Analysis of mTORC1-FOXK1 axis in lifestyle-related diseases
| Project/Area Number |
18K06962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49010:Pathological biochemistry-related
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| Research Institution | Nagoya City University |
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Principal Investigator |
NAKATSUMI Hirokazu 名古屋市立大学, 医薬学総合研究院(薬学), 講師 (20596837)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | mTORC1 / 脂肪肝 / 糖尿病 / 生活習慣病 / 肝疾患 / 慢性炎症 / FOXK1 |
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| Outline of Final Research Achievements |
There are two similarities between lifestyle-related diseases and cancer. The first point is that they are in a chronic inflammatory state, and the second point is that abnormal activation of mTORC1 is observed. Based on these similarities, we hypothesized that the transcription factor FOXK1, which is activated downstream of mTORC1, promotes both of lifestyle-related diseases and cancer. We identified that FOXK1 deficient mice were improved fatty liver-related inflammation, fibrosis, and tumorigenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
生活習慣病、特に非アルコール性脂肪性肝炎の患者数は増加傾向にあり、アルコール性・ウイルス性肝炎が減少傾向にあることと対照的である。治療法の確立は急務であるが、現在は減量を基本とした治療法以外は存在しない。本研究では、非アルコール性脂肪性肝炎の新たな治療ターゲットとしてFOXK1を見出した。FOXK1を標的とした薬剤の開発は脂肪肝と関連する炎症、線維症、および腫瘍形成を抑制する可能性がある。
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.2020
Author(s)
Yamauchi, Y., Nita, A., Nishiyama, M., Muto, Y., Shimizu, H., Nakatsumi, H., Nakayama, K. I.
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Journal Title
Genes to Cells
Volume: XX
Pages: 427-438
DOI
Related Report
Peer Reviewed
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[Journal Article] Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation2020
Author(s)
Shirane M, Wada M, Morita K, Hayashi N, Kunimatsu R, Matsumoto Y, Matsuzaki F, Nakatsumi H, Ohta K, Tamura Y, and Nakayama KI
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Journal Title
Nat. Commun.
Volume: 11
Pages: 4576-4576
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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