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Study on the mechanism of dry skin induction in arthritis model mice

Research Project

Project/Area Number 18K06802
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47060:Clinical pharmacy-related
Research InstitutionSuzuka University of Medical Science

Principal Investigator

Ooi Kazuya  鈴鹿医療科学大学, 薬学部, 教授 (40406369)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords乾燥皮膚 / 皮膚バリア機能 / マスト細胞 / コラーゲン / TSLP / 皮膚免疫 / 関節炎 / 非ステロイド性抗炎症薬 / 炎症
Outline of Final Research Achievements

In arthritic mice, mast cell proliferation was inhibited by the c-kit antibody, and the effect on dry skin was confirmed. In addition, the decrease in collagen in the skin and the increase in the number of mast cells were suppressed. Furthermore, factors such as TSLP, neutrophils, and active oxygen were involved. Next, we examined Th2 cells and Th17 cells that differentiated by stimulation of dendritic cells. Dry skin improved after Th2 and Th17 inhibitors. Arthritis mice treated with Th2 inhibitors had lower IL-6 and TNF-α than non-treated arthritic mice, and Th17 inhibitor administration reduced the number of mast cells in the skin. It was suggested that Th2 cells and Th17 cells induce dry skin expression by different mechanisms.

Academic Significance and Societal Importance of the Research Achievements

関節リウマチ患者において症例報告が散見される乾燥皮膚に着目した。関節炎においてマスト細胞が乾燥皮膚の誘導に関わる点については、すでに報告した消化器疾患モデルマウスでの現象と類似するが、TSLPやグルココルチコイド、樹状細胞などが関わる点については、関節炎特有の乾燥皮膚の誘導メカニズムであると考えられた。次に非ステロイド性抗炎症薬を関節炎マウスに投与することで、関節炎から誘導される乾燥皮膚が抑制されるかについて検討している。これらの知見も踏まえて、疾患によって乾燥皮膚の誘導メカニズムが異なる可能性が提示され、疾患ごとに適正な乾燥皮膚対策を講じることが可能な科学的根拠となるものと確信している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (6 results)

  • [Journal Article] Transepidermal Water Loss (TEWL)-decreasing Effect by Administration of Zinc in the Elderly People2020

    • Author(s)
      1.Masataka Deguchi , Hidehiko Jose , Keigo Nishida , Kazuya Ooi
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 140 Issue: 2 Pages: 313-318

    • DOI

      10.1248/yakushi.19-00198

    • NAID

      130007793399

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2020-02-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection of the Skin Barrier Function in Inflammatory Disease2019

    • Author(s)
      Kazuya Ooi
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 139 Issue: 12 Pages: 1553-1556

    • DOI

      10.1248/yakushi.19-00181-2

    • NAID

      130007754014

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2019-12-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis2019

    • Author(s)
      Goto K, Hiramoto K, Ooi K
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 3 Pages: 468-474

    • DOI

      10.1248/bpb.b18-00803

    • NAID

      130007606044

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-03-01
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of dry skin associating with type 2 diabetes mellitus using a KK-Ay/TaJcl mouse model.2018

    • Author(s)
      Sekijima H, Goto K, Hiramoto K, Komori R, Ooi K.
    • Journal Title

      Cutan Ocul Toxicol.

      Volume: 37 Issue: 4 Pages: 391-395

    • DOI

      10.1080/15569527.2018.1490746

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of reactive oxygen species and glucocorticoids on dry skin in a mouse model of Arthritis.2018

    • Author(s)
      Goto K, Hiramoto K, Kawakita M, Yamaoka M, Ooi K.
    • Journal Title

      Skin Pharmacol Physiol.

      Volume: 31 Issue: 4 Pages: 188-197

    • DOI

      10.1159/000488250

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of mast cells in the induction of dry skin in a mouse model of rheumatoid arthritis.2018

    • Author(s)
      Goto K, Hiramoto K, Kita H, Ooi K.
    • Journal Title

      Cutan Ocul Toxicol.

      Volume: 37 Issue: 1 Pages: 61-70

    • DOI

      10.1080/15569527.2017.1337784

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] デキストラン硫酸ナトリウム誘導性潰瘍性大腸炎モデルマウスに対する高用量ビタミンC投与による改善効果2020

    • Author(s)
      五藤健児, 平本恵一, 大井一弥
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 血液透析患者の掻痒と血中微量元素の関連2019

    • Author(s)
      出口昌孝, 平岡純, 西田圭吾, 安井裕之, 町田博文, 大井一弥
    • Organizer
      第63回日本薬学会関東支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 関節炎モデルマウスにおける乾燥皮膚発現に対するグルココルチコイドの影響2019

    • Author(s)
      五藤健児, 平本恵一, 高田偉隠, 大井一弥
    • Organizer
      第63回日本薬学会関東支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 好中球が関節炎モデルマウスにおける乾燥皮膚の発現に及ぼす影響2019

    • Author(s)
      五藤健児、平本恵一、大井一弥
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 関節炎における乾燥皮膚には樹状細胞が関与する2018

    • Author(s)
      五藤健児、平本恵一、大井一弥
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 関節炎モデルマウスの乾燥皮膚誘導における活性酸素の役割2018

    • Author(s)
      五藤健児、平本恵一、山岡実由、大井一弥
    • Organizer
      第64回日本薬学会東海支部大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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