| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
5-Aminolevulinic acid (ALA) is one of essential biomolecules for cellular energy production in mitochondria, and is biosynthesized by ALA synthase. The activity of the enzyme decreases as aging, and our studies by mouse models suggested that the decreased activity for producing ALA with aging is relevant to sarcopenia and diabetes caused by aging and supplementation of ALA can recover those aging-related abnormalities. Further studies showed that the diabetes caused by aging can be attributed to dysregulation of storage of glucose in muscle and the liver and of insulin secretion from the pancreas. These studies imply supplemental ALA can extend healthy life expectancy.
|
