真也, 岡野友信, 今井晋二, 福井 聖, 寺 田智祐
Organizer
第40回 日本疼痛学会
Related Report