Pathological features define human cancer physiology and elucdation of it's biological mechanism
Project/Area Number |
18K07035
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 49020:Human pathology-related
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Research Institution | National Cancer Center Japan |
Principal Investigator |
Kojima Motohiro 国立研究開発法人国立がん研究センター, 臨床開発センター, ユニット長 (30338470)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | がん / がん微小環境 / 癌 / 腫瘍微小環境 / 物性 / 癌微小環境 / メカノトランスダクション / 癌関連線維芽細胞 / Transgelin / 大腸癌 / transgelin / 硬さ / 線維芽細胞 |
Outline of Final Research Achievements |
We performed immunohistochemical analysis of Transgelin and α-SMA in 96 samples from surgically resected colorectal cancer patients underwent colectomy from February to December in 2012. Transgelin expression in cancer tissue was detected predominantly in cancer associated fibroblast, and co-expression of Transgelin and α-SMA were found in cancer stroma. On the other hand, Transgelin expression in cancer cells was faint. Transgelin expression also associated tumor elasticity and was found to be a prognostic factor. Based on these results, we finished to created knock-down constract of Transgelin.
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Academic Significance and Societal Importance of the Research Achievements |
腫瘍物性が腫瘍の悪性度、治療抵抗性に関わる事が報告されているが腫瘍組織は、がん細胞のみならず、血管、炎症細胞、線維芽細胞など多彩な細胞種から構成され、腫瘍物性を規定する細胞種や生物学的機構が分かっていない。また、生体の物性を計測する方法が少なく、臨床的有用性の報告が少ないため、ヒト腫瘍組織の物性を計測する標準的な手法が確立していない。本研究で我々が行ったヒト組織を使用した腫瘍物性の研究は、機器開発基盤情報となる腫瘍物性計測の有用性を示し、創薬開発基盤となる腫瘍物性構築における分子機構に Transgelinが関与するかを検討する環境が整備された。
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Guidance for diagnosing autoimmune pancreatitis with biopsy tissues2020
Author(s)
Notohara K, Kamisawa T, Fukushima N, Furukawa T, Tajiri T, Yamaguchi H, Aishima S, Fukumura Y, Hirabayashi K, Iwasaki E, Kanno A, Kasashima S, Kawashima A, Kojima M, Kubota K, Kuraishi Y, Mitsuhashi T, Naito Y, Naitoh I, Nakase H, Nishino T, Ohike N, Sakagami J, Shimizu K, Shiokawa M, Uehara T, et al.
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Journal Title
Pathol Int
Volume: 70
Issue: 10
Pages: 699-711
DOI
Related Report
Peer Reviewed
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[Journal Article] Survival Outcomes of Resected BRAF V600E Mutant Colorectal Liver Metastases: A Multicenter Retrospective Cohort Study in Japan2020
Author(s)
Kobayashi S, Takahashi S, Takahashi N, Masuishi T, Shoji H, Shinozaki E, Yamaguchi T, Kojima M, Gotohda N, Nomura S, Yoshino T, Taniguchi H.
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Journal Title
Ann Surg Oncol.
Volume: 27(9)
Issue: 9
Pages: 3307-3315
DOI
Related Report
Peer Reviewed
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[Journal Article] The potential application of PD-1 blockade therapy for early-stage biliary tract cancer.2020
Author(s)
Umemoto K, Togashi Y, Arai Y, Nakamura H, Takahashi S, Tanegashima T, Kato M, Nishikawa T, Sugiyama D, Kojima M, Gotohda N, Kuwata T, Ikeda M, Shibata T, Nishikawa H.
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Journal Title
Int Immunol.
Volume: 32
Issue: 4
Pages: 273-281
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ki67 expression and localization of T cells after neoadjuvant therapies as reliable predictive markers in rectal cancer.2020
Author(s)
Imaizumi K, Suzuki T, Kojima M, Shimomura M, Sakuyama N, Tsukada Y, Sasaki T, Nishizawa Y, Taketomi A, Ito M, Nakatsura T.
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Journal Title
Cancer Sci.
Volume: 111
Issue: 1
Pages: 23-35
DOI
Related Report
Peer Reviewed
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[Journal Article] Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung.2019
Author(s)
Oki T, Aokage K, Ueda T, Sugano M, Tane K, Miyoshi T, Kojima M, Fujii S, Kuwata T, Ochiai A, Funai K, Tsuboi M, Ishii G.
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Journal Title
Pathol Int.
Volume: 69
Issue: 9
Pages: 526-535
DOI
Related Report
Peer Reviewed
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[Journal Article] Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment.2019
Author(s)
Martin JD, Panagi M, Wang C, Khan TT, Martin MR, Voutouri C, Toh K, Papageorgis P, Mpekris F, Polydorou C, Ishii G, Takahashi S, Gotohda N, Suzuki T, Wilhelm ME, Melo VA, Quader S, Norimatsu J, Lanning RM, Kojima M, Stuber MD, Stylianopoulos T, Kataoka K, Cabral H.
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Journal Title
ACS Nano.
Volume: 13
Issue: 6
Pages: 6396-6408
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on2019
Author(s)
Omori T, Aokage K, Nakamura H, Katsumata S, Miyoshi T, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Ikeda N, Tsuboi M, Ishii G.
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Journal Title
J Cancer Res Clin
Volume: 145
Issue: 7
Pages: 1773-1783
DOI
Related Report
Peer Reviewed
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[Journal Article] Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma.2018
Author(s)
Sakai T, Aokage K, Neri S, Nakamura H, Nomura S, Tane K, Miyoshi T, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Iyoda A, Tsuboi M, Ishii G.
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Journal Title
Lung Cancer
Volume: 126
Pages: 64-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification.2018
Author(s)
Takahashi D, Kojima M, Suzuki T, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Gotohda N, Ikeda M, Nakatsura T, Ochiai A, Nagino M.
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 13166-13166
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Steroidogenesis in ovarian-like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms2018
Author(s)
Kumata H, Murakami K, Ishida K, Miyagi S, Arakawa A, Inayama Y, Kinowaki K, Ochiai A, Kojima K, Higashi M, Moritani S, Kuwahara K, Nakatani Y, Kajiura D, Tamura G, Kijima H, Yamakawa M, Shiraishi T, Inadome Y, Murakami K, Suzuki H, Sawai T, Unno M, Kamei T, Sasano H
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Journal Title
Hepatol Res
Volume: 48
Issue: 12
Pages: 989-999
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion2018
Author(s)
Hashimoto T, Tanaka Y, Ogawa R, Mori T, Yoshida H, Taniguchi H, Hiraoka N, Kojima M, Oono Y, Saito Y, Sekine S
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Journal Title
Mod Pathol
Volume: 31
Issue: 10
Pages: 1588-98
DOI
Related Report
Peer Reviewed
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[Presentation] More Objective Assessment of Tumor Regression in Post Neoadjuvant Therapy Resections for Pancreatic Ductal Adenocarcinoma:A Multicenter Study on Comparison of Multiple Tumor Regression Grading Systems2019
Author(s)
Matsuda Y, Ohkubo S, Fukumura Y, Hirabayashi K, Yamaguchi H, Sahara Y, Kawanishi A, Takahashi S, Arai T, Kojima M, Mino-Kenudson M
Organizer
American pancreas association meeting
Related Report
Int'l Joint Research
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[Presentation] 4.Multiple cancer risk in rectal neuroendocrine tumors,and it's association with PHLDA3-LOH.2019
Author(s)
Kojima M, Chen Y, Ikeda K, Tsukada Y, Takahashi D, Kawano S, Amemiya K, Ito M, Ohki R, Ochiai A
Organizer
USCAP 2019
Related Report
Int'l Joint Research
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