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Study of the mechanism of polynuclear formation and its regulatory mechanism in self-beating myocardial progenitor cells ACMs

Research Project

Project/Area Number 18K06871
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 48020:Physiology-related
Research InstitutionShiga University of Medical Science

Principal Investigator

Omatsu-Kanbe Mariko  滋賀医科大学, 医学部, 准教授 (80161397)

Co-Investigator(Kenkyū-buntansha) 森 雅樹  滋賀医科大学, 神経難病研究センター, 客員准教授 (10602625)
星野 真介  滋賀医科大学, 医学部, 助教 (70747576)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心筋細胞 / ACMs / 心筋前駆細胞 / 多核 / 細胞融合 / 虚血耐性 / 核形成異常 / DNAブリッジ / 核分裂 / DNA ブリッジ / 核形異常 / 非定型心筋細胞 / 多核形成 / 核膜 / 細胞増殖
Outline of Final Research Achievements

The adult mammalian heart contains several kinds of cardiac stem or progenitor cells. Atypically-shaped cardiomyocytes (ACMs) are derived from mouse heart that spontaneously develop into beating cells. We found that the ACMs can fuse with each other to become multinucleate large beating cells.

Academic Significance and Societal Importance of the Research Achievements

心筋細胞は低酸素や機械的刺激、酸性化に感受性が高く、損傷した組織の再生は不可能である。しかし、心臓組織中に低酸素等への耐性の高いACMsが生存していることは、何らかの生理的意義をもつ考えられ、将来の再生技術への手がかりとなる可能性がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Journal Article] Expression and functional maintenance of volume-regulated anion channels in myometrial smooth muscles of pregnant mice2022

    • Author(s)
      Yamada, W.G.Ding, M. Omatsu-Kanbe, F. Toyoda, S. Tsuji, D. Katsura, F. Kimura, H. Matsuura, T. Murakami.
    • Journal Title

      Experimental Animals

      Volume: 71 Issue: 2 Pages: 123-130

    • DOI

      10.1538/expanim.21-0111

    • NAID

      130008116959

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Antegrade Perfusion Method for Cardiomyocyte Isolation from Mice.2021

    • Author(s)
      M. Omatsu-Kanbe, R. Fukunaga, X. Mi and H. Matsuura
    • Journal Title

      J Vis Exp

      Volume: 171 Issue: 171

    • DOI

      10.3791/61866

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevation of propofol sensitivity of cardiac IKs channel by KCNE1 polymorphism D85N.2021

    • Author(s)
      A. Kojima, X. Mi, Y. Fukushima, W. G. Ding, M. Omatsu-Kanbe and H. Matsuura
    • Journal Title

      Br J Pharmacol

      Volume: 178 Issue: 13 Pages: 2691-2708

    • DOI

      10.1111/bph.15460

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective activation of adrenoceptors potentiates IKs current in pulmonary vein cardiomyocytes through the protein kinase A and C signaling pathways2021

    • Author(s)
      X. Mi, W. G. Ding, F. Toyoda, A. Kojima, M. Omatsu-Kanbe and H. Matsuura
    • Journal Title

      J Mol Cell Cardiol

      Volume: 161 Pages: 86-97

    • DOI

      10.1016/j.yjmcc.2021.08.004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization and functional role of rapid- and slow-activating delayed rectifier K + currents in atrioventricular node cells of guinea pigs.2021

    • Author(s)
      Yuasa, A. Kojima, X Mi, W.G, Ding, M. Omatsu-Kanbe, H. Kitagawa, H. Matsuura.
    • Journal Title

      Pflugers Arch.

      Volume: 473 Issue: 12 Pages: 1885-1898

    • DOI

      10.1007/s00424-021-02617-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Antegrade Perfusion Method for Cardiomyocyte Isolation from mice2021

    • Author(s)
      Omatsu-Kanbe M, Fukunaga R, Mi X, Matsuura H.
    • Journal Title

      Journal of Visualized Experiments, in press

      Volume: 000 Pages: 000-000

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevation of propofol sensitivity of cardiac <i>I</i><sub>Ks</sub> channel by KCNE1 polymorphism D85N2021

    • Author(s)
      Kojima A, Xinya M, Fukushima Y, Ding W-G, Omatsu-Kanbe M, Matsuura H.
    • Journal Title

      British Journal of Pharmacology, in press

      Volume: 000 Pages: 000-000

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A simple antegrade perfusion method for isolating viable single cardiomyocytes from neonatal to aged mice2018

    • Author(s)
      Omatsu-Kanbe Mariko、Yoshioka Kengo、Fukunaga Ryo、Sagawa Hironori、Matsuura Hiroshi
    • Journal Title

      Physiological Reports

      Volume: 6 Issue: 9 Pages: e13688-e13688

    • DOI

      10.14814/phy2.13688

    • NAID

      120006539729

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Nuclear heterogeneity in multinucleated ventricular myocytes in mice.2021

    • Author(s)
      Mi, X., Fukunaga, R., Ding, W.-G., Matsuura, H., Omatsu-Kanbe, M.
    • Organizer
      第126回日本解剖学会総会・全国学術集会 第98回日本生理学会大会 合同大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Physiological role and the three-dimensional localization of cardiac progenitor cells in the mouse heart2021

    • Author(s)
      尾松万里子、福永 諒、下田 翔、揚妻正和、鍋倉淳一、西田基宏、松浦 博
    • Organizer
      第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Cell fusion and irregular nuclear division in multinuclear cardiac progenitor cells2021

    • Author(s)
      福永 諒,尾松万里子,松浦 博
    • Organizer
      第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Nuclear heterogeneity in multinucleated ventricular myocytes in mice2021

    • Author(s)
      糜 心雅,福永 諒,丁 維光,松浦 博,尾松万里子
    • Organizer
      第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Property and possible role of cardiac progenitors atypically-shaped cardiomyocytes2020

    • Author(s)
      Omatsu-Kanbe M, Fukunaga R, Shimoda K, Agetsuma M, Nabekura J, Nishida M, MatsuuraH.
    • Organizer
      生理研心血管国際集会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Presence of ANP promotor-driven AcGFP-expressing cardiac progenitor cells in mice heart2020

    • Author(s)
      Fukunaga R, Shimoda K, Agetsuma M, Nabekura J, Nishida M, MatsuuraH, Omatsu-Kanbe M.
    • Organizer
      生理研心血管国際集会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional role of delayed rectifier K+ current in the spontaneous automaticity of the guinea-pig2020

    • Author(s)
      Mi X, Ding W-G, Kojima A, Omatsu-Kanbe M, Matsuura H.
    • Organizer
      生理研心血管国際集会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multinucleation of cardiac progenitor cells by cell fusion and nuclear division.2020

    • Author(s)
      Omatsu-Kanbe, M., Fukunaga, R., Matsuura, H.
    • Organizer
      J. Physiol. Sci. 70: S86. (第97回日本生理学会大会)
    • Related Report
      2019 Research-status Report
  • [Presentation] Identification of ANP-marked cardiac progenitor cells in mouse heart that develop into beating cells.2019

    • Author(s)
      Omatsu-Kanbe, M., Fukunaga, R., Shimoda, K., Agetsuma, M., Nabekura, J., Nishida, M., Matsuura, H.
    • Organizer
      The 50th NIPS International Symposium ‘MIRACLES’ in Cardiovascular Physiology - Metabolism, Interaction, Regulation, Application, Chemical Biology, Longevity, Exercise and Signaling -
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Irregular division of the nucleus without cytokinesis in cardiac progenitor cells of mouse heart2019

    • Author(s)
      Fukunaga R. Omatsu-Kanbe, M. Matsuura, H.
    • Organizer
      9th FAOPS Congress 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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